113 results match your criteria: "Chongqing University FuLing Hospital[Affiliation]"
MR Imaging of Typical Ovarian Hemangioma: A Case Report.
Curr Med Imaging
August 2024
Department of Medical Imaging, Chongqing University Fuling Hospital, Chongqing, China.
Article Synopsis
- Ovarian hemangioma is a rare tumor, with about 60 cases reported, but only around 10 investigated using MRI and ultrasound, often found by chance during autopsies or surgeries.
- A case study details a 51-year-old woman with an asymptomatic ovarian hemangioma, discovered through a raised CA125 level and MRI, which showed a cystic solid mass in the left ovary.
- The conclusion highlights that the MRI features of ovarian hemangiomas resemble those of liver hemangiomas, underlining the need for awareness of these radiological traits for better diagnosis and treatment.
Pelvic organ-preserving radical cystectomy versus standard radical cystectomy in female patients diagnosed with bladder cancer.
World J Surg Oncol
August 2024
Department of Urology, Chongqing University Fuling Hospital, No.2 Gaosuntang Road, Fuling District, Chongqing, 408000, China.
Article Synopsis
- Pelvic organ-preserving radical cystectomy (POPRC) offers better quality of life post-surgery for women with bladder cancer compared to standard radical cystectomy (SRC), but concerns remain about its effectiveness in survival outcomes.
- A study involving 2,193 female bladder cancer patients showed that while initially POPRC had similar overall survival (OS) rates as SRC, it was linked to significantly worse OS after accounting for patient differences.
- Subgroup analyses indicated that while patients with non-muscle invasive bladder cancer (NMIBC) and T2 tumors had similar OS rates with POPRC, those with T3 tumors had poorer outcomes, highlighting a need for stricter screening criteria for POPRC candidates.
Antivenom treatment for snakebite envenoming.
Nat Rev Dis Primers
August 2024
Emergency Department, Chongqing University Fuling Hospital, School of Medicine, Chongqing University, Chongqing, China.
Development and Validation of an Inflammation-Combined Prognostic Index (ICPI)-Based Nomogram for Predicting Overall Survival in Gastric Cancer.
J Inflamm Res
August 2024
Department of General Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Article Synopsis
- The study investigates a new inflammatory marker called the inflammation-combined prognostic index (ICPI) that includes NLR, PLR, and MLR, to see how it relates to gastric cancer (GC) prognosis and survival.
- Data from 876 GC patients were analyzed using various statistical methods, including regression analyses, to establish the significance of ICPI and other factors in determining overall survival (OS).
- The results showed that higher levels of ICPI and related ratios were linked to worse outcomes, leading to the development of an accurate nomogram for predicting OS tailored for GC patients.
Catalytic asymmetric functionalization and dearomatization of thiophenes.
Chem Sci
August 2024
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University Chongqing 401331 P. R. China
Article Synopsis
- * It utilizes vinylidene-quinone methide (VQM) as an intermediate to achieve this synthesis.
- * The study successfully produces axially chiral naphthyl-benzothiophene derivatives and chiral spiranes with high yields and excellent enantioselectivities.
The mechanism of Taohong Siwu decoction in treating chemotherapy-induced peripheral neuropathy: a network pharmacology and molecular docking study.
Transl Cancer Res
July 2024
Division of Hematology, The Comprehensive Cancer Center, Chongqing University Fuling Hospital, Chongqing, China.
Article Synopsis
- Taohong Siwu Decoction (THSWD) is a traditional Chinese medicine known for improving blood circulation and energy, with potential effectiveness against chemotherapy-induced peripheral neuropathy (CIPN) caused by paclitaxel.
- The study utilized network pharmacology and molecular docking to explore how THSWD interacts with targets related to CIPN, identifying 105 common targets and implicating several key signaling pathways.
- Findings suggest that THSWD has considerable therapeutic potential for CIPN, supported by strong binding activity between its active components and target proteins.
Catalytic asymmetric construction of bridged bicyclo[.3.1] rings using an intramolecular Diels-Alder reaction.
Chem Commun (Camb)
August 2024
Chongqing University FuLing Hospital, Chongqing University, Chongqing 408000, P. R. China.
Article Synopsis
- The study introduces a unique enantioselective intramolecular Diels-Alder (IMDA) reaction using a specific compound called vinyl branched vinylidene-quinone methide (VQM).
- This reaction is notable for its ability to control site selectivity, resulting in the formation of chiral bridged bicyclic structures.
- The yields of these products are impressive, reaching as high as 85%, with enantioselectivities reported at an exceptional 97% ee.
A comprehensive prediction model predicts perihematomal edema growth in the acute stage after intracerebral hemorrhage.
Clin Neurol Neurosurg
October 2024
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:
Article Synopsis
- * Researchers analyzed data from 226 patients who received a CT scan within 6 hours of their symptoms and used various measurements (hematoma volume, PHE volume, and platelet-to-lymphocyte ratio) to identify predictors of PHE growth.
- * The findings revealed that a PHE volume increase of 5.5 mL is a critical threshold for predicting poor outcomes, with significant predictors being hematoma surface area, presence of an expansion-prone hematoma, and PLR,
Argonaute-2 autoantibodies: a promising biomarker for predicting mortality in HBV-related acute-on-chronic liver failure patients with cirrhosis.
Front Cell Infect Microbiol
August 2024
Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Article Synopsis
- This research studies how a virus called HBV can cause the body to make harmful antibodies that affect the liver.
- The scientists looked at blood samples from people with liver problems to find specific antibodies that can help predict how sick someone might get.
- They found that a particular antibody, called AGO2-Abs, can help predict if a patient with liver issues might not survive, and it showed it was linked to worsening liver damage.
Increased SARS-CoV-2 reinfection frequency, attenuated severity, and risk factor analysis in patients with hematological malignancies.
J Infect
September 2024
Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China. Electronic address:
Three-dimensional deep learning model complements existing models for preoperative disease-free survival prediction in localized clear cell renal cell carcinoma: a multicenter retrospective cohort study.
Int J Surg
November 2024
Department of Urology, The First Affiliated Hospital of Chongqing Medical University.
Article Synopsis
- * Utilizing CT images, the researchers created a ResNet 50 model that generated a DL computed risk score (DLCR) which successfully stratified patients by risk levels and outperformed other predictive models, including the Rad-Score and traditional clinical models.
- * With data from 707 patients, the DLCR demonstrated effective risk assessment across various subgroups and identified patients at higher risk of recurrence, highlighting its potential for improving clinical decision-making prior to surgery.
Article Synopsis
- Proximal gastrectomy (PG) is a surgery for proximal gastric cancer (PGC) that aims to preserve stomach function; this study compares its long-term results against total gastrectomy (TG).
- Researchers analyzed data from the SEER database, comparing overall survival (OS) and cancer-specific survival (CSS) between PG and TG patients, using propensity score matching to reduce bias.
- Findings showed that before matching, PG had better outcomes, but after adjusting for variables, both PG and TG had similar long-term survival results, indicating PG is a safe option for treating PGC.
Deep learning system for malignancy risk prediction in cystic renal lesions: a multicenter study.
Insights Imaging
May 2024
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Article Synopsis
- An interactive, non-invasive AI system was developed to predict the malignancy risk associated with cystic renal lesions (CRLs) by utilizing a combination of 3D segmentation and classification models.
- The study analyzed data from 715 patients and used advanced techniques like a 3D-ResNet50 network and gated recurrent unit (GRU) for feature extraction and classification.
- Results showed outstanding performance in distinguishing benign from malignant CRLs, achieving high accuracy and sensitivity, thus enhancing clinical decision-making in diagnosing these lesions.
Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets.
Expert Opin Drug Discov
June 2024
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Article Synopsis
- * The authors analyze how DEL can address the challenges faced in FBDD, focusing on its ability to enhance hit discovery, especially for complex therapeutic targets with difficult drug-target interfaces.
- * The review emphasizes that future advancements in DEL technology and its broader applications could significantly enhance fragment-based drug discovery, particularly by increasing chemical diversity and targeting tough biological challenges.
Endobronchial ultrasound-guided cautery-assisted transbronchial mediastinal cryobiopsy in the diagnosis of fibrosing mediastinitis secondary to atypical sarcoidosis: a case report.
AME Case Rep
March 2024
Department of Respiratory and Critical Care Medicine, Chongqing University Fuling Hospital, Chongqing, China.
Article Synopsis
- Fibrosing mediastinitis (FM) linked to atypical sarcoidosis is rarely reported and has nonspecific symptoms, making diagnosis challenging, as seen in a case with multiple pulmonary nodules and pleural effusions.
- A 70-year-old man's persistent cough and dyspnea led to a diagnosis of atypical sarcoidosis secondary FM through advanced imaging and biopsy techniques, resulting in significant improvement after glucocorticoid treatment.
- The study highlights the importance of recognizing specific imaging patterns for diagnosing FM and suggests that endobronchial ultrasound-guided biopsy is an effective method for obtaining necessary tissue samples for accurate diagnosis.
Comparison of Prone With Lithotomy Position in Removal of Posterior Myoma in Transvaginal Natural Orifice Endoscopic Surgery: A Prospective Cohort Study.
J Minim Invasive Gynecol
September 2024
Chengdu Women's and Children's Central Hospital, School of Medicine (X. Li, Liu, Hou, Zeng, Xiong, Yang, Lin, and He), University of Electronic Science and Technology of China, Chengdu, China. Electronic address:
Article Synopsis
- Vaginal natural orifice transluminal endoscopic surgery (vNOTES) offers benefits such as no visible scars and quicker recovery times, but removing posterior myomas can be challenging in the traditional lithotomy position.
- This study compares outcomes for patients undergoing myomectomy in either the prone or lithotomy position, with the finding that the prone position significantly reduces operation time without raising complication rates.
- Results showed that most patients (64.2%) were assessed in the prone position, which allowed for more efficient surgeries and a lower rate of surgical conversion, suggesting the need for careful preoperative evaluations and potential for timely interventions.
Risk factors of sleep-disordered breathing and poor asthma control in children with asthma.
BMC Pediatr
April 2024
The Children's Hospital of Chongqing Medical University, 136 Zhongshan Second Road, Yuzhong District, Chongqing, 400014, China.
Article Synopsis
- Sleep-disordered breathing (SDB) significantly affects asthma control among children, with a prevalence of 21.6% observed in a study of 397 children.
- Various factors contribute to SDB in asthmatic children, including allergic rhinitis, chronic tonsillitis, gastroesophageal reflux, adenoid hypertrophy, recurrent respiratory infections, and a family history of snoring.
- Additionally, SDB and irregular medication use are linked to poorer asthma management, with 19.6% of participants experiencing inadequate control of their asthma symptoms.
Diagnostic and Predictive Efficacy of Synovial Fluid Versus Serum C-Reactive Protein Levels for Periprosthetic Joint Infection and Reimplantation Success.
J Arthroplasty
August 2024
Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- The study investigates the effectiveness of synovial fluid C-reactive protein (syCRP) versus serum C-reactive protein (seCRP) in diagnosing periprosthetic joint infection (PJI) and predicting reimplantation success in patients.
- Results show that syCRP levels are significantly higher in PJI patients compared to those undergoing aseptic revision, and syCRP demonstrates greater diagnostic accuracy with an area under the curve (AUC) of 0.93 compared to 0.80 for seCRP.
- The findings suggest that syCRP is a more reliable marker than seCRP for assessing infection status and determining the timing for reimplantation in patients with PJI.
Quantitative imaging for predicting hematoma expansion in intracerebral hemorrhage: A multimodel comparison.
J Stroke Cerebrovasc Dis
July 2024
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:
Background: Several studies report that radiomics provides additional information for predicting hematoma expansion in intracerebral hemorrhage (ICH). However, the comparison of diagnostic performance of radiomics for predicting revised hematoma expansion (RHE) remains unclear.
Methods: The cohort comprised 312 consecutive patients with ICH.
NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN-γ released.
Biomaterials
July 2024
Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China. Electronic address:
Metallic biomaterials activate tumor ferroptosis by increasing oxidative stress, but their efficacy is severely limited in tumor microenvironment. Although interferon gamma (IFN-γ) can promote tumor ferroptosis sensitivity by inhibiting the antioxidant system and promoting lipid accumulation, this effect limited by the lack of IFN-γ accumulation in tumors. Herein, we report a near-infrared (NIR)-responsive HCuS nanocomposite (HCuS-PE@TSL-tlyp-1) that can stimulate immunogenic cell death (ICD)-mediated IFN-γ secretion through exogenous oxidative stress, thereby achieving cascaded ferrotherapy by mutually reinforcing ferroptosis and systemic immunity.
View Article and Find Full Text PDFSema3A Inhibits Osteolytic Bone Metastasis of Non-small Cell Lung Cancer.
Recent Pat Anticancer Drug Discov
April 2024
Department of Oncology, Chongqing University Fuling Hospital, No. 2, Gaosuntang Road, Fuling District, Chongqing, 408000, China.
Background: Osteolytic bone metastasis is a common complication of Non-Small Cell Lung Cancer (NSCLC), resulting in bone pain, hypercalcemia, and fractures that severely reduce the quality of life and survival time of patients. Semaphorins 3A (Sema3A) is one of the isoforms of the Semaphorins family, which is important in a variety of physiological and pathological processes, such as angiogenesis, immune regulation, and tumorigenesis. However, the role of Sema3A in the development of osteolytic bone metastasis in NSCLC is unknown.
View Article and Find Full Text PDFLabel-Free, Sensitive, and Versatile Colorimetric Method for Molecule Detection via the G-Quadruplex-Based Signal Quenching Strategy.
ACS Omega
April 2024
Central Laboratory, Chongqing University FuLing Hospital, Chongqing 408099, China.
Signal amplification strategies have emerged as a prominent tool in the field of improving the detection sensitivity of small extracellular vesicles (sEVs). It is important to highlight that the utilization of signal quenching strategies is not commonly implemented. A detection technique for sEVs was established based on the unwinding of G-quadruplex using Klenow fragment polymerase (KF), which served as an inspiration for this study.
View Article and Find Full Text PDFPrognostic value and potential function of a novel heme-related LncRNAs signature in gastric cancer.
Cell Signal
June 2024
Department of General Surgery, Chongqing University Fuling Hospital, 408000 Chongqing, China. Electronic address:
Heme is a coordination complex formed by the binding of iron ions and porphyrin rings. Its metabolic processes are associated with various cancers, including gastric cancer (GC). In recent years, long non-coding RNAs (LncRNAs) have been identified as key regulatory factors in GC.
View Article and Find Full Text PDFSnakebite envenomation: first aid and rescue network.
Lancet
March 2024
Emergency Department, Chongqing University Fuling Hospital, School of Medicine, Chongqing University, Chongqing 408000, China. Electronic address:
Effect of esketamine on the EC50 of remifentanil for blunting cardiovascular responses to endotracheal intubation in female patients under general anesthesia: a sequential allocation dose-finding study.
BMC Anesthesiol
February 2024
Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Article Synopsis
- This study evaluated how esketamine affects the relationship between remifentanil dosage and cardiovascular responses during endotracheal intubation under general anesthesia with propofol.
- Patients aged 18-65 were divided into two groups: one received esketamine before anesthesia, while the other received saline.
- Results showed that esketamine significantly lowered the effective concentration (EC) of remifentanil needed to manage cardiovascular responses during intubation compared to the control group.