Technical advances in laboratory diagnosis of bloodstream infections.

Introduction: Rapid and accurate laboratory diagnosis is essential for the effective treatment of bloodstream infection (BSI).

Areas Covered: This review aims to address novel and traditional approaches that exhibit different performance characteristics in the diagnosis of BSI. In particular, the authors will discuss the pros and cons of the blood culture-based phenotypic methods, nucleic acid-targeted molecular methods, and host response-targeted biomarker detection in the diagnosis of BSI.

Biomimetic Air-Lifted Organ Culture System with a Protective Coverage Membrane for Full-Thickness Corneal Preservation.

Effective storage and utilization of limited donor corneal resources are in high demand to alleviate the shortage of donor corneal tissue. Here, we designed a static air-lifted organ culture system equipped with a protective coverage membrane, namely, an air-lifted OC-P system, to provide a biomimetic physiological environment for full-thickness corneal preservation. The air-lifted OC-P system features a unique collagen-based protective coverage membrane that can offer a moist, oxygen-rich environment for corneal epithelium, produce an appropriate intraocular pressure onto the cornea by gravity, and facilitate the maintenance of the organ culture medium level for nutrient supply during corneal preservation.

A Novel HTNV Budding Inhibitor Interferes the Interaction Between Viral Glycoprotein and Host ESCRT Accessory Protein ALIX.

Virus budding is a critical step in the replication cycle of enveloped viruses, closely linked to viral spread, disease progression, and clinical outcomes. The budding of many enveloped RNA viruses is facilitated by the hijacking of the host endosomal sorting complex required for transport (ESCRT) proteins through viral late domains. These late domains are essential for progeny virus production and are highly conserved, making the interaction between late domains and host ESCRT proteins a potential target for the development of antiviral therapeutics.

Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study.

Background: There is a well-established relationship between liver conditions and cardiovascular diseases. However, uncertainty persists regarding the contribution of liver fibrosis to major stroke types including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage at the population level.

Methods: In this large prospective cohort study, participants without previous stroke or coronary heart disease at baseline from the UK Biobank were included.

Postoperative fever after elective minimally invasive resection for gastric and colorectal cancer: incidence, risk factors and characteristics.

Purpose: To analyze the incidence and risk factors of postoperative fever (POF) in gastrointestinal cancer (GIC), discuss the influence of POF on short-term clinical outcomes, and predict anastomotic leakage (AL) based on POF characteristics.

Methods: Overall, 1362 patients that underwent radical resection for GIC were retrospectively analyzed. POF was defined as a postoperative temperature ≥38°C during hospitalization.

A stacking ensemble system for identifying the presence of histological variants in bladder carcinoma: a multicenter study.

Purpose: To create a system to enable the identification of histological variants of bladder cancer in a simple, efficient, and noninvasive manner.

Material And Methods: In this multicenter diagnostic study, we retrospectively collected basic information and CT images about the patients concerned from three hospitals. An interactive deep learning-based bladder cancer image segmentation framework was constructed using the Swin UNETR algorithm for further features extraction.

New evidence for the earliest ornithischian dinosaurs from Asia.

The Early Jurassic ornithischian dinosaurs in Laurasia are dominated by armored dinosaurs, with other early ornithischian groups being rare. Here, a new taxon, gen. et sp.

Ligand-induced changes in the electrocatalytic activity of atomically precise Au nanoclusters.

Atomically precise gold nanoclusters have shown great promise as model electrocatalysts in pivotal electrocatalytic processes such as the hydrogen evolution reaction (HER) and carbon dioxide reduction reaction (CORR). Although the influence of ligands on the electronic properties of these nanoclusters is well acknowledged, the ligand effects on their electrocatalytic performances have been rarely explored. Herein, using [Au(SR)] nanoclusters as a prototype model, we demonstrated the importance of ligand hydrophilicity hydrophobicity in modulating the interface dynamics and electrocatalytic performance.

Cancer-associated fibroblast-derived exosomal FAM83F regulates KIF23 expression to promote the malignant progression and reduce radiosensitivity in non-small cell lung cancer.

Unlabelled: Cancer-associated fibroblasts (CAFs) have been shown to play a crucial role in the progression of non-small cell lung cancer (NSCLC). Exosomes derived from CAFs have emerged as important mediators of intercellular communication in the tumor microenvironment, contributing to cancer progression. Therefore, it is essential to further investigate the mechanisms by which CAF-derived exosomes regulate NSCLC.

Dopamine receptors and organ fibrosis.

Organ fibrosis, considered as a major global health concern, is a pathological condition often occurring after tissue injury in various organs. The pathogenesis of fibrosis involves multiple phases and multiple cell types. Dopamine is involved in various life activities by activating five receptors (D1, D2, D3, D4, D5).

Implementing Cancer Pain Management Training for Pharmacists Using the Kirkpatrick Evaluation Model.

Purpose: To develop a training program on cancer pain management for pharmacists and to evaluate the effectiveness of the training.

Methods: The program developed a well-structured curriculum and subsequent evaluation of training effectiveness, guided by the Kirkpatrick four-tier evaluation model, including reaction, learning, behavior, and results. The training approach incorporated mentoring, study groups, and problem-based learning to create an immersive and impactful learning experience.

A Multifunctional MIL-101-NH(Fe) Nanoplatform for Synergistic Melanoma Therapy.

Background: Melanoma is an aggressive form of skin cancer, and single-modality treatments often fail to prevent tumor recurrence and metastasis. Combination therapy has emerged as an effective approach to improve treatment outcomes.

Methods: In this study, we developed a multifunctional nanoplatform, MIL@DOX@ICG, utilizing MIL-101-NH(Fe) as a carrier to co-deliver the chemotherapeutic agent doxorubicin (DOX) and the photosensitizer indocyanine green (ICG).

Effects of intramuscular fat on the flavor of fresh sheep and goat meat: Recent insights into pre-mortem and post-mortem factors.

Sheep and goat meat products are becoming increasingly popular among consumers due to their unique flavor derived from intramuscular fat (IMF), which contributes to formation of the distinctive odor. However, there is currently a dearth of reviews on the impact of IMF on the flavor of sheep and goat meat. The present review aims to discuss the relationships between IMF and flavor through lipid composition and fatty acid (FA) distribution, provide an overview of characteristic flavor compounds affecting the flavor of sheep and goat meat, and shed light on the impacts of pre-mortem and post-mortem factors on meat flavor attributed to changes in FAs and flavor compounds.

Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models.

Background: Uterine injury can cause uterine scarring, leading to a series of complications that threaten women's health. Uterine healing is a complex process, and there are currently no effective treatments. Although our previous studies have shown that bone marrow mesenchymal stem cells (BMSCs) promote uterine damage repair, the underlying mechanisms remain unclear.

Investigation of Biocrude Production from Spirulina via Catalytic Hydrothermal Liquefaction with the Ru/ZrO-SiO Catalyst.

Hydrothermal liquefaction (HTL) is a promising technology for converting wet biomass to liquid fuels. However, the biocrude yield and quality in this process are unsatisfactory without catalysts. Herein, a Ru/ZrO-SiO catalyst was prepared with the NaBH reducing method for the HTL of .

Mitochondrial genome of : features, RNA editing, and insights into male sterility.

Introduction: Mitochondria are essential organelles that provide energy for plants. They are semi-autonomous, maternally inherited, and closely linked to cytoplasmic male sterility (CMS) in plants. , a widely used medicinal plant from the Caprifoliaceae family, is rich in chlorogenic acid (CGA) and its analogues, which are known for their antiviral and anticancer properties.

Comprehensive analysis reveals PLK3 as a promising immune target and prognostic indicator in glioma.

Background: PLK3, which played an important role in cell cycle progression and stress response, was identified as highly expressed in various carcinomas. However, the functions, molecular characteristics, and prognostic value of PLK3 in glioma remained unexplored.

Methods: We analyzed PLK3 expression in glioma samples from multiple databases.

Association between albumin corrected anion gap and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease.

Background: The relationship between albumin-corrected anion gap (ACAG) and in-hospital mortality in critically ill patients with COPD remains unclear.

Objective: This study investigated the association between ACAG levels and the risk of in-hospital mortality in critically ill patients with COPD.

Design: A retrospective cohort study.

A stereochemical model and origins of selectivity for the rhodium-catalyzed hydroselenation of styrene.

A deeper understanding of the mechanisms underlying transition metal-catalyzed transformation is crucial for developing innovative strategies to synthesize chiral organoselenium compounds. In this study, we developed and investigated a three-layer chirality relay model for the rhodium-catalyzed asymmetric hydroselenation of alkenes through density functional theory (DFT) calculations. In the back layer of this model, the four bulky substituents on the phosphorus atom of the bidentate chiral MeO-BIPHEP ligand were positioned on axial and equatorial bonds, thereby influencing the configuration of the middle layer.

Catalytic CuO/Cu Site Trades off the Coupling and Etching Reactions of Carbon Intermediates for CO-Assisted Graphene Synthesis.

In the chemical vapor deposition (CVD) synthesis of graphene, the surficial chemical state of the metal substrate has exerted key roles in all elemental reaction steps determining the growth mechanism of graphene. Herein, a CO-participated annealing procedure is designed to construct catalytic CuO/Cu sites on Cu foil for the graphene CVD synthesis with CO/CH as carbon sources. These CuO/Cu species can catalyze the CH decomposition and subsequent C─C coupling to form C intermediates for fast growth of monolayer hexagonal graphene domains with a diameter of ≈30 µm within 0.

A NiP/NiMoO nanocone electrocatalyst for efficient hydrogen evolution: tip-enhanced local electric field effect.

The sluggish kinetics of the hydrogen evolution reaction (HER) result in a high overpotential in alkaline solutions. A high-curvature metal oxide heterostructure can effectively boost the electrocatalytic HER by leveraging the tip-enhanced local electric field effect. Herein, NiP/NiMoO nanocones were synthesised on a nickel foam (NF) substrate by etching a metal-organic framework template.

Cycloolefin Copolymers With a Multiply Rigid Structure for Protecting Triplet Exciton From Thermo- and Moisture-Quenching.

Polymeric room temperature phosphorescence (RTP) materials have been well developed and utilized in various fields. However, their fast thermo- and moisture-quenching behavior highly limit their applications in certain harsh environments. Therefore, the preparation of materials with thermo- and moisture-resistant phosphorescence is greatly attractive.

Immune infiltration landscape and potential drug-targeted implications for hepatocellular carcinoma with 'progression/hyper-progression' recurrence.

Background And Aims: Hepatocellular carcinoma (HCC) recurrence was previously characterized into four types, and patients with progression/hyper-progression recurrence (type III-IV) have an extremely poor prognosis. However, the immune background of resectable HCC, particularly in patients who experience recurrence, remains underexplored. Therefore, this study aimed to describe the immune landscape of resectable HCC, especially postoperative type III-IV recurrent HCC, and explore potential immune-targeted anti-relapse strategies for treated populations.

Clinical Utility of Dual-Time Ga-Pentixafor PET/CT in Diagnosing and Subtyping Primary Aldosteronism.

Objectives: This study aimed to compare the clinical efficacy of dual-time Ga-pentixafor PET/CT with adrenal vein sampling (AVS) in PA lateralization.

Methods And Methods: We retrospectively analysed 161 patients with PA. We assessed the diagnostic performance of dual-time Ga-pentixafor PET/CT in diagnosing unilateral primary aldosteronism (UPA) and aldosterone-producing adenoma (APA).