521 results match your criteria: "Chongqing Traditional Chinese Medicine Hospital.[Affiliation]"

Article Synopsis
  • Genetic factors may significantly impact erectile dysfunction (ED), but identifying specific genes remains challenging due to limited research.
  • A study used data from the Finnish database Finngen, analyzing 1154 ED cases and 94,024 controls through Mendelian randomisation, highlighting potential pathogenic genes.
  • Among 110 identified genes, MDM4 was found to have the strongest association with ED risk, suggesting it could play an important role in personalized treatment strategies for patients.
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Background: Seawater drowning is a leading cause of accidental injury and death, and the resulting acute lung injury (ALI) is a serious clinical syndrome for which there are no effective treatments. This study aims to investigate the potential mechanism of seawater drowning-induced ALI.

Methods: Seawater drowning mouse models were constructed to assess lung injury.

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  • The study investigates the turnover intentions of registered male nurses in China, highlighting a significant increase in this workforce yet a lack of research on their job stability.
  • About 71.6% of male nurses reported medium to high turnover intentions, influenced by factors like family status, occupational prestige, work values, income satisfaction, and career development.
  • The findings emphasize the need for targeted interventions addressing unique factors beyond typical job concerns to improve job satisfaction and retention among male nurses in China.
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Background: The hypothalamus has been recognized as a core structure in the sleep-wake cycle. However, whether the neuroplasticity of the hypothalamus is involved in the acupuncture treatment of insomnia remains elusive.

Methods: We recruited 42 patients with chronic insomnia disorder (CID) and 23 matched healthy controls (HCs), with CID patients randomly assigned to receive real acupuncture (RA) or sham acupuncture (SA) for four weeks.

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Background: Pneumothorax is a potential complication following computed tomography-guided lung biopsy (CT-LB). However, the relationship between the lung needle path CT attenuation values and risk of post-procedural immediate pneumothorax remains unclear. The study aims to investigate this relationship.

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Septic cardiomyopathy (SCM) is a critical complication of sepsis, primarily attributed to mitochondrial dysfunction and impaired autophagic flux. This study explores the role of translocator protein (TSPO) in SCM pathogenesis and assesses its potential as a therapeutic target. We identified increased TSPO expression in plasma samples from sepsis patients, with further validation in septic rats and LPS-stimulated H9C2 cardiomyocytes.

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Background And Objectives: This study aimed to employ machine learning techniques to predict the clinical efficacy of acupuncture as an intervention for patients with upper limb motor dysfunction following ischemic stroke, as well as to assess its potential utility in clinical practice.

Methods: Medical records and digital subtraction angiography (DSA) imaging data were collected from 735 ischemic stroke patients with upper limb motor dysfunction who were treated with standardized acupuncture at two hospitals. Following the initial screening, 314 patient datasets that met the inclusion criteria were selected.

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Comparison of different processed products of for the treatment of mice asthenozoospermia.

Transl Androl Urol

October 2024

Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, China.

Article Synopsis
  • GZP, a co-processed mixture with salt and wine, effectively treats asthenozoospermia (reduced sperm motility) in mice by enhancing sexual function and testicular health.
  • The study involved establishing a mouse model for the condition and testing six products, revealing GZP significantly improves sperm count, survival, and reduces deformities.
  • GZP appears to work by inhibiting excessive mitophagy and maintaining mitochondrial integrity, reducing harmful reactive oxygen species (ROS), and blocking certain protein expressions related to cell death.
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  • The inflammatory response is crucial in causing acute exacerbations of chronic obstructive pulmonary disease (AECOPD), and managing it can enhance patient outcomes.
  • A study assessed the impact of a herbal decoction (QHD) on lung function and inflammatory markers in AECOPD patients through a meta-analysis of 40 randomized controlled trials.
  • Results showed that QHD significantly improved lung function and reduced inflammation without increasing side effects, suggesting it could be a beneficial treatment option for AECOPD.
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The endoplasmic reticulum (ER) is a dynamic organelle that is a site of the synthesis of proteins and lipids, contributing to the regulation of proteostasis, lipid metabolism, redox balance, and calcium storage/-dependent signaling events. The disruption of ER homeostasis due to the accumulation of misfolded proteins in the ER causes ER stress which activates the unfolded protein response (UPR) system through the activation of IRE1, PERK, and ATF6. Activation of UPR is observed in various cancers and therefore, its association with process of carcinogenesis has been of importance.

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Asiatic acid inhibits HBV cccDNA transcription by promoting HBx degradation.

Virol J

October 2024

Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Article Synopsis
  • Hepatitis B virus (HBV) infection is a significant global health issue, and current antiviral treatments face challenges, making targeting the HBx protein a potential solution for developing new therapies.
  • A study utilized the Nano-Glo HiBiT Lysis Detection System to screen for herbal compounds that inhibit HBx, with asiatic acid from Centella asiatica showing promising results in reducing HBx levels and HBV activity in infected cells and mice.
  • Findings suggest that asiatic acid works by promoting HBx degradation through autophagy, leading to decreased HBV transcription and establishing it as a potential anti-HBV treatment.
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Myocardial ischemia-reperfusion injury (MIRI) significantly worsens the outcomes of patients with cardiovascular diseases. Dexmedetomidine (Dex) is recognized for its cardioprotective properties, but the related mechanisms, especially regarding metabolic reprogramming, have not been fully clarified. A total of 60 patients with heart valve disease are randomly assigned to Dex or control group.

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Background: Management of moderate-to-severe atopic dermatitis (AD) needs long-term therapy. Stapokibart is a humanized monoclonal antibody targeting interleukin-4 receptor α subunit (IL-4Rα), a shared receptor for IL-4 and IL-13 which are key pathogenic drivers of AD. In a pivotal phase 3 trial (NCT05265923), significant higher proportions of adult AD patients receiving stapokibart than placebo achieved ≥75% improvement from baseline in Eczema Area and Severity Index (EASI-75; 66.

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In this study, we genotyped 939 unrelated healthy individuals to investigate the genetic polymorphisms of 38 Y chromosome short tandem repeats(Y-STRs) loci included in the Yfiler™ Platinum kit in the Hui population of Shaanxi Province. Comprehensive population comparisons were performed using analysis of molecular variance(AMOVA), multidimensional scaling(MDS), and molecular evolutionary genetics analysis(MEGA) to explore population relationships. The allele frequencies of the single-copy loci ranged from 0.

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Targeting inflammation and gut microbiota with antibacterial therapy: Implications for central nervous system health.

Ageing Res Rev

December 2024

Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Department of Cardiology, the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical Electrophysiology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:

The complex symbiotic relationship between inflammation, the gut microbiota, and the central nervous system (CNS) has become a pivotal focus of contemporary biomedical research. Inflammation, as a physiological defense mechanism, plays a dual role as both a protective and pathological factor, and is intricately associated with gut microbiota homeostasis, often termed the "second brain." The gutbrain axis (GBA) exemplifies this multifaceted interaction, where gut health exerts significantly regulatory effects on CNS functions.

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Association between malnutrition risk and the prognosis of geriatric heart failure patients undergoing left ventricular assist device implantation.

J Nutr Health Aging

December 2024

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Article Synopsis
  • A study was conducted to explore the relationship between malnutrition risk and the outcomes of older heart failure patients (65+) who received left ventricular assist devices (LVAD) using data from the INTERMACS registry.
  • *The research involved a retrospective analysis of 5,429 patients, revealing that a significant percentage faced malnutrition risk, which was linked to higher mortality rates and poorer health outcomes over time.
  • *Key findings indicated that moderate-to-severe malnutrition risk both before and after LVAD implantation correlated with increased death risk, infections, and lower quality of life among patients.
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Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large-Scale Genome-Wide Cross-Trait Analysis.

Mol Genet Genomic Med

October 2024

Guangdong Academy of Traditional Chinese Medicine, Research Team of Bio-Molecular and System Biology of Chinese Medicine, Guangzhou, China.

Article Synopsis
  • Bullous pemphigoid (BP) and atopic dermatitis (AD) are connected, but more research is needed to understand their co-morbidities.* -
  • Analysis using data from large genetic studies found a significant genetic correlation between BP and AD, along with shared loci and genes.* -
  • The results suggest that BP may increase the risk of developing AD, providing crucial insights for dermatologists in patient management.*
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In the recent history of the SARS-CoV-2 outbreak, vaccines have been a crucial public health tool, playing a significant role in effectively preventing infections. However, improving the efficacy while minimizing side effects remains a major challenge. In recent years, there has been growing interest in nanoparticle-based delivery systems aimed at improving antigen delivery efficiency and immunogenicity.

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Background: The development of biomaterials capable of accelerating bone wound repair is a critical focus in bone tissue engineering. This study aims to evaluate the osteointegration and bone regeneration potential of a novel multilayer gelatin-supported Bone Morphogenetic Protein 9 (BMP-9) coated nano-calcium-deficient hydroxyapatite/poly-amino acid (n-CDHA/PAA) composite biomaterials, focusing on the material-bone interface, and putting forward a new direction for the research on the interface between the coating material and bone.

Methods: The BMP-9 recombinant adenovirus (Adenovirus (Ad)-BMP-9/Bone Marrow Mesenchymal Stem Cells (BMSc)) was produced by transfecting BMSc and supported using gelatin (Ad-BMP-9/BMSc/Gelatin (GT).

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The impact of moral resilience on nurse turnover intentions: the mediating role of job burnout in a cross-sectional study.

BMC Nurs

September 2024

Chongqing Center for Evidence-based Traditional Chinese Medicine, Chongqing Traditional Chinese Medicine Hospital, No.6 of Panxi 7th Branch Road, Jiangbei District, Chongqing, 400030, China.

Article Synopsis
  • High nursing staff turnover negatively affects care quality and patient safety, making it essential to understand the reasons behind nurses' intentions to leave their jobs.
  • This study investigates how moral resilience and job burnout relate to turnover intentions among nurses, specifically examining job burnout as a mediating factor.
  • Data from 322 registered nurses showed that higher moral resilience is linked to lower job burnout and turnover intentions, with job burnout fully mediating this relationship.
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Article Synopsis
  • China faces a significant challenge with postherpetic neuralgia, necessitating effective new treatment options that minimize neurotoxic effects compared to current calcium channel ligands.
  • The study aimed to evaluate the efficacy and safety of crisugabalin, a new oral medication, involving a randomized clinical trial across 48 care centers in China, which included a 12-week treatment phase and a subsequent 14-week extension phase.
  • Results showed improvement in pain relief for patients taking crisugabalin, particularly at the 40 mg and 80 mg doses, highlighting its potential as a more effective treatment for managing postherpetic neuralgia compared to a placebo.
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Article Synopsis
  • This research focuses on the role of the ADCY5 gene in glioblastoma (GBM), examining its expression, epigenetic changes, and how these factors impact patient prognosis.
  • ADCY5 was found to be downregulated in GBM tissues and cell lines, and its lower expression correlates with higher DNA methylation and poorer patient outcomes.
  • Restoring ADCY5 expression reduced GBM cell growth and migration, indicating its potential as a therapeutic target in combating GBM.
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Hederagenin inhibits mitochondrial damage in Parkinson's disease via mitophagy induction.

Free Radic Biol Med

November 2024

School of Pharmacy, Department of Pharmacy, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Gui Yang, 550000, China. Electronic address:

Background: Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons and the formation of α-synuclein aggregates. Mitochondrial dysfunction and oxidative stress are pivotal in PD pathogenesis, with impaired mitophagy contributing to the accumulation of mitochondrial damage. Hederagenin (Hed), a natural triterpenoid, has shown potential neuroprotective effects; however, its mechanisms of action in PD models are not fully understood.

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In recent years, growth hormone and insulin-like growth factors have become key regulators of bone metabolism and remodeling, crucial for maintaining healthy bone mass throughout life. Studies have shown that adult growth hormone deficiency leads to alterations in bone remodeling, significantly affecting bone microarchitecture and increasing fracture risk. Although recombinant human growth hormone replacement therapy can mitigate these adverse effects, improving bone density, and reduce fracture risk, its effectiveness in treating osteoporosis, especially in adults with established growth hormone deficiency, seems limited.

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