521 results match your criteria: "Chongqing Traditional Chinese Medicine Hospital.[Affiliation]"
Am J Clin Exp Urol
October 2024
Department of Urology, Chongqing Traditional Chinese Medicine Hospital Chongqing 400000, The People's Republic of China.
J Thorac Dis
October 2024
Department of Pediatrics of Jiangbei Campus, The First Affiliated Hospital of Army Medical University (The 958th Hospital of Chinese People's Liberation Army), Chongqing, China.
Background: Seawater drowning is a leading cause of accidental injury and death, and the resulting acute lung injury (ALI) is a serious clinical syndrome for which there are no effective treatments. This study aims to investigate the potential mechanism of seawater drowning-induced ALI.
Methods: Seawater drowning mouse models were constructed to assess lung injury.
BMC Nurs
November 2024
Nursing Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100013, China.
BMC Complement Med Ther
November 2024
School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, No.37 Shierqiao Road, Chengdu, 610075, Sichuan, China.
Background: The hypothalamus has been recognized as a core structure in the sleep-wake cycle. However, whether the neuroplasticity of the hypothalamus is involved in the acupuncture treatment of insomnia remains elusive.
Methods: We recruited 42 patients with chronic insomnia disorder (CID) and 23 matched healthy controls (HCs), with CID patients randomly assigned to receive real acupuncture (RA) or sham acupuncture (SA) for four weeks.
BMC Pulm Med
November 2024
Department of Radiology, Chongqing General Hospital, Yubei District, Chongqing, 401147, China.
Background: Pneumothorax is a potential complication following computed tomography-guided lung biopsy (CT-LB). However, the relationship between the lung needle path CT attenuation values and risk of post-procedural immediate pneumothorax remains unclear. The study aims to investigate this relationship.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China. Electronic address:
Septic cardiomyopathy (SCM) is a critical complication of sepsis, primarily attributed to mitochondrial dysfunction and impaired autophagic flux. This study explores the role of translocator protein (TSPO) in SCM pathogenesis and assesses its potential as a therapeutic target. We identified increased TSPO expression in plasma samples from sepsis patients, with further validation in septic rats and LPS-stimulated H9C2 cardiomyocytes.
View Article and Find Full Text PDFChin Med
November 2024
School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Background And Objectives: This study aimed to employ machine learning techniques to predict the clinical efficacy of acupuncture as an intervention for patients with upper limb motor dysfunction following ischemic stroke, as well as to assess its potential utility in clinical practice.
Methods: Medical records and digital subtraction angiography (DSA) imaging data were collected from 735 ischemic stroke patients with upper limb motor dysfunction who were treated with standardized acupuncture at two hospitals. Following the initial screening, 314 patient datasets that met the inclusion criteria were selected.
Transl Androl Urol
October 2024
Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, China.
Front Pharmacol
October 2024
Department of Classic Traditional Chinese Medicine, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Biochim Biophys Acta Mol Cell Res
January 2025
Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address:
The endoplasmic reticulum (ER) is a dynamic organelle that is a site of the synthesis of proteins and lipids, contributing to the regulation of proteostasis, lipid metabolism, redox balance, and calcium storage/-dependent signaling events. The disruption of ER homeostasis due to the accumulation of misfolded proteins in the ER causes ER stress which activates the unfolded protein response (UPR) system through the activation of IRE1, PERK, and ATF6. Activation of UPR is observed in various cancers and therefore, its association with process of carcinogenesis has been of importance.
View Article and Find Full Text PDFVirol J
October 2024
Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Adv Sci (Weinh)
December 2024
Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Myocardial ischemia-reperfusion injury (MIRI) significantly worsens the outcomes of patients with cardiovascular diseases. Dexmedetomidine (Dex) is recognized for its cardioprotective properties, but the related mechanisms, especially regarding metabolic reprogramming, have not been fully clarified. A total of 60 patients with heart valve disease are randomly assigned to Dex or control group.
View Article and Find Full Text PDFAllergy
October 2024
Department of Dermatology, Peking University People's Hospital, Beijing, China.
Background: Management of moderate-to-severe atopic dermatitis (AD) needs long-term therapy. Stapokibart is a humanized monoclonal antibody targeting interleukin-4 receptor α subunit (IL-4Rα), a shared receptor for IL-4 and IL-13 which are key pathogenic drivers of AD. In a pivotal phase 3 trial (NCT05265923), significant higher proportions of adult AD patients receiving stapokibart than placebo achieved ≥75% improvement from baseline in Eczema Area and Severity Index (EASI-75; 66.
View Article and Find Full Text PDFHeliyon
October 2024
Faculty of Basic Medical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, China.
In this study, we genotyped 939 unrelated healthy individuals to investigate the genetic polymorphisms of 38 Y chromosome short tandem repeats(Y-STRs) loci included in the Yfiler™ Platinum kit in the Hui population of Shaanxi Province. Comprehensive population comparisons were performed using analysis of molecular variance(AMOVA), multidimensional scaling(MDS), and molecular evolutionary genetics analysis(MEGA) to explore population relationships. The allele frequencies of the single-copy loci ranged from 0.
View Article and Find Full Text PDFAgeing Res Rev
December 2024
Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Department of Cardiology, the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical Electrophysiology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:
The complex symbiotic relationship between inflammation, the gut microbiota, and the central nervous system (CNS) has become a pivotal focus of contemporary biomedical research. Inflammation, as a physiological defense mechanism, plays a dual role as both a protective and pathological factor, and is intricately associated with gut microbiota homeostasis, often termed the "second brain." The gutbrain axis (GBA) exemplifies this multifaceted interaction, where gut health exerts significantly regulatory effects on CNS functions.
View Article and Find Full Text PDFJ Nutr Health Aging
December 2024
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Mol Genet Genomic Med
October 2024
Guangdong Academy of Traditional Chinese Medicine, Research Team of Bio-Molecular and System Biology of Chinese Medicine, Guangzhou, China.
Front Immunol
October 2024
College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
In the recent history of the SARS-CoV-2 outbreak, vaccines have been a crucial public health tool, playing a significant role in effectively preventing infections. However, improving the efficacy while minimizing side effects remains a major challenge. In recent years, there has been growing interest in nanoparticle-based delivery systems aimed at improving antigen delivery efficiency and immunogenicity.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
September 2024
Department of Orthopedics, Chongqing Traditional Chinese Medicine Hospital, 400021 Chongqing, China.
Background: The development of biomaterials capable of accelerating bone wound repair is a critical focus in bone tissue engineering. This study aims to evaluate the osteointegration and bone regeneration potential of a novel multilayer gelatin-supported Bone Morphogenetic Protein 9 (BMP-9) coated nano-calcium-deficient hydroxyapatite/poly-amino acid (n-CDHA/PAA) composite biomaterials, focusing on the material-bone interface, and putting forward a new direction for the research on the interface between the coating material and bone.
Methods: The BMP-9 recombinant adenovirus (Adenovirus (Ad)-BMP-9/Bone Marrow Mesenchymal Stem Cells (BMSc)) was produced by transfecting BMSc and supported using gelatin (Ad-BMP-9/BMSc/Gelatin (GT).
BMC Nurs
September 2024
Chongqing Center for Evidence-based Traditional Chinese Medicine, Chongqing Traditional Chinese Medicine Hospital, No.6 of Panxi 7th Branch Road, Jiangbei District, Chongqing, 400030, China.
Rheumatology (Oxford)
September 2024
Chongqing Traditional Chinese Medicine Hospital-Department of Rheumatology, Chongqing, China.
JAMA Dermatol
November 2024
Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.
Heliyon
September 2024
Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, China.
Free Radic Biol Med
November 2024
School of Pharmacy, Department of Pharmacy, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Gui Yang, 550000, China. Electronic address:
Background: Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons and the formation of α-synuclein aggregates. Mitochondrial dysfunction and oxidative stress are pivotal in PD pathogenesis, with impaired mitophagy contributing to the accumulation of mitochondrial damage. Hederagenin (Hed), a natural triterpenoid, has shown potential neuroprotective effects; however, its mechanisms of action in PD models are not fully understood.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
June 2024
Department of Endocrinology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
In recent years, growth hormone and insulin-like growth factors have become key regulators of bone metabolism and remodeling, crucial for maintaining healthy bone mass throughout life. Studies have shown that adult growth hormone deficiency leads to alterations in bone remodeling, significantly affecting bone microarchitecture and increasing fracture risk. Although recombinant human growth hormone replacement therapy can mitigate these adverse effects, improving bone density, and reduce fracture risk, its effectiveness in treating osteoporosis, especially in adults with established growth hormone deficiency, seems limited.
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