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Effect of advanced glycation end products on autophagic ability in osteoblasts.

Zhong Nan Da Xue Xue Bao Yi Xue Ban

April 2021

Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing 401145.

Objectives: Excessive production of AGEs in diabetic patients will affect the normal function of osteoblasts, and this process may be related to autophagy of osteoblasts. This study aims to explore the effect of advanced glycation end products (AGEs) on autophagic activity during osteogenic differentiation in rat bone marrow mesenchymal stem cells (BMSCs).

Methods: BMSCs were isolated and cultured in vitro, treated with different concentrations (0, 50, 100, 200, and 400 mg/L) of AGEs for different time (3, 6, 12, 24, 48, and 72 h).

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