Acetaminophen administration reduces acute kidney injury risk in critically ill patients with Clostridium difficile infection: A cohort study.

Background: Acetaminophen serves as a standard antipyretic and analgesic agent in the intensive care unit (ICU). However, the association between its administration and acute kidney injury (AKI) among critically ill patients remains controversial, particularly lacking research in patients with Clostridioides difficile infection (CDI). Our aim was to explore the potential relationship between early acetaminophen administration and AKI in critically ill patients with concurrent CDI.

Invasive Eye Infection Caused by Trichoderma Harzianum.

Trichoderma is a widely distributed thermophilic fungus that grows on moist soil, fallen leaves, and rotten wood. It plays an important role in agricultural production, food processing, and soil. However, some forms of Trichoderma can infect humans.

Understanding the Role of Potential and Cation Effect on Electrocatalytic CO Reduction in All-Alkynyl-Protected Ag Nanoclusters.

Atomically precise metal nanoclusters (NCs) have emerged as an intriguing class of model catalysts for electrochemical CO reduction reactions (CORR). However, the interplay between the interface environment (e.g.

Machine Learning-Assisted High-Donor-Number Electrolyte Additive Screening toward Construction of Dendrite-Free Aqueous Zinc-Ion Batteries.

The utilization of electrolyte additives has been regarded as an efficient strategy to construct dendrite-free aqueous zinc-ion batteries (AZIBs). However, the blurry screening criteria and time-consuming experimental tests inevitably restrict the application prospect of the electrolyte additive strategy. With the rise of artificial intelligence technology, machine learning (ML) provides an avenue to promote upgrading of energy storage devices.

Effects of Acceptance and Commitment Care in the Treatment of Aplastic Anemia Patients with Recombinant Human Thrombopoietin.

Background: This study was designed to determine the effects of acceptance and commitment care in the treatment of aplastic anemia (AA) patients with recombinant human thrombopoietin (rhTPO).

Methods: The clinical records of 100 AA patients treated at our hospital from March 2021 to March 2023 were analyzed in the retrospective study. All patients received immunosuppressants and rhTPO.

Differential Expression of miR-26b-5p, EGR1, and STAT1 in Peripheral Blood of Schizophrenia Patients.

Background: This study aimed to investigate miRNAs and upstream regulatory transcription factors involved in schizophrenia (SZ) pathogenesis.

Methods: Differential expression of miRNAs and genes in SZ patients was investigated utilizing the gene expression omnibus dataset, gene ontology annotations, and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. Real-time quantitative polymerase chain reaction experiments were conducted to validate the predictive screening of regulatory genes in peripheral blood samples from 20 SZ patients and 20 healthy controls.

Style Transfer of Chinese Wuhu Iron Paintings Using Hierarchical Visual Transformer.

Within the domain of traditional art, Chinese Wuhu Iron Painting distinguishes itself through its distinctive craftsmanship, aesthetic expressiveness, and choice of materials, presenting a formidable challenge in the arena of stylistic transformation. This paper introduces an innovative Hierarchical Visual Transformer (HVT) framework aimed at achieving effectiveness and precision in the style transfer of Wuhu Iron Paintings. The study begins with an in-depth analysis of the artistic style of Wuhu Iron Paintings, extracting key stylistic elements that meet technical requirements for style conversion.

ppb-Level SO Photoacoustic Sensor for SF Decomposition Analysis Utilizing a High-Power UV Laser with a Power Normalization Method.

A highly sensitive sulfur dioxide (SO) photoacoustic gas sensor was developed for the sulfur hexafluoride (SF) decomposition detection in electric power systems by using a novel 266 nm low-cost high-power solid-state pulse laser and a high -factor differential photoacoustic cell. The ultraviolet (UV) pulse laser is based on a passive -switching technology with a high output power of 28 mW. The photoacoustic signal was normalized to the laser power to solve the fluctuation of the photoacoustic signal due to the power instability of the UV laser.

Study on the Carrier Transport Process in Deep Ultraviolet Light-Emitting Diodes with Al-Content-Varied AlGaN Composite Last Quantum Barrier.

Serious electron leakage and poor hole injection efficiency are still challenges for deep ultraviolet AlGaN-based light-emitting diodes with a traditional structure in achieving high performance. Currently, the majority of research works concentrate on optimizing the structures of the electron blocking layer (EBL) and last quantum barrier (LQB) separately, rather than considering them as an integrated structure. Therefore, in this study, an Al-content-varied AlGaN composite last quantum barrier (CLQB) layer is proposed to replace the traditional EBL and LQB layers.

Editorial for the Special Issue on Advanced Micro- and Nano-Manufacturing Technologies.

With the continuous advancement of science and technology, micro- and nano-manufacturing technologies have become frontier fields in modern manufacturing [...

Study on the Bending and Shear Behavior of a New Type of Wet Joint in Precast Concrete Deck for Composite Bridges.

According to the mechanical characteristics of joints in steel-concrete composite bridge decks under the combined bending and shear, improved joint details with simple structure and convenient construction were studied, including lapped U-bars, lapped headed bars, and lapped hook bars. In order to test the mechanical properties of the three joint details and compare them with the existing lapped/welded linear bars, the tests of five specimens were carried out. The cracking load, ultimate load, failure mode, crack pattern, and reinforcement strain were analyzed.

Investigation of Shear Behavior in High-Strength Bolt Connectors for Steel-Concrete Composite Beams.

High-strength bolt connectors, known for their robust strength and ease of disassembly, are suitable not only for the construction of new steel-concrete composite beams but also for reinforcing existing composite or steel beams. Static push-out tests were performed on nine specimens to examine their shear behavior. The primary failure mode was observed at the steel-concrete interface, characterized by the tensile-shear failure of the bolt and localized crushing of the concrete beneath the bolt.

A Wide Passband Frequency-Selective Surface with a Sharp Roll-Off Band Using the Filtering Antenna-Filtering Antenna Method.

Frequency-selective surfaces (FSSs) have attracted great attention owing to their unique feature to manipulate transmission performance over the frequency domain. In this work, a filtering antenna-filtering antenna (FA-FA) FSS with a wide passband and double-side sharp roll-off characteristics is presented by inter-using the filtering antenna and receiving-transmitting metasurface methods. First, a dual-polarized filtering antenna element was designed by employing a parasitic band-stop structure with an L-probe feed.

Empirical Comparison and Analysis of Artificial Intelligence-Based Methods for Identifying Phosphorylation Sites of SARS-CoV-2 Infection.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the large coronavirus family with high infectivity and pathogenicity and is the primary pathogen causing the global pandemic of coronavirus disease 2019 (COVID-19). Phosphorylation is a major type of protein post-translational modification that plays an essential role in the process of SARS-CoV-2-host interactions. The precise identification of phosphorylation sites in host cells infected with SARS-CoV-2 will be of great importance to investigate potential antiviral responses and mechanisms and exploit novel targets for therapeutic development.

The Induction of Disease Resistance by Scopolamine and the Application of Extract Against Potato ( L.) Late Blight.

Late blight, caused by , is a devastating disease of potato. Our previous work illustrated that scopolamine, the main bioactive substance of extract, exerts direct inhibitory effects on , but it is unclear whether scopolamine and extract can boost resistance to late blight in potato. In this study, .

SlUPA-like, a bHLH Transcription Factor in Tomato (), Serves as the Crosstalk of GA, JA and BR.

The bHLH (basic Helix-Loop-Helix) transcription factor serves as pivotal controller in plant growth and development. In a previous study, the overexpression of in L. Ailsa Craig (AC) altered the JA (Jasmonic acid) response and endogenous GA (Gibberellic acid) content.

Emotion Recognition Model of EEG Signals Based on Double Attention Mechanism.

Background: Emotions play a crucial role in people's lives, profoundly affecting their cognition, decision-making, and interpersonal communication. Emotion recognition based on brain signals has become a significant challenge in the fields of affective computing and human-computer interaction.

Methods: Addressing the issue of inaccurate feature extraction and low accuracy of existing deep learning models in emotion recognition, this paper proposes a multi-channel automatic classification model for emotion EEG signals named DACB, which is based on dual attention mechanisms, convolutional neural networks, and bidirectional long short-term memory networks.

Integrating network pharmacology to investigate the mechanism of quercetin's action through AKT inhibition in co-expressed genes associated with polycystic ovary syndrome and endometrial cancer.

Endometrial cancer (EC) is a common gynecological malignancy for which polycystic ovarian syndrome (PCOS) has been identified as a significant risk factor. Quercetin, a widely distributed natural flavonoid, has demonstrated potential therapeutic effects in managing both PCOS and EC. However, the specific molecular targets of quercetin in the context of PCOS comorbid with EC (PCOS-EC) remain poorly defined.

Solution processable triarylamine-based polyamide for electrochromic supercapacitors and smart displays with energy reuse.

Electrochromic (EC) materials based on ion insertion/desertion mechanisms provide a possibility for energy storage. Solution-processable energy storage EC polyamides have great potential for use in smart displays and EC supercapacitors. A suitable monomer structure design is particularly important for enhancing the electrochemical properties of polyamides.

Searching for new drugs to treat Alzheimer's disease dementia through multiple pathways.

Dementia is a group of diseases, including Alzheimer's disease (AD), vascular dementia, Lewy body dementia, frontotemporal dementia, Parkinson's disease dementia, metabolic dementia and toxic dementia. The treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms, nutritional support therapy for repairing nerve cells, psychological auxiliary treatment, and treatment that improves cognitive function through drugs. Among them, drug therapy to improve cognitive function is important.

The value of radiomics-based hyperdense middle cerebral artery sign in predicting hemorrhagic transformation in acute ischemic stroke patients undergoing endovascular treatment.

Objective: To establish and validate a model based on hyperdense middle cerebral artery sign (HMCAS) radiomics features for predicting hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS) after endovascular treatment (EVT).

Methods: Patients with AIS who presented with HMCAS on non-contrast computed tomography (NCCT) at admission and underwent EVT at three comprehensive hospitals between June 2020 and January 2024 were recruited for this retrospective study. A radiomics model was constructed using the HMCAS radiomics features most strongly associated with HT.

Dynamic changes and prognostic value of glutathione S-transferase alpha in mild cognitive impairment and Alzheimer's disease.

Objectives: Glutathione S-transferase alpha (GSTα) is an important antioxidant enzyme closely associated with the onset and progression of neurodegenerative diseases. The alterations in GSTα protein levels associated with Alzheimer's disease and their impact on cognitive abilities remain unclear. Thus, investigating the fluctuations of GSTα protein levels in mild cognitive impairment (MCI) and Alzheimer's disease (AD) is essential.

Photoexcited Electro-Driven Reactive Oxygen Species Channeling for Precise Extraction of Biomarker Information from Tumor Interstitial Fluid.

Direct electrochemical detection of miRNA biomarkers in tumor tissue interstitial fluid (TIF) holds great promise for adjuvant therapy for tumors in the perioperative period, yet is limited by background interference and weak signal. Herein, a wash-free and separation-free miRNA biosensor based on photoexcited electro-driven reactive oxygen channeling analysis (LEOCA) is developed to solve the high-fidelity detection in physiological samples. In the presence of miRNA, nanoacceptors (ultrasmall-size polydopamine, uPDA) are responsively assembled on the surface of nanodonors (zirconium metal-organic framework, ZrMOF) to form core-satellite aggregates.

Prevalence and influencing factors of the dyadic psychological stress among patients with lung cancer and their family caregivers: a cross-sectional study.

Background: A lung cancer diagnosis has a huge impact on the psychological well-being of both patients and family caregivers. However, the current psychological stress status among dyads remains unclear. We aimed to determine the prevalence of anxiety and depression and identify the factors that influence patients with lung cancer and their caregivers.