Confined CVD Synthesis and Temperature-Dependent Spectroscopic Properties of Bilayer Graphene Ribbon Arrays with Bifunctional Modulation of Adhesion Metal.

Bilayer graphene ribbons (GRs) hold great promise for the fabrication of next-generation nanodevices, thanks to unparalleled electronic properties, especially the tunable bandgap in association with twist angle, ribbon width, edge structure, and interlayer coupling. A common challenge in manufacturing bilayer GRs via templated chemical vapor deposition (CVD) approach is uncontrollable dewetting of micro- and nano-scaled patterned metal substrates. Herein, a confined CVD synthetic strategy of bilayer GR arrays is proposed, by utilizing the bifunctional Ni as a buffered adhesion layer to regulate the anisotropic dewetting of metal film in the V-groove and as a carbon-dissolution regulated metal to initiate the bilayer nucleation.

Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating GG.

Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With the growing knowledge about the gut-bone axis, the therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. Although GG (LGG) is widely reported to positively regulate bone metabolism by restoring the dysbiotic microbiome, oral administration is associated with sensitivity to gastric fluid and low bioavailability.

High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis.

Background: Abundant research indicates that increased extracellular matrix (ECM) stiffness significantly enhances the malignant characteristics of hepatocellular carcinoma (HCC) cells. Plectin, an essential cytoskeletal linker protein, has recently emerged as a promoter of cancer progression, particularly in the context of cancer cell invasion and metastasis. However, the responsiveness of plectin to changes in ECM stiffness and its impact on HCC progression remain unclear.

Interpretable CT Radiomics-based Machine Learning Model for Preoperative Prediction of Ki-67 Expression in Clear Cell Renal Cell Carcinoma.

Rationale And Objectives: To develop and externally validate interpretable CT radiomics-based machine learning (ML) models for preoperative Ki-67 expression prediction in clear cell renal cell carcinoma (ccRCC).

Methods: 506 patients were retrospectively enrolled from three independent institutes and divided into the training (n=357) and external test (n=149) sets. Ki67 expression was determined by immunohistochemistry (IHC) and categorized into low (<15%) and high (≥15%) expression groups.

Multi-pass cavity-enhanced Raman spectroscopy of complex natural gas components.

Background: The concentration of natural gas components significantly impacts the transportation, storage, and utilization of natural gas. Consequently, implementing online monitoring and leak detection systems is vital to guarantee the efficient use of natural gas and to uphold its safe and stable operation. Raman spectroscopy offers distinctive benefits, including high selectivity, superior precision, and the capability to detect multiple gas components simultaneously using a single-wavelength laser.

Early identification of potentially reversible cancer cachexia using explainable machine learning driven by body weight dynamics: a multicenter cohort study.

Background: Cachexia is associated with multiple adverse outcomes in cancer. However, clinical decision-making for oncology patients at the cachexia stage presents significant challenges.

Objectives: This study aims to develop a machine learning (ML) model to identify potentially reversible cancer cachexia (PRCC).

UV-activated acetylene sensor based on WO/NiO-modified ZnO heterostructures with good stability in transformer oil.

Dissolved gas analysis (DGA) is an effective method for diagnosing potential faults in oil-immersed power transformers. Metal oxide semiconductor (MOS) gas sensors exhibit excellent performance. However, high operating temperatures can accelerate device aging, thereby reducing the reliability of online monitoring.

Palladium-Catalyzed Stereospecific Glycosylation Enables Divergent Synthesis of N-O-Linked Glycosides.

We present a versatile palladium-catalyzed glycosylation platform that enables facile access to structurally diverse N-O-linked glycosides with constantly excellent regio- and stereoselectivities. Importantly, this approach offers a broad substrate scope, low catalyst loadings, and outstanding chemoselectivity, allowing for the selective reaction of oximes/hydroximic acids over hydroxyl groups that would otherwise pose challenges in conventional glycosylation methods. The synthetic utility of this method is further exemplified through a range of synthetic transformations and late-stage modification of bioactive molecules.

A SERS and colorimetric dual-mode biosensor based on stimulus-responsive DNA/MOF-bound bimetallic nanozyme for the ultrasensitive detection of chloramphenicol in food.

A dual-mode detection platform utilizing colorimetric and Raman was developed based on the exponential amplification reaction (EXPAR) strategy and a "core-satellite" structure constructed by bimetallic nanozymes to detect chloramphenicol (CAP). Initially, DNA-gated metal-organic frameworks (MOFs) incorporating cascaded amplification were used to be nanocarriers for the colorimetric and Raman reporter molecules (3,3',5,5'-tetramethylbiphenyl; TMB). Subsequently, assembled DNA served as gatekeepers to create a stimulus-responsive DNA-gated MOF (TMB@DNA/MOF).

β-Thioamide Sulfone Enabled Copper-Catalyzed Ring-Opening/Sulfonylation of Cyclopropenes: Access to Alkyl Aryl Sulfones.

Sulfone motifs play important roles in bioactive compounds and functional materials. The development of efficient methodologies for constructing sulfonyl-containing compounds has thus attracted considerable attention. Here, we introduce a protocol for the preparation of alkyl aryl sulfones under mild conditions.

Autophagy intersection: Unraveling the role of the SNARE complex in lysosomal fusion in Alzheimer's disease.

Autophagy is a fundamental cellular process critical for maintaining neuronal health, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD). This review explores the intricate role of the SNARE complex in the fusion of autophagosomes with lysosomes, a crucial step in autophagic flux. Disruptions in this fusion process, often resulting from aberrant SNARE complex function or impaired lysosomal acidification, contribute to the pathological accumulation of autophagosomes and lysosomes observed in AD.

Metabolic-Immune Suppression Mediated by the SIRT1-CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma.

Metabolic reprogramming of tumor cells dynamically reshapes the distribution of nutrients and signals in the tumor microenvironment (TME), affecting intercellular interactions and resulting in metabolic immune suppression. Increased glucose uptake and metabolism are characteristic of many tumors. Meanwhile, the progression of colorectal carcinoma (CRC) relies on lipid metabolism.

Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules.

Helicene-shaped molecules are compelling chemical structures with unique twisted helical chirality and remarkable properties. Although progress occurs in the catalytic asymmetric synthesis of helicene (-like) molecules, the enantioselective synthesis of multiple helicenes, especially four or higher helicity, is still challenging and has yet to be achieved. Herein, we report an organocatalytic [4 + 2] cycloadditions to achieve double S-shaped quadruple helicene-like molecules with high enantioselectivity (up to 96% e.

Collaborative integration of SERS and QCM sensing for label-free multi-component gas detection.

The effective qualitative and quantitative detection of mixed components of volatile organic compounds (VOCs) with similar molecular structures has always been a challenge and hotpoint in the research. A novel quartz-crystal microbalance (QCM) nanocomposite sensor integrated with a surface-enhanced Raman scattering (SERS) detection platform for multi-component gas analysis was proposed and fabricated in this paper. MIL-100 (Fe)/PAN composite fibers were developed on QCM via electrospinning of polyacrylonitrile (PAN) and hydrothermal synthesis, addressing the integration issues of MIL-100 particles in devices while maintaining high specific surface area.

Recent research progress on the biological functions, synthesis and applications of selenium nanoparticles.

Selenium is an essential trace element that is involved in a variety of complex biological processes and has a significant positive effect on the prevention and treatment of cardiovascular disease, inflammatory diseases, and cancer. Selenium in the body is mainly provided by daily meals. However, selenium has two sides, beneficial in moderation and harmful in excess.

MIFS: An adaptive multipath information fused self-supervised framework for drug discovery.

The production of expressive molecular representations with scarce labeled data is challenging for AI-driven drug discovery. Mainstream studies often follow a pipeline that pre-trains a specific molecular encoder and then fine-tunes it. However, the significant challenges of these methods are (1) neglecting the propagation of diverse information within molecules and (2) the absence of knowledge and chemical constraints in the pre-training strategy.

Performance Evaluation of University-Based Scientific Research Institutions With a Non-Independent Parallel System.

Performance management in university-based scientific research institutions is essential for driving reform, advancing education quality, and fostering innovation. However, current performance evaluation models often focus solely on research indicators, neglecting the critical interdependence between the education and research systems. This oversight leads to inefficiencies in resource allocation and an underestimation of overall institutional performance, particularly in universities with varying development levels.

Biomimetic Cerium-Assisted Supra-Carbon Dots Assembly for Reactive Oxygen Species-Activated Atherosclerosis Theranostic.

Theranostic applications in atherosclerosis plaque microenvironment-triggered nanoplatforms are significantly compromised by the complex synthesis procedure, non-specific distribution, and limited therapeutic function. Therefore, development of a facile and feasible method to construct a pathology-based stimuli-responsive nanoplatform with satisfactory theranostic performance remains a demanding and highly anticipated goal. Herein, a novel class of multifunctional supra-carbon dots (CDs), denoted as MM@Ce-CDs NPs, by a simple nanoassembly and a subsequent coating with macrophage membrane (MM), is developed for the targeted reactive oxygen species-trigged theranostic and positive regulation of the pathological plaque microenvironment in AS.

A Novel Array-Based Fluorescent Sensing Approach for the Identification and Quantification of Pesticides with High Sensitivity Based on Distinguishable Cross-response Algorithm.

The presence of excessive residues of pesticides poses a great threat to ecology and human health. Herein, a novel, low-cost, simple and precise quantification sensing platform was established for differentiating and monitoring four common pesticides in China. Particularly, the array-based ratio fluorescent sensor array detector (ARF-SAD) based on cross-reaction characteristics of porphyrins and other porphyrin derivative was successfully constructed and integrated into the platform.

Full-dimensional accurate potential energy surface and dynamics for the unimolecular isomerization reaction CH3NC ⇌ CH3CN.

The reaction CH3NC ⇌ CH3CN, a model reaction for the study of unimolecular isomerization, is important in astronomy and atmospheric chemistry and has long been studied by numerous experiments and theories. In this work, we report the first full-dimensional accurate potential energy surface (PES) of this reaction by the permutation invariant polynomial-neural network method based on 30 974 points, whose energies are calculated at the CCSD(T)-F12a/AVTZ level. Then, ring polymer molecular dynamics is used to derive the free energy barrier of the reaction at the experimental temperature range of 472.

Comparative chloroplast genome analysis of five widespread species ( L.) and development of molecular markers for their discrimination.

Background: Zanthoxylum L., an important genus in the Rutaceae family, has great edible and medical values. However, the high degree of morphological similarity among species and the lack of sufficient chloroplast (cp) genomic resources have greatly impeded germplasm identification and phylogenetic analyses of

Methods: Here we assembled cp genomes of five widespread species (, , , and ) in China as a case study, comparative analysis of these assembled cp genomes.

Erratum: Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy: Erratum.

[This corrects the article DOI: 10.7150/thno.22557.

Leech-Inspired Amphibious Soft Robot Driven by High-Voltage Triboelectricity.

Leech locomotion, characterized by alternating sucker attachment and body contraction provides high adaptability and stability on complex terrains. Herein, a leech-inspired triboelectric soft robot is proposed for the first time, capable of amphibious movement, climbing, and load-carrying crawling. A high-performance triboelectric bionic robot system is developed to drive and control electro-responsive soft robots.

Simultaneous measurement of liquid level and R.I. sensor using POF based on twisted structure.

In this paper, a dual-parameter liquid level and refractive index (R.I.) sensor is fabricated using three pieces of bare polymer optical fibers (POFs), which can independently and simultaneously sense the liquid level and R.