608 results match your criteria: "Chondromyxoid Fibroma"

Article Synopsis
  • Chondromyxoid fibromas (CMF) are rare benign bone tumors that can cause symptoms like pain or swelling, but may also be asymptomatic, making diagnosis difficult.
  • This report details a case of a 66-year-old woman whose tumor was initially misdiagnosed as a neuroma, later thought to be a low-grade osteosarcoma after surgery.
  • Ultimately, advanced testing confirmed it was a chondromyxoid fibroma, highlighting the need for thorough diagnostic approaches for accurate identification of these tumors.
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  • Osteochondroma is the most prevalent benign bone tumor that can cause pain and restricted movement, especially in children, and this report examines a specific case involving an 8-year-old boy with an intra-articular osteochondroma in his elbow.
  • The boy experienced persistent pain and limited motion in his elbow, leading to surgical intervention where a mass was successfully excised, and pathology confirmed the diagnosis.
  • The report emphasizes the necessity of surgical removal and histopathological examination to correctly diagnose osteochondroma and differentiate it from other potential intra-articular conditions.
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Article Synopsis
  • Chondromyxoid fibroma (CMF) is a rare and usually harmless bone tumor that mostly affects young adults, and figuring it out can be tricky.
  • Researchers looked at the GRM1 gene, which is linked to this tumor, to see if it has changes, fusions, or too much of its protein in CMF cases.
  • They found that most cases had extra GRM1 protein, and about 75% showed changes in the gene, but they didn't find any gene fusions, making it hard to use certain testing methods for diagnosing CMF.
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Surgical treatment of chondromyxoid fibroma of ribs is described. The diagnosis was verified after histological analysis. The patient underwent resection of multinodular tumor of anterolateral thoracic wall invading abdominal cavity via thoracoabdominal access.

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Chondromyxoid fibroma of the temporomandibular joint - a rare case.

Cranio

June 2024

Department of Oral and Maxillofacial Oncology & Surgery, School/Hospital of Stomatology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

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Chondromyxoid fibroma: A retrospective evaluation of 31 cases.

Jt Dis Relat Surg

April 2024

Sandıklı Devlet Hastanesi, Ortopedi ve Travmatoloji Kliniği, 03500 Sandıklı, Afyonkarahisar, Türkiye.

Objectives: This study aimed to review a 35-year experience with chondromyxoid fibroma at our institution.

Patients And Methods: The study retrospectively analyzed the records of 31 consecutive patients (17 males, 14 females; mean age: 30.5±15.

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Benign Non-Odontogenic Pathology in Children.

Oral Maxillofac Surg Clin North Am

August 2024

Department of Oral and Maxillofacial Surgery, University of Washington School of Dentistry, 1959 NE Pacific Street, B-307, Seattle, WA 98195, USA; Division of Plastic Surgery, Department of Surgery, University of Washington School of Medicine, 1959 Northeast Pacific Street, B-307, Seattle, WA 98195, USA; Craniofacial Center, Seattle Children's Hospital, 4800 Sand Point Way Northeast, Seattle, WA 98015, USA.

Article Synopsis
  • - The article discusses various benign non-odontogenic pathologies, focusing on bone-derived lesions like osteoma and osteoblastoma, covering their radiographic features, locations, and treatment options.
  • - It examines cartilage-derived lesions (such as chondroma) and fibroconnective tissue lesions, detailing their presentation and management strategies.
  • - Lastly, nerve-derived lesions like schwannoma and neurofibroma are explored, particularly their links to conditions like neurofibromatosis and recommended treatments.
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The clinical, radiological, and histopathological features of chondromyxoid fibroma can sometimes resemble those of other benign or malignant tumors. Recently, recurrent rearrangements have been identified in chondromyxoid fibroma, and GRM1 positivity by immunohistochemistry has emerged as a dependable surrogate marker for this molecular alteration. Phosphaturic mesenchymal tumor is a rare tumor that often exhibits overexpression of fibroblastic growth factor 23 (FGF23) through various mechanisms.

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Chondromyxoid fibroma is one of the rarest bone tumours, occurring most frequently in adult men in their second and third decades. It generally affects the metaphysis of long bones, particularly the femur and tibia. Diagnosis can pose differential challenges with various tumor types, particularly chondrosarcoma, requiring separate management.

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Introduction: Chondromyxoid fibroma (CMF) is a rare, benign bone tumor that occurs predominantly in the second and third decades of life, more frequently in males. Overexpression of GRM1 as a consequence of tumor-specific gene rearrangement of GRM1 has recently been reported as a useful immunohistochemical marker for histopathological diagnosis of CMF. However, the usefulness of GRM1 staining of cytology specimens has not yet been evaluated.

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Chondromyxoid fibroma (CMF) is a rarely documented benign osseous neoplasm, particularly with respect to its incidence in the lumbar spinal region. CMF predominantly manifests in vertebral bodies, exhibiting atypical emergence in ancillary anatomical sites. The present report describes, to the best of our knowledge, the second documented instance of CMF originating from the lumbar facet joint.

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Intracranial chondroid tumors are a heterogeneous group of neoplasms characterized by the presence of a cartilage matrix. These tumors exhibit overlapping clinical and histological features. Mutations in genes serve as important diagnostic markers of tumor type, particularly chondrosarcoma.

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Introduction: Medical advancements in musculoskeletal oncology has significantly reduced the mortality rate associated with limb-sparing surgery, making it comparable to amputation. The use of modular megaprosthesis for sarcoma treatment has now become a standard practice. However, these non-biological implants are not without their complications.

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A Case Report of Chondromyxoid Fibroma of the Nasal Cavity.

Indian J Otolaryngol Head Neck Surg

December 2023

Department of Otorhinolaryngology and Head and Neck Surgery, GMC, Rajindra Hospital, Patiala, India.

The chondromyxoid fibroma is a benign osseocartilaginous tumor histopathologically characterized by chondroid, fibrous, and myxoid tissues (Nazeer et al. in Skeltal Radiol 25:779-78, 1996). Its occurrence is quite rare, accounting for less than 0.

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Fusion of the Genes for Interferon Regulatory Factor 2 Binding Protein 2 () and Caudal Type Homeobox 1 () in a Chondrogenic Tumor.

In Vivo

November 2023

Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Background/aim: Chondrogenic tumors are benign, intermediate or malignant neoplasms showing cartilaginous differentiation. In 2012, we reported a mesenchymal chondrosarcoma carrying a t(1;5)(q42;q32) leading to an IRF2BP2::CDX1 fusion gene. Here, we report a second chondrogenic tumor carrying an IRF2BP2::CDX1 chimera.

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Long-term Outcome of Total Femur Replacement.

Malays Orthop J

July 2023

Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Introduction: Total femur replacement is an option instead of amputation for extensive bone tumour or after revision surgery with a massive bone loss. Over a long period of time the patients may need revision surgery, and this might affect the functional outcome. We reviewed all consecutive total femur replacements done for primary and revision surgery of primary bone tumours in our centre to evaluate the long-term functional outcome and survival.

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Recurrent chondromyxoid fibroma of the distal femur treated with percutaneous cryoablation.

Skeletal Radiol

December 2023

Russell H. Morgan Department of Radiology and Radiological Science, Division of Interventional Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Chondromyxoid fibroma is a rare, benign tumor of the bone with excellent prognosis but a high rate of recurrence. We report a patient presenting with pain and a history of chondromyxoid fibroma of the distal left femur previously treated with multiple prior curettage and bone graft procedures. Magnetic resonance imaging and histopathology indicated a recurrence of tumor.

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Utility of immunohistochemical expression of H3.3K36M and DOG1 in the diagnosis of chondroblastomas: An experience from a tertiary cancer referral center.

Ann Diagn Pathol

October 2023

Homi Bhabha National Institute (HBNI) University, Parel, Mumbai, Maharashtra, India; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment Research Education In Cancer (ACTREC), Khargar, Navi Mumbai, Maharashtra, India.

Despite its characteristic clinicopathological features, chondroblastoma may pose a diagnostic challenge, given its morphological spectrum, potential for subdiagnostic appearances in limited biopsy specimens, and its potential mimicry of other entities. Recently, a characteristic H3F3B mutation underlying most chondroblastomas was described, which led to the identification of H3.3K36M as the corresponding diagnostic immunohistochemical marker.

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Phosphaturic mesenchymal tumor: A chondromyxoid fibroma-like type.

J Dermatol

November 2023

Department of Clinical Pathology, Pathological Diagnosis Center, Fukuoka Tokushukai Hospital, Fukuoka, Japan.

Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm that causes tumor-induced osteomalasia (TIO) in most affected patients, usually through the production of fibroblast growth factor 23 (FGF23). This tumor is often misdiagnosed due to its relative rarity and its widely varied histomorphologic spectrum. Here we describe a case of a 78-year-old woman who presented with a left middle tumor without symptoms of TIO.

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Objective: This study aimed to examine the expression of Histone H3.3 glycine 34 to tryptophan (G34W) mutant protein in Giant Cell Tumor of Bone (GCTB).

Methods: This analytic observation research used a cross-sectional study design on 71 bone tumors.

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Chondromyxoid Fibroma of a Rib.

J Orthop Case Rep

January 2023

Department of Pathology, AIIMS, Bhubaneswar, Odisha, India.

Article Synopsis
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: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is an extremely rare subtype of osteosarcoma, its clinical data are scarce, and our understanding of it is far from sufficient. As it has few typical imaging manifestations, it is not uncommonly misdiagnosed clinically. Azygos vein thrombosis is also a rare entity, and there is a big controversy over treatments for it.

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