2,742 results match your criteria: "Chondrocalcinosis"
Coronary artery calcium and atherosclerotic cardiovascular disease risk scores in patients with calcium pyrophosphate deposition disease.
Rheumatology (Oxford)
December 2024
Brigham and Women's Hospital, Division of Cardiology, Boston, USA.
Objective: Calcium pyrophosphate deposition (CPPD) disease is associated with an increased risk for cardiovascular (CV) events. We examined the atherosclerotic burden by coronary artery calcium scores (Agatston score) and compared 10-year atherosclerotic CV (ASCVD) risk scores in patients with vs without chondrocalcinosis, a radiographic marker of CPPD.
Methods: We performed a cross-sectional analysis at an academic medical center, 1991-2022.
Development of a deep learning model for automated detection of calcium pyrophosphate deposition in hand radiographs.
Front Med (Lausanne)
October 2024
Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Article Synopsis
- CPPD disease is a significant cause of arthritis that can resemble other rheumatic conditions, making accurate diagnosis crucial.
- A deep-learning algorithm was developed and tested to automatically detect CPPD features in hand radiographs, focusing specifically on certain joint areas.
- The combined model for detecting CPPD showed strong performance metrics, with a mean AUROC of 0.86 and good sensitivity and specificity, while separate models for different joint areas had varying success rates.
[Calcium pyrophosphate deposition (CPPD) disease - more than just "pseudogout"].
Ther Umsch
September 2024
Universitätsklinik für Rheumatologie und Immunologie Freiburgstrasse, Anna-Seiler Haus, Stock J 3010 Bern.
Article Synopsis
- Calcium pyrophosphate deposition (CPPD) disease, often called "pseudogout," can be mistaken for gout but is a distinct condition in rheumatology.
- Unlike gout, CPPD cannot be cured and requires symptomatic treatment instead.
- The text reviews the pathophysiology, diagnosis, and current and emerging therapeutic approaches for managing CPPD.
[Imaging in crystal arthropathies].
Ther Umsch
September 2024
Institut für Diagnostische und Interventionelle Radiologie, Universitätsspital Zürich.
Article Synopsis
- * Advancements in radiological techniques, both with and without ionizing radiation, have improved the diagnosis and management of these conditions over recent decades.
- * The article reviews current evidence on traditional methods (X-ray, ultrasound, MRI) alongside newer techniques (dual-energy CT, photon-counting CT), highlighting their respective benefits and drawbacks based on latest professional guidelines.
Prevalence of chondrocalcinosis and calcium pyrophosphate deposition disease in a cohort of adult patients with low alkaline phosphatase levels and a positive versus negative genetic study.
JBMR Plus
November 2024
Rheumatology Unit, La Paz University Hospital, Paseo de la Castellana, 261, 28046 Madrid, Spain.
Article Synopsis
- A study estimated how common chondrocalcinosis and CPPD are in patients with low alkaline phosphatase (ALP) levels and a genetic marker for hypophosphatasia (HPP), compared to those without the genetic marker.
- Results showed that chondrocalcinosis was significantly more prevalent in the genetically positive (+GT) group (21.4%) than in the negative (-GT) group (5.6%).
- The findings suggest that chondrocalcinosis is common in HPP patients, and it's important to consider genetic factors when diagnosing related conditions.
Arthroscopic Resection of Acromioclavicular Joint Cysts and Distal Clavicle: A Report of 3 Cases.
JBJS Case Connect
October 2024
Sports Medicine Institute, Hospital for Special Surgery, New York, New York.
Article Synopsis
- Three patients with cysts in their acromioclavicular joints, caused by rotator cuff problems, were treated with a specific surgical technique.
- The procedure involved arthroscopic cyst decompression and removing part of the clavicle, which successfully eliminated the cysts with low chances of them coming back.
- The study suggests that this surgical approach is a better option than repeatedly draining the cysts or performing traditional open surgery.
New Developments in Imaging in Crystalline Arthritis.
Rheum Dis Clin North Am
November 2024
Department of Medicine, Allergy/Immunology & Rheumatology Division, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA. Electronic address:
Article Synopsis
- * Traditional diagnosis relied on joint aspiration and microscopy, but imaging techniques are now preferred and can often suffice.
- * Recommended imaging methods include ultrasound, dual-energy CT scans, and regular X-rays, which can help locate inflammation and identify crystal deposits effectively.
Efficacy and safety of 10 mg versus 30 mg of oral prednisolone for acute CPP crystal arthritis: findings of a randomized controlled trial.
Clin Rheumatol
December 2024
Rheumatology Division, Department of Internal Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Article Synopsis
- A study was conducted to compare the effectiveness and safety of 10-mg and 30-mg daily doses of prednisolone for treating acute calcium pyrophosphate (CPP) crystal arthritis.
- In this trial, 79 patients received either dose for 7 days, with the primary focus on symptom resolution time and secondary outcomes including recurrence rates and adverse events.
- Results showed no significant differences between the two doses in terms of symptom resolution time, recurrence rates, or safety, indicating that both doses are equally effective for managing acute CPP crystal arthritis.
Adalimumab treatment of resistant chondrocalcinosis.
Reumatol Clin (Engl Ed)
October 2024
Ege University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey.
Article Synopsis
- In this article, the authors discuss a case of chondrocalcinosis that didn't respond to traditional treatments but showed improvement with 40mg of adalimumab, an injection.
- This is notable because it's the first time adalimumab has been reported to work effectively for severe calcium pyrophosphate dihydrate (CPDD) conditions.
- The findings suggest that anti-TNF therapies like adalimumab could be a viable second-line treatment for cases of calcium pyrophosphate crystal disease (CPPD).
The acetabularization index: a novel measure of acromial bone loss prior to reverse shoulder arthroplasty.
Eur J Orthop Surg Traumatol
December 2024
Department of Trauma Surgery, Lörrach District Hospital, Spitalstraße 25, 79539, Lörrach, , Baden-Württemberg, Germany.
Article Synopsis
- The study investigates acromial stress fractures related to reverse shoulder arthroplasty (RSA), focusing on a new measure called the acetabularization index (AI) to assess preoperative acromial bone loss in patients with cuff tear arthropathy (CTA).
- Researchers measured several parameters from preoperative radiographs and 2D CT scans of 33 patients, finding significant differences in the AI values and a negative correlation between AI and acromiohumeral interval (AHI), indicating that as AI increases, AHI tends to decrease.
- The conclusion highlights that AI is a reliable and measurable tool for evaluating acromial bone loss, which could help surgeons in planning RSA
Activation of osmo-sensitive LRRC8 anion channels in macrophages is important for micro-crystallin joint inflammation.
Nat Commun
September 2024
Université Paris Cité, INSERM UMR-1132, Bioscar, Hôpital Lariboisière, AP-HP, Paris, France.
Article Synopsis
- Monosodium urate (MSU) and calcium pyrophosphate (CPP) micro-crystals lead to inflammation in conditions like gout and chondrocalcinosis by activating macrophages, which release cytokines like IL-1β.
- The maturation of IL-1β is driven by the NLRP3 inflammasome, which gets activated in response to these crystals.
- This activation is dependent on the LRRC8 anion channels, as they help regulate cell volume and trigger ATP release, resulting in IL-1β maturation and inflammation, demonstrating their important role in joint inflammation from crystal deposits.
Differential diagnosis of pseudogout of the lumbar spine.
BMJ Case Rep
September 2024
Orthopaedic Surgery, Mahidol University Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
Article Synopsis
- A case report describes a rare occurrence of pseudogout in a 55-year-old man, who presented with severe low-back pain and fever, initially misdiagnosed as a spinal infection.
- Imaging showed lumbar spondylosis, but an MRI revealed a cystic lesion at the lumbar joint, leading to further testing that confirmed calcium pyrophosphate crystals.
- Successful treatment with oral colchicine provided rapid pain relief, illustrating the need for thorough investigations to accurately diagnose rare conditions and avoid unnecessary treatments.
[Familial Hypocalciuric Hypercalcemia Type 1 Likely Secondary to a New Inactivating Mutation of CASR].
G Ital Nefrol
August 2024
U.O. Nefrologia e Dialisi, Ospedale "M. Bufalini", Cesena, Italia.
Article Synopsis
- * There are three types of FHH, with type 1 being the most common, linked to a mutation in the CASR gene, while types 2 and 3 are associated with mutations in the GNA11 and AP2S1 genes, respectively.
- * Identifying FHH is crucial for distinguishing it from primary hyperparathyroidism, which occurs more frequently; misdiagnosis could lead to unnecessary surgeries, especially since genetic testing can clarify the condition.
Acute Neck Pain from Crowned Dens Syndrome: A Case Report and Clinical Insights.
Am J Case Rep
August 2024
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Article Synopsis
- Crowned dens syndrome (CDS) is a rare condition where calcium pyrophosphate crystals form a calcified 'crown' on the second cervical vertebra, leading to neck pain and symptoms similar to meningitis.
- A case report details a 62-year-old man who experienced severe headaches and neck pain, ultimately diagnosed with CDS through CT scan, and responded well to treatment with NSAIDs.
- The report emphasizes the need for increased awareness of CDS among clinicians to reduce misdiagnosis, especially in older patients with new neck pain and a history of pseudogout, and calls for further research on its diagnosis and treatment.
Crowned Dens Syndrome-Pseudogout of the Neck.
Acute Med
August 2024
Department of Emergency Medicine, The York Hospital, York, UK.
Article Synopsis
- A patient experienced neck pain along with episodes of fever.
- The case highlights a rare presentation of pseudogout affecting the neck area.
- Pseudogout is a type of arthritis caused by crystal deposition in the joints, leading to inflammation.
Prevalence and classification of meniscal calcifications in the human knee.
Osteoarthritis Cartilage
November 2024
Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. Electronic address:
Article Synopsis
- The study aimed to explore meniscal calcifications in individuals with and without knee osteoarthritis (OA), focusing on two types: basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP).
- The researchers analyzed 82 meniscal samples from 41 subjects, comparing those with OA (who had knee replacements) to deceased donors without OA, using histological methods and Raman spectroscopy for detailed analysis.
- Results showed that all OA participants had some calcifications, primarily BCP, while CPP was more common in donor samples, indicating that BCP may play a key role in the OA process deserving further study.
Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions.
Curr Rheumatol Rep
November 2024
University of Cyprus Medical School, Nicosia, Cyprus.
Article Synopsis
- The review focuses on CPPD (Calcium pyrophosphate deposition disease), outlining its medical conditions and risk factors, particularly in older adults.
- Recent studies highlight a connection between CPPD and systemic conditions, notably an increased risk of cardiovascular diseases along with associations to other metabolic and endocrine disorders.
- There is a need for further research to understand the mechanisms behind these associations and to create targeted therapies for better patient outcomes.
Efficacy of a single ultrasound-guided injection of high molecular weight hyaluronic acid combined with collagen tripeptide in patients with knee osteoarthritis and chondrocalcinosis.
Front Med (Lausanne)
July 2024
Department of Rheumatology, University of Medicine and Pharmacy Craiova, Craiova, Romania.
Article Synopsis
- - The study investigates the effectiveness of combining high molecular weight hyaluronic acid (HMWHA) and collagen tripeptide (CTP) to treat patients with both osteoarthritis (OA) and calcium pyrophosphate deposition (CPPD), conditions that worsen inflammation and cartilage damage.
- - A retrospective analysis monitored 29 patients receiving ultrasound-guided injections, measuring pain and joint function over 6 months using NRS and WOMAC scores, revealing significant improvement in both assessments.
- - Results indicated that 79% of patients experienced meaningful pain reduction (NRS) and 83% showed functional improvement (WOMAC), with the most notable benefits observed by the 6-month evaluation.
Calcium pyrophosphate deposition disease.
Lancet Rheumatol
November 2024
Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Article Synopsis
- - Calcium pyrophosphate deposition disease (CPPD) occurs when CPP crystals build up in joints, triggering inflammation and arthritis, particularly in older individuals over 60, and is linked to cartilage deterioration and osteoarthritis.
- - Common risk factors for CPPD include aging, past joint injuries, and certain metabolic conditions or genetic factors. Diagnosis relies on detecting CPP crystals in joint fluid and imaging techniques like X-rays and ultrasound.
- - Current treatment focuses on managing inflammation since there’s no cure for dissolving CPP crystals; options include prednisone for acute arthritis, low-dose colchicine, and potential use of biologics for stubborn cases.
Calcium Pyrophosphate Crystal Formation and Deposition: Where Do we Stand and What Does the Future hold?
Curr Rheumatol Rep
October 2024
Rheumatology Department, IRCCS Galeazzi - Sant'Ambrogio Hospital, Milan, Italy.
Article Synopsis
- The review discusses the long-understood but poorly defined pathogenesis of calcium pyrophosphate deposition (CPPD), highlighting the need for deeper research.
- Recent advancements include the 2023 ACR/EULAR classification criteria for CPPD and new imaging techniques, although basic research is lagging behind.
- Emerging methods like Raman spectroscopy and omics sciences may pave the way for better understanding and management of CPPD as it becomes more common in an aging population.
Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort.
Arthritis Rheumatol
December 2024
University of Nottingham, Nottingham, United Kingdom.
Article Synopsis
- The study aimed to analyze the disease, demographic, and imaging characteristics linked to different types of calcium pyrophosphate deposition (CPPD) disease, focusing on recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS).
- Researchers utilized data from an international cohort of 618 individuals to investigate the phenotypic traits of each type of CPPD and performed multivariable logistic regression to assess associations between risk factors and inflammatory phenotypes.
- Key findings indicated that longer disease duration correlated with recurrent acute arthritis, while chronic arthritis was linked to specific joint issues and less associated with metabolic risks, and CDS was more common in males with greater joint involvement. *
Current Role of Conventional Radiology in Rheumatology.
Radiol Clin North Am
September 2024
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, L'Aquila 67100, Italy.
Article Synopsis
- - Understanding radiological findings in rheumatological diseases is crucial for making accurate diagnoses, as X-rays are widely available, affordable, and can reveal subtle bone changes.
- - Various scoring systems help clinicians assess joint damage seen on X-rays, highlighting the importance of proper interpretation.
- - The review will focus on common X-ray findings in key areas like the hands, hips, and spine, which can assist in diagnosing different rheumatological conditions.
Hypercalcemia and Postoperative Joint Symptoms Following Joint Replacement for Osteoarthritis.
J Surg Res
September 2024
Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Article Synopsis
- The study examines the impact of preoperative high calcium levels (hypercalcemia) on the outcomes of total hip and knee replacements in patients, particularly in the context of primary hyperparathyroidism (PHPT).
- A retrospective review analyzed 495 patients, comparing those with elevated calcium levels to those with normal levels, finding no significant differences in postoperative recovery or complications.
- The findings suggest hypercalcemic patients do not have worse outcomes after surgery; however, a majority did not have their parathyroid hormone levels checked, indicating a need for further investigation into PHPT in these patients.
Synovial Membrane Is a Major Producer of Extracellular Inorganic Pyrophosphate in Response to Hypoxia.
Pharmaceuticals (Basel)
June 2024
Université de Lorraine, CNRS, IMoPA, F-54000 Nancy, France.
Article Synopsis
- Calcium pyrophosphate dehydrate (CPPD) crystals in synovial fluid are linked to conditions like articular chondrocalcinosis and osteoarthritis, with their formation influenced by inorganic pyrophosphate (ePPi) levels.
- Transient hypoxia during inflammation, especially in the synovial membrane, can enhance ePPi production, primarily through the increase of the transporters Ank and ENPP1 induced by transforming growth factor (TGF)-β1.
- The study found that TGF-β1 and hypoxic conditions collaborate to boost ePPi production in synovial fibroblasts, with Ank being the dominant factor, and that hypoxia primarily activates a specific regulatory path involving hypoxia-induced