9 results match your criteria: "Chobanian and Avedisian School of Medicine at Boston University[Affiliation]"
Electronic Adolescent Substance Use Screening: Focus on Implementation is Needed.
Am J Prev Med
October 2024
Hassenfeld Child Health Innovation Institute, Providence, Rhode Island; Department of Health Services, Policy and Practice, Brown University, Providence, Rhode Island.
Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury-induced physiological and behavioral maladaptations.
Pain
December 2024
Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Preclinical and clinical work has demonstrated altered plasticity and activity in the nucleus accumbens (NAc) under chronic pain states, highlighting critical therapeutic avenues for the management of chronic pain conditions. In this study, we demonstrate that myocyte enhancer factor 2C (MEF2C), a master regulator of neuronal activity and plasticity, is repressed in NAc neurons after prolonged spared nerve injury (SNI). Viral-mediated overexpression of Mef2c in NAc neurons partially ameliorated sensory hypersensitivity and emotional behaviors in mice with SNI, while also altering transcriptional pathways associated with synaptic signaling.
View Article and Find Full Text PDFMetabolic Disease and The Risk of Post-COVID Conditions: A Retrospective Cohort Study.
medRxiv
March 2024
Department of Global Health, Boston University School of Public Health, Boston, MA, USA.
Objective: To examine the influence of having a baseline metabolic disorder (diabetes, hypertension, and/or obesity) on the risk of developing new clinical sequelae potentially related to SARS-CoV-2 in a large sample of commercially insured adults in the US.
Design Setting And Participants: Deidentified data were collected from the IBM/Watson MarketScan Commercial Claims and Encounters (CCAE) Databases and Medicare Supplemental and Coordination of Benefits (MDCR) Databases from 2019 to 2021. A total of 839,344 adults aged 18 and above with continuous enrollment in the health plan were included in the analyses.
Risk Stratification to Reduce Excess Mortality in Early Psychosis.
JAMA Netw Open
March 2024
Department of Psychiatry, Chobanian and Avedisian School of Medicine at Boston University, Boston, Massachusetts.
C3d-Targeted factor H inhibits tissue complement in disease models and reduces glomerular injury without affecting circulating complement.
Mol Ther
April 2024
Q32 Bio, Waltham, MA 02451, USA. Electronic address:
Article Synopsis
- Complement-mediated diseases can be treated using specific inhibitors, but traditional systemic approaches may increase infection risk and have limited efficacy due to high levels of complement in circulation.
- Researchers developed a new therapy, an antibody fusion protein (C3d-mAb-2fH), that targets complement activity directly in affected tissues rather than systemic circulation, improving localized treatment.
- Experiments show that this approach effectively inhibits complement in tissue and has demonstrated positive results in models for skin and kidney diseases without causing systemic side effects.
Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model.
Int J Mol Sci
February 2024
Leni and Peter W. May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Chronic painful intervertebral disc (IVD) degeneration (i.e., discogenic pain) is a major source of global disability needing improved knowledge on multiple-tissue interactions and how they progress in order improve treatment strategies.
View Article and Find Full Text PDFThe Dorsal Raphe as a Regulator of Emotion and Reward: Beyond Pain.
Biol Psychiatry
December 2023
Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedisian School of Medicine at Boston University, Boston, Massachusetts. Electronic address:
Uncovering Biased Signaling of Atypical Antipsychotics at Dopamine D Receptors in the Prefrontal Cortex.
Biol Psychiatry
October 2023
Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedisian School of Medicine at Boston University, Boston, Massachusetts. Electronic address:
Otolaryngology and the Pregnant Patient.
JAMA Otolaryngol Head Neck Surg
October 2023
Department of Otolaryngology-Head and Neck Surgery, Boston Medical Center, Chobanian and Avedisian School of Medicine at Boston University, Boston, Massachusetts.
Importance: Pregnancy may result in physiologic and pathologic changes in the head and neck. Otolaryngologists may need to intervene medically or surgically with pregnant patients. Careful consideration of risks to both the gravid patient and the developing fetus is vital.
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