[Down-regulated expression of c-Jun in peripheral blood mononuclear cells of patients with severe secondary pulmonary tuberculosis].

Objective: To compare the expression of c-Jun in severe versus mild secondary pulmonary tuberculosis (TB) and understand the relationship of the c-Jun expression with the inflammation and immune injury of severe secondary TB patients.

Methods: Differentially expressed genes were screened in patients with severe TB, the ones with mild TB and healthy controls using Affymetrix human gene expression chips. Bioinformatic analysis was performed on the results of the gene chip screening.