846 results match your criteria: "Chinese and Western Medicine Hospital[Affiliation]"
Cell membrane-coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within a cell membrane-derived coating, these nanoparticles combine the advantages of synthetic nanoparticles and natural cell membranes. This review provides a comprehensive overview of the recent advancements in utilizing CMNPs as effective drug delivery vehicles for cancer therapy.
View Article and Find Full Text PDFJ Ethnopharmacol
December 2024
Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China. Electronic address:
Ethnopharmacological Relevance: Delayed tissue-type plasminogen activator (t-PA) thrombolysis, which has a restrictive therapeutic time window within 4.5 h following ischemic stroke (IS), increases the risk of hemorrhagic transformation (HT) and subsequent neurotoxicity. Studies have shown that the NLRP3 inflammasome activation reversely regulated by the PGC-1α leads to microglial polarization and pyroptosis to cause damage to nerve cells and the blood-brain barrier.
View Article and Find Full Text PDFExpert Opin Drug Saf
December 2024
Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Fabry disease (FD), an X-linked lysosomal disorder, is marked by a lack of alpha-galactosidase A (α-Gal A). Agalsidase beta, a recombinant form of α-Gal A, is fundamental to enzyme replacement therapy for FD but requires close monitoring for adverse events (AEs).
Research Design And Methods: This study retrospectively analyzed the Food and Drug Administration Adverse Event Reporting System (FAERS) database for agalsidase beta-related AEs.
World J Psychiatry
December 2024
Department of Rehabilitation, Taizhou Integrated Traditional Chinese and West Medicine Hospital, Taizhou 317500, Zhejiang Province, China.
Background: The treatment of adolescent patients with anxiety, depression and insomnia is challenging, and there is no ideal treatment method.
Aim: To evaluate the clinical efficacy of Wuling capsule combined with sertraline in the treatment of adolescent anxiety, depression and insomnia.
Methods: Eighty adolescent patients with anxiety, depression with insomnia who were admitted to our hospital from April 1, 2022 to March 30, 2024.
Turk J Gastroenterol
December 2024
Department of Traditional Chinese Medicine, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Esophageal cancer is a highly prevalent gastrointestinal tumor in China, resulting in a significant number of deaths annually. In this paper, we investigated the regulatory role and therapeutic potential of aberrant ST7-AS1 expression in esophageal cancer. The presence of ST7-AS1 in 125 esophageal cancer tissues was identified through RT-qPCR assays.
View Article and Find Full Text PDFAm J Transl Res
November 2024
Department of Pediatrics, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital Hangzhou 310003, Zhejiang, China.
Eosinophilic gastroenteritis (EGE) is an inflammatory disease characterized by a significant increase in eosinophils. EGE itself is rare, and cases with clinical manifestations of hemorrhagic ascites are even rarer, which undoubtedly increases the risk of misdiagnosis. Given this, this study reports a rare case of pediatric EGE presenting with paroxysmal abdominal pain without apparent cause, accompanied by acute tonsillitis and mesenteric lymphadenitis, suggesting a possible intestinal infection.
View Article and Find Full Text PDFBiochim Biophys Acta Rev Cancer
December 2024
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023. China; Jiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Cancer represents a substantial threat to human health and mortality, necessitating the development of novel pharmacological agents with innovative mechanisms of action. Consequently, extensive research has been directed toward discovering new anticancer compounds derived from natural sources, including plants, microbes, and marine organisms. This review offers a comprehensive analysis of natural anticancer agents that are either currently undergoing clinical trials or have been integrated into clinical practice.
View Article and Find Full Text PDFCurr Med Sci
December 2024
Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective: The trigger receptor expressed on myeloid cells-2 (TREM2) pathway in myeloid cells is a key disease-inducing immune signaling hub that is essential for detecting tissue damage and limiting its pathological spread. However, the role and potential mechanisms of TREM2 in wound repair remain unclear. The purpose of this study was to determine the role and mechanism of TREM2 in skin wound healing in mice.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
Department of Cardiology, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, China.
Background: Stable angina pectoris, resulting from coronary artery atherosclerosis, significantly affects quality of life and carries a high risk of cardiovascular events. Despite modern therapies, managing this condition remains challenging. Traditional Chinese medicine (TCM) views it as a syndrome of heart meridian obstruction by phlegm and blood stasis, necessitating improved circulation and phlegm resolution.
View Article and Find Full Text PDFMol Med Rep
February 2025
Department of Geriatric Medicine, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the western blotting data shown in Fig. 4B on p. 4988 had already appeared in an article written by different authors at different research institutes that had already been published.
View Article and Find Full Text PDFPak J Med Sci
December 2024
Jinjuan Xu Department of General Geriatrics, Linping District Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou City, Zhejiang Province 311100, P.R. China.
Objective: To explore the hepatoprotective effect of diammonium glycyrrhizinate (DG) in the treatment of pulmonary tuberculosis.
Methods: This is a retrospective analysis of clinical data of 113 patients with pulmonary tuberculosis, admitted to The First People's Hospital of Linping District from March 2020 to December 2022. Among them, 55 patients who received conventional anti-tuberculosis treatment (2HRZE/4HR) alone were assigned to the Routine group, while 58 patients who received anti-tuberculosis treatment combined with DG treatment were assigned to the DG group.
Surg Laparosc Endosc Percutan Tech
December 2024
Department of General Surgery, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou, China.
Objective: This study aims to assess the effectiveness of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the endoscopic resection of colonic polyps and investigate the factors influencing polyp recurrence.
Methods: A total of 174 patients with colorectal polyps admitted to the Gastroenterology Department during the same period were included in this prospective randomized controlled study. The patients were randomly allocated to the EMR group and ESD group (72 cases in each group) using a random number table.
Int J Biol Macromol
December 2024
Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China. Electronic address:
Bacterial infections during wound healing often cause inflammation, which delays the healing process. Therefore, innovative wound dressings are urgently needed to inhibit bacterial infections and promote healing. This study proposes an Ag-functionalized chitosan hydrogel dressing, formed via a Schiff-base reaction between alkynyl Ag substituted chitosan (Ag-CS) and octafunctionalized polyhedral oligomeric silsesquioxane with benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO), to address the issue of bacterial infection in wounds.
View Article and Find Full Text PDFAm J Cardiol
December 2024
Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. Electronic address:
There are limited data about the clinical benefits and harm of oral anticoagulants (OACs) for stroke prevention in patients with atrial fibrillation (AF) and chronic kidney disease using CKD-EPI creatinine equation for glomerular filtration rate (GFR) estimation in nuanced GFR stratification. We conducted a retrospective study in 12 centers in China and included 9,510 patients with AF. We grouped patients into the following estimated GFR (eGFR) categories: ≥60 (n = 7,616), 45 to 59 (n = 1,139), 30 to 44 (n = 474), and <30 (n = 281) ml/min/1.
View Article and Find Full Text PDFPain Physician
November 2024
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA.
Background: Occipital neuralgia manifests as pain in the cutaneous distribution of occipital nerves, with the greater occipital nerve stemming from the C2 spinal nerve and the lesser occipital nerve originating from the C2 and C3 spinal nerves. While pulsed radiofrequency ablation of the C2 dorsal root ganglion (DRG) is an effective treatment for refractory occipital neuralgia, accessing the C2 DRG remains a clinical challenge even under fluoroscopic guidance.
Objective: We aimed to develop an ultrasonographic method for quickly and accurately accessing the C2 DRG.
Sci Rep
November 2024
Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, 430022, China.
In the general population, there is limited evidence for the associations between hand eczema (HE) and lifestyle factors, and between the severity of HE and quality of life. This study aimed to estimate the risk factors for the incidence of HE in the general population and the risk factors for the severity of HE. A cross-sectional questionnaire was administered to 121 HE patients in a hospital from December 2018 to December 2019 in Wuhan.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2024
Department of Orthopedics, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
This study explores the correlation between knee osteoarthritis and musculoskeletal ultrasound manifestations based on changes in traditional Chinese medicine (TCM) syndrome types. The study enrolled 104 patients with knee osteoarthritis admitted to the Gansu Provincial Hospital of TCM between January 2019 and January 2021. According to the principle of syndrome differentiation and treatment in TCM, the patients were divided into wind-cold-damp obstruction (n = 17), damp-heat accumulation (n = 22), qi-stagnation and blood stasis (n = 31), and liver and kidney deficiency (n = 34) types.
View Article and Find Full Text PDFLin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
December 2024
Eur Heart J
November 2024
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
Front Physiol
October 2024
Department of Liver Disease, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, China.
Background: The early detection and intervention of liver fibrosis (LF) in patients with chronic liver disease is critical to their management. The accuracy of serum Mac-2 binding protein glycosylation isomer (M2BPGi) in the diagnosis of LF remains controversial. This study aimed to comprehensively assess the value of serum M2BPGi in diagnosing LF.
View Article and Find Full Text PDFPak J Med Sci
November 2024
Liping Wu Department of General Geriatrics, Linping District Integrated Traditional, Chinese and Western Medicine Hospital, Hangzhou, Zhejiang Province 311100, P.R. China.
Objective: To compare the therapeutic efficacy of tenofovir disoproxil fumarate (TDF) and entecavir (ETV) in patients with chronic Hepatitis-B (CHB).
Methods: This retrospective study included 110 patients with CHB who received treatment at The First People's Hospital of Linping District, Hangzhou from January 2021 to January 2023. Clinical data of the patients were reviewed and the patients were classified according to the treatment received: TDF group (n=53, patients received TDF treatment) and ETV group (n=57, patients received ETV treatment).
J Thorac Dis
October 2024
Department of Respiration, Lanzhou University Second Hospital, Lanzhou, China.
Background: Numerous guidelines pertaining to adult diagnostic flexible bronchoscopes (FBs) have been published by Chinese and international organizations, but, to date, there has been no report on their quality. This study aimed to evaluate the quality of existing guidelines for adult diagnostic FB examination using the Appraisal of Guidelines for Research & Evaluation Instrument II (AGREE II), and its main recommendations were summarized to provide a reference for clinical professionals.
Methods: A search was conducted for guidelines related to adult diagnostic FB published in China and internationally.
J Ethnopharmacol
February 2025
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China; College of Traditional Chinese Medicine, Hebei University, Baoding, 071000, China. Electronic address:
Ethnopharmacological Relevance: Epilepsy (EP) is one of the most prevalent chronic neurological disorders in children, characterised by a prolonged course and a propensity for recurrence. Banxia Baizhu Tianma Decoction (BBTD), a traditional Chinese medicine formula, is commonly employed in the clinical management of EP and has demonstrated satisfactory therapeutic effects.
Aim Of The Study: This study aimed to evaluate the anti-epileptic effects of BBTD and to explore its molecular mechanisms.
Photodiagnosis Photodyn Ther
December 2024
Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan 430022, Hubei, PR China. Electronic address:
Vitiligo is an acquired chronic depigmentary skin disorder which results from the destruction of melanocytes. The clinical characteristic of vitiligo is the development of white macules due to the loss of functioning melanocytes in the skin or hair. Vitiligo in the genital area brings about a serious psychological impact on individuals.
View Article and Find Full Text PDFAm J Transl Res
October 2024
Department of Pharmacy, Integrated Traditional Chinese and Western Medicine Hospital of Wenzhou Wenzhou 325000, Zhejiang, China.
Objective: To investigate the protective effect of Peimine (PM) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and the underlying mechanisms.
Methods: KM mice were randomly divided into five groups: Control, LPS, Peimine low-dose (PM-L, 0.1 mg/kg), medium-dose (PM-M, 1 mg/kg), and high-dose (PM-H, 10 mg/kg) groups.