A retrospective analysis of 338 surgically treated pituitary adenomas.

Objective: To summarize the clinical characteristics, pituitary function assessment, postoperative pathological features, and postoperative recurrence of surgically treated pituitary adenomas (PAs).

Methods: We retrospectively reviewed the data of 338 patients (169 women; average age: 50.01 ± 12.

Functional analysis and modification of anti-lipopolysaccharide factor (ALF) from the freshwater crab Sinopotamon henanense and preparation of a novel ShALF6-2 K-AgNPs complex.

Overuse of antibiotics has led to the emergence of drug-resistant bacteria and environmental problems. Antimicrobial peptides (AMPs) and silver nanoparticles (AgNPs) can potentially replace antibiotics. Therefore, it is possible to create composite nanostructures with synergistic bactericidal properties by combining AgNPs and AMPs.

Difference in movement coordination and variability during Five-Repetition Sit-to-Stand between people with and without Chronic Low back pain.

Chronic low back pain (CLBP) affects people's activities of daily living, including sitting down and standing up. Movement pattern analyses during five-repetition sit-to-stand (5RSTS) may allow CLBP status differentiation. 44 CLBP and 22 asymptomatic participants performed 5RSTS in this study, with their trunk and lower limb movements recorded using 3-dimensional motion capture system.

When low-light meets flares: Towards Synchronous Flare Removal and Brightness Enhancement.

Low-light image enhancement (LLIE) aims to improve the visibility and illumination of low-light images. However, real-world low-light images are usually accompanied with flares caused by light sources, which make it difficult to discern the content of dark images. In this case, current LLIE and nighttime flare removal methods face challenges in handling these flared low-light images effectively: (1) Flares in dark images will disturb the content of images and cause uneven lighting, potentially resulting in overexposure or chromatic aberration; (2) the slight noise in low-light images may be amplified during the process of enhancement, leading to speckle noise and blur in the enhanced images; (3) the nighttime flare removal methods usually ignore the detailed information in dark regions, which may cause inaccurate representation.

Effects of ketogenic and low-carbohydrate diets on the body composition of adults with overweight or obesity: A systematic review and meta-analysis of randomised controlled trials.

Background And Aims: More than one-third of individuals are overweight and obese in the world. Their risks of chronic health conditions are increased, which places additional burden on their family, caregivers, and healthcare system. Dietary modification is widely used for overweight and obese individuals.

Needs Assessment to Guide the Development of a Pediatric Survivorship Program to Promote the Physical and Psychological Well-being of Children After Cancer Treatment.

Background: Studies have provided insights into the major challenges and needs of young children who survive cancer. Many such challenges are related to a lack of support during the patient's transition back to normal life. Survivorship programs are designed to help survivors cope with potential late effects of treatment and to provide psychosocial support.

Unraveling Mechanisms of Genetic Risks in Metabolic Dysfunction-Associated Steatotic Liver Diseases: A Pathway to Precision Medicine.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health problem, affecting ∼1 billion people. This condition is well established to have a heritable component with strong familial clustering. With the extraordinary breakthroughs in genetic research techniques coupled with their application to large-scale biobanks, the field of genetics in MASLD has expanded rapidly.

Long COVID and gut microbiome: insights into pathogenesis and therapeutics.

Post-acute coronavirus disease 2019 syndrome (PACS), following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 (COVID-19), is typically characterized by long-term debilitating symptoms affecting multiple organs and systems. Unfortunately, there is currently a lack of effective treatment strategies. Altered gut microbiome has been proposed as one of the plausible mechanisms involved in the pathogenesis of PACS; extensive studies have emerged to bridge the gap between the persistent symptoms and the dysbiosis of gut microbiome.

Gender Disparities in Pandemic-Related Strains, Digital Coping Strategies, and Protective Mechanisms Among Rural-to-Urban Migrant Working Adolescents in China.

The COVID-19 pandemic placed significant strains on daily life, particularly affecting vulnerable groups such as rural-to-urban young migrant workers. Based on General Strain Theory (GST), these pandemic-related strains lead to delinquent copings, including excessive Internet use. However, the association between pandemic-related challenges faced by migrant youth and their digital copings has yet to be investigated.

A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition.

Emotion recognition is an advanced technology for understanding human behavior and psychological states, with extensive applications for mental health monitoring, human-computer interaction, and affective computing. Based on electroencephalography (EEG), the biomedical signals naturally generated by the brain, this work proposes a resource-efficient multi-entropy fusion method for classifying emotional states. First, Discrete Wavelet Transform (DWT) is applied to extract five brain rhythms, i.

Reconstruction of Multiple Strings of Constant Weight from Prefix-Suffix Compositions.

Motivated by studies of data retrieval in polymer-based storage systems, we consider the problem of reconstructing a multiset of binary strings that have the same length and the same weight from the compositions of their prefixes and suffixes of every possible length. We provide necessary and sufficient conditions for which unique reconstruction up to the reversal of the strings is possible. Additionally, we present two algorithms for reconstructing strings from the compositions of prefixes and suffixes of constant-length constant-weight strings.

Updates on Information Theory and Network Coding.

Around the year 2000, network coding introduced the concept that coding can replace the basic packet forwarding operation used in traditional network communication systems [...

The pattern of cytokine profile in children received extracorporeal blood purification.

We reported the cytokine profile in children <18 years old who received extracorporeal blood purification (EBP) for sepsis, rhabdomyolysis, hyperbilirubinaemia, acute respiratory distress syndrome or cytokine storm, and determined the factors affecting the cytokine removal kinetics. Plasma levels of 38 types of cytokine/chemokine were measured at pre-EBP, 12 and 24 h after initiating EBP. Altogether there were 11 eligible episodes admitted between April 2021 and December 2023.

scMMAE: masked cross-attention network for single-cell multimodal omics fusion to enhance unimodal omics.

Multimodal omics provide deeper insight into the biological processes and cellular functions, especially transcriptomics and proteomics. Computational methods have been proposed for the integration of single-cell multimodal omics of transcriptomics and proteomics. However, existing methods primarily concentrate on the alignment of different omics, overlooking the unique information inherent in each omics type.

Exploring the toxicology, socio-ecological impacts and biodegradation of microplastics in Africa: Potentials for resource conservation.

Achieving upcycling and circularity in the microplastic economy predominantly depends on collecting and sorting plastic waste from the source to the end-user for resource conservation. Microplastics, whether from packaging or non-packaging materials, pose a significant environmental challenge as they are often not prioritized for collection or recycling initiatives. The presence of additives impedes the quality of plastic recyclates and the persistence of microplastics as shredded resultants remain a threat to the aquatic and terrestrial ecosystem and its biodiversity.

Development and pilot testing of a nurse-led common-sense model of self-regulation-based heart failure self-care program.

Background: Self-care practices among people with heart failure (HF) remain suboptimal. Nurse-led self-care interventions hold promise in managing this condition. The Common-Sense Model (CSM) of Self-Regulation is a widely adopted theoretical framework that promotes behavior change and improves disease prognosis among patients.

Remodeling the Proinflammatory Microenvironment in Osteoarthritis through Interleukin-1 Beta Tailored Exosome Cargo for Inflammatory Regulation and Cartilage Regeneration.

Osteoarthritis (OA) presents a significant therapeutic challenge, with few options for preserving joint cartilage and repairing associated tissue damage. Inflammation is a pivotal factor in OA-induced cartilage deterioration and synovial inflammation. Recently, exosomes derived from human umbilical cord mesenchymal stem cells (HucMSCs) have gained recognition as a promising noncellular therapeutic modality, but their use is hindered by the challenge of harvesting a sufficient number of exosomes with effective therapeutic efficacy.

Precision Oncology: A Global Perspective on Implementation and Policy Development.

Despite the acknowledged merits of precision oncology (PO) and its increasing global implementation, its full potential for advancing care and prevention remains unrealized. The benefits are currently accessible to only limited patient segments because of multifaceted barriers. Successful implementation hinges on various factors-scientific complexities not limited to technical, clinical, regulatory, economic, administrative, and health care policy-related challenges.

Dating the bacterial tree of life based on ancient symbiosis.

Obtaining a timescale for bacterial evolution is crucial to understand early life evolution but is difficult owing to the scarcity of bacterial fossils. Here, we introduce multiple new time constraints to calibrate bacterial evolution based on ancient symbiosis. This idea is implemented using a bacterial tree constructed with genes found in the mitochondrial lineages phylogenetically embedded within Proteobacteria.

Enhancing drug solubility through competitive adsorption on silica nanosurfaces with ultrahigh silanol densities.

We develop a technology based on competitive adsorption between drug molecules and water, specifically designed to address the critical issue of poor drug solubility. By specially engineering silica nanosurfaces with ultrahigh densities of silanol, we significantly enhance their affinity for both drug molecules and water, with a notably greater increase in water affinity. Such surfaces can effectively adsorb a variety of drug molecules under dry conditions.

Funeral support services for socio-economically deprived bereaved people in Hong Kong: An exploratory study of their effectiveness.

This study aimed to explore the effectiveness of funeral support services for socio-economically deprived bereaved people in Hong Kong. Via a questionnaire, service users were asked to report their psychosocial status in different domains before and after the services. A quasi-experimental design was also used to compare service users with non-service users in different psychosocial domains after the funerals had taken place.

Multi-center real-world data-driven web calculator for predicting outcomes in IDH-mutant gliomas: Integrating molecular subtypes and treatment modalities.

Background: Isocitrate dehydrogenase (IDH)-mutant gliomas generally have a better prognosis than IDH-wild-type glioblastomas, and the extent of resection significantly impacts prognosis. However, there is a lack of integrated tools for predicting outcomes based on molecular subtypes and treatment modalities. This study aimed to identify factors influencing gross total resection (GTR) rates and to develop a clinical prognostic tool for IDH-mutant gliomas.

Asymmetric Intraocular Pressure Changes in Dominant and Contralateral Eyes: The Dark Room Prone Provocative Test.

Purpose: To evaluate changes in intraocular pressure (IOP) in dominant and contralateral eyes following the dark room prone provocative test (DRPPT) in the study subjects with shallow anterior chamber.

Methods: This was a prospective, single-center, non-randomized controlled trial of 43 subjects (86 eyes) with shallow anterior chamber. The dominant eye was identified using the card-hole method.