3 results match your criteria: "Chinese PLA General HospitalBeijing 100853[Affiliation]"

Inner ear structure of miniature pigs measured by multi-planar reconstruction techniques.

Am J Transl Res

March 2018

Department of Otolayngology, Head & Neck Surgery, Institute of Otolaryngology of PLA, Chinese PLA General HospitalBeijing 100853, P. R. China.

To study the structures of the scala vestibuli and tympani of miniature pigs in order to evaluate the feasibility of using miniature pigs as the animal model for cochlear implant. The temporal bones of three miniature pigs with normal hearing were scanned by micro-CT. With the aid of the Mimics software, we reconstructed the 3D structure of inner ear basing on the serial images of the miniature pig, and obtained dimensions of the scala vestibuli and tympani with multi-planar reconstruction (MPR) technique.

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Article Synopsis
  • - Age-related hearing loss (ARHL), or presbyacusis, results mainly from degeneration in sensory cells of the auditory system and is linked to increased reactive oxygen species (ROS) and inflammatory responses in the aging cochlea.
  • - Research using various methods found elevated levels of activated proteins and inflammatory markers (like Caspase-1 and interleukins) in the inner ears of older mice compared to younger ones.
  • - The study suggests that inflammation from inflammasome activation in the cochlea could play a significant role in the development of ARHL, indicating a potential target for addressing age-related hearing loss.
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Miniature pigs: a large animal model of cochlear implantation.

Am J Transl Res

December 2016

Department of Otolaryngology, Head & Neck Surgery, Institute of Otolaryngology of PLA, Chinese PLA General Hospital Beijing 100853, China.

The objective of this paper was to investigate the suitability of the miniature pig as a large animal model of cochlear implantation (CI). Micro-CT scanning and three-dimensional reconstructions of the inner ear were completed in six animals. Photographs of the procedures and measurements of the inner ear were made.

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