CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines.

Background: Cancer stem cells (CSCs) have been considered as a potential therapeutic target for cervical carcinoma. CD 276 is a well-known immune check point molecular, but its relationship with cervical CSCs was still unclear.

Methods: HeLa cell lines were obtained as cervical carcinoma model.

In vivo biological safety evaluation of an iron-based bioresorbable drug-eluting stent.

Bioresorbable stents (BRS) are investigated and designed to revascularize occluded arteries. The iron-based bioresorbable stent is a promising device in interventional therapies, although it's corrosion and bioresorption rate remain challenging. In this work, we introduced a novel nitrided iron coronary stent (IBS) with enhanced degradation rate compared with pure iron stent.

Quantifying the degradation of degradable implants and bone formation in the femoral condyle using micro-CT 3D reconstruction.

Degradation limits the application of magnesium alloys, and evaluation methods for non-traumatic quantification of implant degradation and bone formation are imperfect. In the present study, a micro-arc-oxidized AZ31 magnesium alloy was used to evaluate the degradation of implants and new bone formation in 60 male New Zealand white rabbits. Degradation was monitored by weighing the implants prior to and following implantation, and by performing micro-computed tomography (CT) scans and histological analysis after 1, 4, 12, 24, 36, and 48 weeks of implantation.

Chronic Systemic Toxicity Study of Copper Intrauterine Devices in Female Wistar Rats.

BACKGROUND The aim of this study was to evaluate the chronic systemic and local toxicity of a copper intrauterine device in a rat model. MATERIAL AND METHODS Cu-IUD fragments were inserted into the uterine horns of female Wistar rats for 26 weeks (equivalent 15.42-17.

Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography.

The calcification initiation and progression of bioprosthetic heart valve were investigated in a rat model by enhanced micro-computed tomography, together with histologic study and scanning electron microscope analysis. The implantation data at early stage showed apparent dendritic patterns in the radiographic images for the glutaraldehyde-treated bovine pericardium and this dendritic pattern was verified to be associated with the vessel distribution in the tissue. Histologic study and scanning electron microscope analysis both indicated that the calcium deposits in the pericardium vessels regions were more grievous than those scattered in the collagen fibers in the first two weeks after implantation.

Evaluation of a bioactive bone-inducing material consisting of collagen scaffolds and collagen-binding bone morphogenetic protein 2.

Bioactive bone-inducing material (BBIM) is a collagen-based scaffold composed of demineralized bone matrix and collagen-binding domain bone morphogenetic protein 2 (BMP-2). BBIM is regarded as a promising bone-inducing scaffold to repair bone defects. In this work, we evaluated the biocompatibility and osteogenecity of BBIM.