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[The genetic characteristics analysis of fusion gene of 13 strains measles viruses in China].

Zhongguo Yi Miao He Mian Yi

February 2009

State Key Laboratory for Molecuar Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Preverntion, Beijing 100050, China.

Objective: To study genetic characteristics of fusion gene (F gene) of H1 genotype of wild measles virus circulated in China from 1999 to 2003.

Method: 13 H1 genotype representative strains including 8 subgenotype H1a strains and 5 subgenotype H1b strains isolated in mainland China during 1999-2003 were selected. Entire F gene were amplified by reverse transcript-polymerase chain reaction and sequenced, then they were compared with the nucleotide acid sequences of Chinese measles vaccine strains and the representative strains of A, D3, D6, D7 and E genotypes from other countries.

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