Radiation knowledge and anxiety levels among residents proximity to the world's first AP1000 nuclear power unit.

Objective: Assess the level of radiation-related knowledge (RRK) and nuclear energy-related knowledge (NERK) among residents near the Sanmen Nuclear Power Plant, the first project adopted the Advanced Passive Pressurized Water Reactor (AP1000) technology.

Methods: In this study, respondents were selected using stratified multi-stage random sampling for residents aged 18 years and above living within 30 kilometers of the Sanmen Nuclear Power Station. Respondents were surveyed face-to-face by investigators who received standardized training.

The graded heat-health risk forecast and early warning with full-season coverage across China: a predicting model development and evaluation study.

Background: Due to global climate change, high temperature and heatwaves have become critical issues that pose a threat to human health. An effective early warning system is essential to mitigate the health risks associated with high temperature and heatwaves. However, most of the current heatwave early warning systems are not adequately developed based on the heat-health risk model, and the health impact of hot weather has not been well managed in most countries.

T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots.

Although antibody escape is observed in emerging severe acute respiratory syndrome coronavirus 2 variants, T cell escape, especially after the global circulation of BA.2.86/JN.

Relationship between meteorological factors and the incidence of severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis.

Objective: Although meteorological factors are connected with severe fever with thrombocytopenia syndrome (SFTS) incidence, available findings have been inconsistent. This study was performed to systematically evaluate the correlation between meteorological factors and SFTS incidence.

Methods: We performed a thorough literature search in PubMed, Web of Science, Embase, Cochrane Library, and Chinese databases from databases initiatives to November 30, 2024.

Original article: Efficacy and safety of single-dose suraxavir marboxil tablet in the treatment of acute uncomplicated influenza in adults: a multi-center, randomized, double-blind, placebo-controlled phase 2 clinical trial.

Objectives: To evaluate the therapeutic effect of suraxavir marboxil (GP681, abbreviated as suraxavir) in adults with uncomplicated influenza.

Methods: We conducted a multi-center randomized, double-blind, placebo-controlled phase 2 trial in 18 Chinese centers. Participants had to be aged 18-65 years with positive influenza test, presenting with at least one influenza systemic and respiratory symptoms in at least moderate severity within 48 hours of onset.

Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study.

Personal care products (PCPs) are ubiquitously present in the environment, and the associated health risks have been increasingly concerned worldwide. However, knowledge regarding exposure assessments of older adults to these chemicals and their health risks remains largely limited. In the present study, five repeated surveys involving 76 healthy older adults in Jinan, Shandong Province, were performed to quantify urinary exposure levels of 14 chemicals in PCPs.

Associations of First-Year Low-Level Viremia with Subsequent Viral Non-Suppression in People Living with HIV on Antiretroviral Therapy - Dehong Dai and Jingpo Autonomous Prefecture, Yunnan Province, China, 2008-2021.

What Is Already Known About This Topic?: Human immunodeficiency virus (HIV) low-level viremia (LLV) during antiretroviral therapy (ART) occurs frequently in Dehong Dai and Jingpo Autonomous Prefecture, Yunnan Province.

What Is Added By This Report?: Among people living with HIV who achieved virological success [viral load (VL) <1,000 copies/mL] after initiating ART in Dehong Prefecture, Southwest China, 17.6% experienced first-year LLV of 50-999 copies/mL First-year LLV emerged as an independent risk factor for subsequent viral non-suppression compared with participants maintaining first-year VL <50 copies/mL.

Characteristics and Predictors of Interprovincial Migration Following HIV Diagnosis Among Men Who Have Sex with Men - China, 2016-2022.

What Is Already Known About This Topic?: Men who have sex with men (MSM) are highly vulnerable to human immunodeficiency virus (HIV) infection and demonstrate significant mobility patterns. Understanding post-diagnosis migration patterns among HIV-positive MSM is crucial for targeted case management, yet comprehensive data from China remains limited.

What Is Added By This Report?: Among 204,394 HIV-positive MSM, 20,117 (9.

Synergizing Digital and Physical Approaches: Experience Summary of the HIV PrEP Promotion Project.

China's human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS) prevention and control efforts have entered a new stage, necessitating the exploration of more effective intervention strategies. HIV pre-exposure prophylaxis (PrEP) is a proven method to prevent HIV infection, but its promotion in China faces challenges such as low public acceptance and inadequate service capacity. To further promote PrEP, the "HIV PrEP Model Exploration Project" was launched, exploring three PrEP service models: PrEP clinics, Digital services and physical testing, and PrEP self-service vending machines.

Pretreatment HIV Drug Resistance to Integrase Strand Transfer Inhibitors Among Newly Diagnosed HIV Individuals - China, 2018-2023.

Introduction: The widespread adoption of integrase strand transfer inhibitors (INSTIs) has led to the emergence of INSTI-associated drug-resistance mutations. This cross-sectional study conducted a comprehensive national survey to investigate the prevalence of pretreatment drug resistance (PDR) to INSTIs among newly diagnosed human immunodeficiency virus (HIV) individuals in China.

Methods: The study enrolled 10,654 individuals from 31 provincial-level administrative divisions between 2018 and 2023.

The negative impacts of bisphenols on thyroid function in adults with bisphenol A exposure level exceeding the tolerable daily intake.

In 2023, European Food Safety Authority (EFSA) published a re-evaluation of the safety of bisphenol A (BPA), establishing the new tolerable daily intake (TDI) as 0.2 ng/kg·bw/day with a 20,000-fold reduction compared to 2015, which regained public concern about the impact of bisphenols (BPs) on human health. In order to explore the health risk to thyroid function of BPs, in this study, we assessed the internal exposure levels of BPs and the relationships between urinary BPs and thyroid function in general adults.

Clinical Performance of MAGLUMI Diagnostic Tests for the Automated Detection of Dengue Virus.

Aims: The screening and diagnosis of dengue virus infection play a crucial role in controlling the epidemic of dengue fever, highlighting the urgent need for a highly sensitive, simple, and rapid laboratory testing method. This study aims to assess the clinical performance of MAGLUMI Denv NS1 in detecting dengue virus NS1 antigen.

Methods: A retrospective study was conducted to assess the sensitivity and specificity of MAGLUMI Denv NS1 using residual samples.

Overweight and Obese Children Aged 6-17 Years in China Had Lower Level of Hydration Status: A Cross-Sectional Study.

Purpose: The aims of this study were to explore the differences in total body water and hydration status among Chinese children aged 6-17 years.

Methods: A cross-sectional study was implemented among children aged 6-17 years in China. The total body water (TBW), intracellular water (ICW), and extracellular water (ECW) were determined by bioelectrical impedance analysis (BIA).

Association Between Protein-Rich Foods, Nutritional Supplements, and Age of Natural Menopause and Its Symptoms.

Objective: To investigate the relationship between protein-rich foods, various nutritional supplements, and age of natural menopause and its symptoms.

Methods: This study was a large-scale cross-sectional survey. A multi-stage stratified random sampling method was used to select a sample of 52,347 residents aged 35-60 years from 26 districts/counties across 13 cities in 12 provinces in China.

The Inhibitory Effects of NCT503 and Exogenous Serine on High-Selenium Induced Insulin Resistance in Mice.

Objective: This study aims to identify whether the development of insulin resistance (IR) induced by high selenium (Se) is related to serine deficiency via the inhibition of the de novo serine synthesis pathway (SSP) by the administrations of 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (NCT503) or exogenous serine in mice.

Method: forty-eight male C57BL/6J mice were randomly divided into four groups: adequate-Se (0.1 mgSe/kg), high-Se (0.

Weight Status and Myopia in Children and Adolescents: A Nationwide Cross-Sectional Study of China.

Background/objectives: The prevalence of both myopia and obesity is increasing among children and adolescents around the world. We aimed to examine the association between weight status and myopia in Chinese children and adolescents.

Methods: The analysis included 35,108 participants aged 6-17 from a nationwide cross-sectional survey.

Sand and dust storms: a growing global health threat calls for international health studies to support policy action.

Sand and dust storms increasingly threaten global environmental and public health. To date, 150 countries are directly affected, with more than 100 classified as non-dust source regions. With climate change, these storms are expected to become more frequent and severe.

Study on exhaled volatile organic compounds identifying cognitive fatigue induced by N-back task in healthy young adults.

Cognitive fatigue in specific occupations may present a risk to personal safety. The study aimed to explore the characteristic volatile organic compounds (VOCs) in exhaled breath in response to cognitive fatigue, to provide a scientific basis for the non-invasive exhaled breath diagnostic techniques for cognitive fatigue assessing. Thirty healthy young adults were recruited and assigned to complete two 1.

Immunogenicity of HIV-1 mRNA and VLP mRNA Vaccines in Mice.

Background: The development of a protective vaccine is critical for conclusively ending the human immunodeficiency virus (HIV) epidemic.

Methods: We constructed nucleotide-modified mRNA vaccines expressing HIV-1 Env and Gag proteins. Env-gag virus-like particles (VLPs) were generated through co-transfection with env and gag mRNA vaccines.

The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences.

Background: Polypeptide vaccines have the potential to improve immune responses by targeting conserved and weakly immunogenic regions in antigens. This study aimed to identify and evaluate the efficacy of a novel influenza universal vaccine candidate consisting of multiple polypeptides derived from highly conserved regions of influenza virus proteins hemagglutinin (HA), neuraminidase (NA), and matrix protein 2 (M2).

Methods: Immunoinformatics tools were used to screen conserved epitopes from different influenza virus subtypes (H1N1, H3N2, H5N1, H7N9, H9N2, and IBV).

Attitudes Toward General Vaccination Mediate the Association Between Influenza Vaccination History and Pneumococcal Vaccination Intention Among Older Adults in China.

Influenza and pneumococcal vaccinations play a crucial role in disease prevention among older adults and are recommended to older adults aged 60 years and over in China, but the vaccination rates are suboptimal. Behavioral spillover indicates that a change in one behavior may lead to changes in other related behaviors. Based on the Behavioral Spillover Theory, this study aimed to investigate the association between influenza vaccination history and pneumococcal vaccination intention, as well as the mediating role of negative attitudes toward general vaccination among older adults in China.

Echinococcosis: From Parasite-Host Interaction to Rapid Detection.

Echinococcosis is one of the most serious and life-threatening parasitic zoonoses worldwide caused by the larvae of the genus [...

determination of protective antibody thresholds for SARS-CoV-2 variants using mouse models.

Neutralizing antibody titers have been shown to correlate with immune protection against COVID-19 and can be used to estimate vaccine effectiveness. Numerous studies have explored the relationship between neutralizing antibodies and protection. However, there remains a lack of quantitative data directly assessing the minimum effective protective neutralizing antibody titer in .