Regional antimicrobial resistance gene flow among the One Health sectors in China.

Background: Antimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.

Results: In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples.

Rapid climate action is needed: comparing heat vs. COVID-19-related mortality.

The impacts of climate change on human health are often underestimated or perceived to be in a distant future. Here, we present the projected impacts of climate change in the context of COVID-19, a recent human health catastrophe. We compared projected heat mortality with COVID-19 deaths in 38 cities worldwide and found that in half of these cities, heat-related deaths could exceed annual COVID-19 deaths in less than ten years (at + 3.

Lysoglycerophospholipid metabolism alterations associated with ambient fine particulate matter exposure: Insights into the pro-atherosclerotic effects.

The biological pathways connecting ambient fine particulate matter (PM)-induced initial adverse effects to the development of atherosclerotic cardiovascular diseases are not fully understood. We hypothesize that lysoglycerophospholipids (LysoGPLs) are pivotal mediators of atherosclerosis induced by exposure to PM. This study investigated the changes of LysoGPLs in response to PM exposure and the mediation role of LysoGPLs in the pro-atherosclerotic effects of PM exposure.

HIV Pre-Exposure Prophylaxis Cascade Stages Among Men Who Have Sex With Men With Sexually Transmitted Infections in China: Multicenter Cross-Sectional Survey Study.

Background: There is limited literature available regarding the knowledge and use of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) with sexually transmitted infections (STIs).

Objective: This study's objective was to explore the HIV PrEP cascade stages (knowledge, willingness to use, and use) among MSM with STIs in China, in order to promote the implementation of PrEP in this population.

Methods: A cross-sectional study was conducted using a respondent-driven sampling method in 19 cities in China, from January to August 2022.

Inter-city movement pattern of notifiable infectious diseases in China: a social network analysis.

Background: Co-existence of efficient transportation networks and geographic imbalance of medical resources greatly facilitated inter-city migration of patients of infectious diseases in China.

Methods: To characterize the migration patterns of major notifiable infectious diseases (NIDs) during 2016-2020 in China, we collected migratory cases, who had illness onset in one city but were diagnosed and reported in another, from the National Notifiable Infectious Disease Reporting System, and conducted a nationwide network analysis of migratory cases of major NIDs at the city (prefecture) level.

Findings: In total, 2,674,892 migratory cases of NIDs were reported in China during 2016-2020.

Metallo-supramolecular complexes enantioselectively target monkeypox virus RNA G-quadruplex and bolster immune responses against MPXV.

The Mpox virus (MPXV) has emerged as a formidable orthopoxvirus, posing an immense challenge to global public health. An understanding of the regulatory mechanisms of MPXV infection, replication and immune evasion will benefit the development of novel antiviral strategies. Despite the involvement of G-quadruplexes (G4s) in modulating the infection and replication processes of multiple viruses, their roles in the MPXV life cycle remain largely unknown.

Epidemiology of breast cancer in Chinese women from 1990 to 2021: a systematic analysis and comparison with the global burden.

Background: Breast cancer is a major global public health concern and a major cause of cancer-related mortality. In 2020, 8.3% of the total breast cancer deaths worldwide were reported from China, which highlighted the need to understand the epidemiological trends of breast cancer within the country.

The mechanism-specific injury mortality burden associated with heatwave in China in a warming world.

Numerous studies have investigated the impact of heatwaves on non-accidental mortality, yet the association and burden of heatwaves on mechanism-specific injury mortality remain underexplored. This study collected 257,267 injury-related fatalities and corresponding daily maximum temperatures (DMT) across seven Chinese provinces from 2013 to 2023. A heatwave was characterized by two or more successive days where the DMT surpassed its 92.

Exposure to tobacco advertisements or promotions and smoking susceptibility among adolescents in China from 2013-14 to 2021: findings from the China National Youth Tobacco Survey.

Background: Tobacco advertisements or promotions (TAPs) can increase smoking susceptibility, especially among adolescents.China has made great progress in reducing TAPs, but has not yet achieved a total ban.This study estimated exposure to TAPs and smoking susceptibility and their changes from 2013-14 to 2021 among Chinese adolescents and examined their association.

The Burden of Multiple Myeloma in China: Trends from 1990 to 2021 and Forecasts for 2050.

This study updates the disease burden of multiple myeloma (MM) in thirty-three provincial administrative units in China from 1990 to 2021 and forecast the disease burden for 2050. Data from the 2021 Global Burden of Disease (GBD) database was used for analysis. In 2021, there were an estimated 17,250 new MM cases and 12,984 deaths in China.

The potential of urinary miR-200c-3p as a biomarker of fluorosis in rats.

Fluorine is a strong oxidizing element and excessive intake can have harmful effects, particularly on the body's calcified tissues. Recent studies have demonstrated a link between miRNA and fluorosis. This study aimed to evaluate the time-dose-effect relationship of miR-200c-3p in plasma, urine and cartilage of rats with drinking water fluorosis, and to explore its potential as a biomarker.

Effective prediction of organosilicon molecular structures and risks in aquatic environment with machine learning.

Until now, mass spectrometry databases lack molecular information of most organosilicon oligomers, and risk models needing accurate molecular descriptors are unavailable for these emerging contaminants with thousands of monomers. To address this issue, based on molecular/fragment ions and relative abundance from GC-Orbitrap-MS, this study developed appropriate classification (accuracies = 0.750-0.

High-alcohol-producing Klebsiella pneumoniae aggravates lung injury by affecting neutrophils and the airway epithelium.

We have previously reported that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut can cause endo-alcoholic fatty liver disease. Here, we discover that 91.2% of Kpn isolates from pulmonary disease samples also produce excess ethanol, which may be associated with respiratory disease severity.

[Interpretation of Ergonomic guidelines for the prevention of work-related musculoskeletal disorders part 6: Wooden furniture manufacturing work (T/WSJD 14.6-2024)].

"Ergonomic guidelines for the prevention of work-related musculoskeletal disorders Part 6: Wooden furniture manufacturing work" provides comprehensive preventive measures for China's wooden furniture manufacturing industry, covering scope of application, hazard factors identification, potential affected areas, intervention measures and effect evaluation. Through systematic ergonomics strategies, the guide emphasizes improving the working environment, cultivating employee awareness, eliminating hazard factors, and providing practical guidance for creating a healthy and safe working environment. This article interprets and analyzes the standard project background, formulation process, basic basis and main content to help relevant practitioners more fully understand and implement the ergonomics scheme proposed by the standard, and provide enterprises with scientific and accurate technical support.

[Visualization analysis of research progress on work-related musculoskeletal disorders in domestic and international].

To study aims to examine the current state and future trajectory of research on work-related musculoskeletal disorders (WMSDs) both domestically and internationally. In February 2024, Using CiteSpace software and bibliometrics, a bibliometric analysis and knowledge map study were conducted on the Web of Science core journal collection and 3144 related documents from CNKI as of December 31, 2023. This study included a total of 3144 articles (723 in Chinese and 2421 in English).

[Structural equation analysis and modeling of wrist WMSDs and its adverse ergonomic factors].

To investigate the relationships and impacts between various occupational ergonomic hazards and hand and wrist fatigue, as well as work-related musculoskeletal disorders (WMSDs) of the hand and wrist, and to propose targeted preventive and intervention measures for adverse occupational ergonomic factors causing WMSDs of the hand and wrist. From 2018 to December 2023, a nationwide epidemiologic survey study of wrist WMSDs was conducted using the Chinese version of the electronic questionnaire system for musculoskeletal disorders.A total of 88, 609 valid questionnaires were collected.

[Research on RULA, REBA and OWAS based exposure risk assessment methods].

To accurately identify occupational health and safety hazards in different industries with distinct characteristics, a comprehensive occupational ergonomics assessment scale was developed by integrating the Rapid Upper Limb Assessment (RULA) evaluation framework, the Rapid Entire Body Assessment (REBA) and the Ovako Working Posture Analysing System (OWAS) . Between May 2023 and May 2024, based on the proportional reasoning method and segmented function method, the algorithm logic of RULA and REBA was aligned, and the evaluation rules for the revision content of the innovation scale were inferred using the method of proportion reasoning. Twenty postures were randomly selected for correlation verification.

[Effects of muscle fatigue on urine metabolites in automobile manufacturing workers based on untargeted metabolomics].

To investigate the changes of metabolites in urine of automobile manufacturing workers with muscle fatigue using metabolomics technology, and to explore potential biomarkers and disrupted metabolic pathways. In July 2022, urine samples were collected from 35 male workers in a certain automobile manufacturing industry before and after muscle fatigue, and metabolite analysis was conducted. Subsequently, multivariate statistical analysis was used for data processing to screen differential metabolites.

[Study on the epidemiological characteristics of work-related musculoskeletal disorders among 29 industries or occupational groups in China].

To analyze the distribution characteristics of work-related musculoskeletal disorders (WMSDs) among the occupational population in China's key industries during the period from 2018 to 2023, and to provide data support for the formulation of targeted prevention strategies. Between January 1, 2018, and December 31, 2023, a cross-sectional epidemiological survey and a retrospective investigation were conducted in seven geographical regions of North China, East China, Central China, South China, Southwest China, Northwest China, and Northeast China, using a combination of epidemiological cross-sectional and retrospective surveys. The industries were stratified according to the degree of closeness to WMSDs, the size of the occupational population, and the importance of the national economy, and then cluster sampling was conducted according to the size of the enterprises (large, medium, and small) within each stratum.

Tris(2-chloroethyl) Phosphate Leads to Unbalanced Circulating Erythrocyte in Mice by Activating both Medullary and Extramedullary Erythropoiesis.

Tris(2-chloroethyl) phosphate (TCEP), a prevalent organophosphorus flame retardant, has been identified in various environmental matrices and human blood samples, provoking alarm regarding its hematological toxicity, a subject that has not been thoroughly investigated. Red blood cells (RBCs), or erythrocytes, are the predominant cell type in peripheral blood and are crucial for the maintenance of physiological health. This investigation employed oral gavage to examine the effects of TCEP exposure on erythrocyte counts in mice and to clarify the underlying mechanisms.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.