A Pilot Study of Radiomics Models Combining Multi-Probe and Multi-Modality Images of Ga-NOTA-PRGD2 and F-FDG PET/CT for Differentiating Benign and Malignant Pulmonary Space-Occupying Lesions.

Background: This is a pilot study of radiomics based on Ga-NOTA-PRGD2 [NOTA-PEG4-E[c(RGDfK)]2)] and F-FDG PET/CT to (i) evaluate the diagnostic efficacy of radiomics features of Ga-NOTA-PRGD2 PET in the differential diagnosis of benign and malignant pulmonary space-occupying lesions and (ii) compare the diagnostic efficacy of multi-modality and multi-probe images.

Methods: We utilized a dataset of 48 patients who participated in Ga-NOTA-PRGD2 PET/CT and F-FDG PET/CT clinical trials to extract image features and evaluate their diagnostic efficacy in the differentiation of benign and malignant lesions by the Mann-Whitney U test. After feature selection with sequential forward selection, random forest models were developed with tenfold cross-validation.

Erythroid differentiation denucleation factors (EDDFs) function as intrinsic, post-erythropoietin regulators for mammalian erythroid terminal differentiation.

Regulatory factors other than erythropoietin (Epo) dependence, that control mammalian erythroid terminal differentiation, are currently uncertain. Here we report the existence of erythroid differentiation factors in erythroid cytoplasm. Purification of these factors from cultured Friend virus anaemia (FVA)-infected mouse splenic erythroblasts was carried out using isoelectrophoresis and high performance of liquid chromatography techniques.