1 results match your criteria: "ChinaKey Laboratory of Modern Chinese Medicines (China Pharmaceutical University)[Affiliation]"
Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway.
Br J Pharmacol
March 2012
Department of Pharmacognosy, College of Pharmacy, 3rd Military Medical University, Chongqing, ChinaGraduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KentuckyDepartment of Hematology, Southwest Hospital, 3rd Military Medical University, Chongqing, ChinaKey Laboratory of Modern Chinese Medicines (China Pharmaceutical University), Ministry of Education, Nanjing, China.
Background And Purpose: Ursolic acid (UA) has been extensively used as an anti-leukaemic agent in traditional Chinese medicine. In the present study, we investigated the ability of UA to induce apoptosis in human leukaemia cells in relation to its effects on caspase activation, Mcl-1 down-regulation and perturbations in stress-induced signalling pathways such as PKB and JNK.
Experimental Approach: Leukaemia cells were treated with UA after which apoptosis, caspase activation, PKB and JNK signalling pathways were evaluated.