[Survey of cachexia in digestive system cancer patients and its impact on clinical outcomes].

Objective: To investigate cachexia in hospitalized patients with digestive system cancer and evaluate its impact on clinical outcomes.

Methods: By analyzing the clinical data of 5118 hospitalized patients with digestive system cancer in Zhongshan Hospital of Fudan University from January 2012 to December 2013, cachexia was investigated and clinical outcomes between cachexia patients and non-cachexia patients was compared.

Results: The total cachexia rate of hospitalized patients with digestive system cancer was 15.

[Nutritional support in the treatment of patients with gastrointestinal cancer].

Patients with gastrointestinal(GI) tract neoplasms usually suffer from malnutrition, which is associated with increased morbidity and mortality, reduction of treatment efficacy, increased risk of therapy-associated side-effects, increased length of hospital stay, and reduced quality of life. Proposing an adaptive nutritional support at each step of a multidisciplinary treatment approach for GI cancer is essential.

[Clinical control study of laparoscopic versus open surgery for rectal cancer].

Objective: To evaluate the safety and short-term outcomes of laparoscopic-assisted surgery for rectal cancer by comparing the efficacy of laparoscopy and open surgery.

Methods: Clinical data of patients with rectal cancer treated by laparoscopy or open surgery in Zhongshan Hospital from April 2011 to June 2012 were analyzed retrospectively, and the clinical outcomes between the two groups were compared.

Results: Ninety-six rectal cancer patients undergoing laparoscopic surgery(LS) were enrolled.

The effect of HIF-1α on glucose metabolism, growth and apoptosis of pancreatic cancerous cells.

Objectives: The aim of this study is to explore the possible role of HIF-1α in glucose metabolism, proliferation and apoptosis of pancreatic cancerous cells.

Method: The pancreatic cancerous BxPC-3 cells were cultured in normoxia or hypoxia (3% O2), respectively. Cell proliferation was determined by MTT assay, apoptosis was determined by Annexin V/PI staining.

[Assessment of energy expenditure and body composition in cancer patients].

Objective: To demonstrate the changes of resting energy expenditure (REE), substrate metabolism and body composition in cancer patients.

Methods: From September 2004 to March 2008, REE, carbohydrate oxidation (CO) and fat oxidation (FO) in 936 cancer patients and 840 control subjects were measured by indirect calorimetry. Bioelectrical impedance appliance was applied to assess intracellular fluid, extracellular fluid, fat mass (FM) and fat free mass (FFM) in the two groups.