3 results match your criteria: "China. wangliangxing@wzhospital.cn.[Affiliation]"
Emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae from 2014 - 2021 in Central and Eastern China: a molecular, biological, and epidemiological study.
BMC Microbiol
November 2024
Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Article Synopsis
- - The study investigates two types of Klebsiella pneumoniae: carbapenem-resistant hypervirulent (CR-hvKP) and hypervirulent carbapenem-resistant (hv-CRKP), focusing on their antibiotic resistance and virulence profiles.
- - Researchers identified these strains through whole-genome analysis and several virulence tests, finding that 17.4% were CR-hvKP and 82.6% were hv-CRKP, with CR-hvKP displaying lower resistance to certain antibiotics.
- - The analysis revealed that while CR-hvKP and hv-CRKP had similar virulence potential, a predominant subclone ST11-KL64 emerged with high resistance and virulence, suggesting an evolving threat
Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis.
Inflamm Res
July 2023
School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China.
Article Synopsis
- Researchers are investigating the role of TREM-1 in myeloid dendritic cells (mDCs) and its therapeutic potential in systemic lupus erythematosus (SLE), a complex autoimmune disease influenced by epigenetic mechanisms and non-coding RNAs.
- * The study utilized bioinformatics to analyze gene expression differences between SLE patients and healthy individuals, identifying TREM-1 as a key gene related to disease progression and a potential biomarker in serum.
- * Findings showed that activating TREM-1 led to increased mDC activation and inflammation, while targeting it with the miRNA miR-150-5p could potentially mitigate SLE symptoms in lupus mice models.*
The emerging role of the piRNA/PIWI complex in respiratory tract diseases.
Respir Res
March 2023
Division of Pulmonary Medicine, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18-33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a subfamily of Argonaute (AGO) proteins that also contain the AGO family which bind to microRNA (miRNA). Recently studies indicate that piRNAs are not specific to in the mammalian germline, they are also expressed in a tissue-specific manner in a variety of human tissues and participated in various of diseases, such as cardiovascular, neurological, and urinary tract diseases, and are especially prevalent in malignant tumors in these systems.
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