1 results match your criteria: "China. wangcq1218@sh9hospital.org.cn.[Affiliation]"
Integrating Circle-Seq with transcriptomics reveals genome-wide characterization of extrachromosomal circular DNA for dilated cardiomyopathy.
Biol Direct
November 2024
Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200001, China.
Article Synopsis
- The study focused on extrachromosomal circular DNAs (eccDNAs) in human heart failure, particularly due to dilated cardiomyopathy (DCM), revealing their significance in heart disease.
- Researchers used advanced methods like Circle-Seq and RNA-Seq to identify and analyze eccDNAs in heart tissues from DCM patients compared to healthy controls.
- Findings showed that eccDNAs are derived from all chromosomes, often contain genes or gene fragments, and can influence gene expression in heart cells, potentially impacting the progression of heart failure.