Pilot Study of Cu(I) for PET Imaging of Melanoma.

At present, Cu(II) labeled tracers including CuCl have been widely applied in the research of molecular imaging and therapy. Human copper transporter 1 (hCTR1) is the major high affinity copper influx transporter in mammalian cells, and specially responsible for the transportation of Cu(I) not Cu(II). Thus, we investigated the feasible application of Cu(I) for PET imaging.

Does dual-time-point F-FDG PET/CT scan add in the diagnosis of hepatocellular carcinoma?

Objective: The aim of this study was to evaluate the usefulness of dual-time-point F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for patients with hepatocellular carcinoma (HCC).

Subjects And Methods: The 150 patients with clinically suspected liver malignancies underwent dual-time-point F-FDG PET/CT imaging. The maximum standardized uptake value (SUVmax) was calculated at both time points of PET imaging.

An imaging target TGF-β1 for hepatocellular carcinoma in mice.

Unlabelled: It has been reported that the positive detection rate of Fluorine-18-fluorodeoxyglucose (F-FDG) metabolism in positron emission tomography (PET) imaging, for the diagnosis of hepatocellular carcinoma (HCC) is only about 50%. In particular, F-FDG PET imaging is prone to false negative findings in HCC. Transforming growth factor-beta1 (TGF-β1) shows over expression rates in early HCC liver tissue growth and promotes tumor invasion and metastases.

Nineteen cases with synchronous multiple primary cancers studied by F-FDG PET/CT.

Objective: To evaluate the value of fluorine -18-fuoro-2-deoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in evaluating synchronous multiple primary cancers (SMPC).

Methods: Nineteen patients with pathologically-confirmed SMPC were collected. Clinical and F-FDG PET/CT characteristics of these patients were reviewed and analyzed.

The value of (18)F-FDG PET/CT in the diagnosis of uterine intravenous leiomyomatosis extended into the right atrium.

Intravenous leiomyomatosis (IVL) of the uterus is a rare neoplasm which usually occurs after hysterectomy. Due to its rarity and non-specific clinical manifestations, IVL is commonly misdiagnosed as malignant thrombus or thrombosis and treated inappropriately. Herein, we report an unusual case of a 51 years old woman with IVL without hysterectomy or abdominal manifestations.

Functional changes in patients with internet addiction disclosed by adenosine stressed cerebral blood flow perfusion imaging (99m)Tc-ECD SPET.

Objective: To investigate the abnormal cerebral blood flow (CBF) perfusion in patients with internet addiction (IA) and its possible association with IA severity.

Subjects And Methods: Thirty-five adolescents who met the criteria for IA and 12 matched healthy volunteers were recruited for (99m)Tc-ethylcysteinate dimer based CBF perfusion imaging with single photon emission tomography (SPET) both at rest and in adenosine-stressed state. Regional CBF (rCBF) was measured and compared between IA subjects and the controls.

Imaging by ¹⁸F-FDG PET/CT of diffuse large B-cell lymphoma with cellulitis.

Non-Hodgkin's lymphomas (NHL) quite often present in the neck but are seldom accompanied with cellulitis at the first diagnosis of the disease. We report a 56 year old woman with gradually neck swelling, which was initially treated as cellulitis. After examined by ultrasonography, computed tomography and after pathologically assessments, the diagnosis of large B-cell lymphoma was made.

Sarcomatoid carcinoma of the lung mimics aspergilloma on ¹⁸F-FDG PET/CT.

Primary PSC in the lung is a rare malignant cancer that represents a particularly aggressive subtype of non-small cell lung carcinomas (NSCLC) containing sarcoma or sarcoma-like components with spindle or giant cell features. The medical literature referring to imaging characteristics by fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) of these tumors is very limited. We present a case of PSC with air crescent and halo signs that resemble aspergilloma on the ¹⁸F-FDG PET/CT, scan.

Morphological Effect of Non-targeted Biomolecule-Modified MNPs on Reticuloendothelial System.

Magnetic nanoparticles (MNPs) with special morphology were commonly used as biomaterials, while morphological effects of non-targeted biomolecule-modified MNPs on biological behaviors were still unclear. In this research, spherical and rod-like Fe3O4 in a comparable size were synthesized and then surface-modified by bovine serum albumin (BSA) as a model of non-targeted biomolecule-modified MNPs. Morphological effects were featured by TEM and quantification of in vitro phagocytic uptake, as well as the in vivo quantification of particles in reticuloendothelial system (RES)-related organs of normal Kunming mice.

Primary pulmonary artery sarcoma differentiated from pulmonary thromboembolism by ventilation-perfusion scan. Long survival of the patient.

Unlabelled: Primary pulmonary artery sarcoma (PAS) is a rare and highly lethal tumor. Here, we report a case of a 53-year-old female with PAS who was initially diagnosed with chronic pulmonary thromboembolism (PTE) based on the results of a transthoracic Doppler echocardiogram, a contrast-enhanced computed tomography angiography, and a ventilation/perfusion lung scan.

Conclusion: We emphasize the difficulties in diagnosing PAS, the need to investigate this neoplasm in the differential diagnosis of PTE, the diagnostic value of different imaging techniques in the identification of the the tumor, and the efficacy of adjuvant chemotherapy in prolonging survival.

Optimized image acquisition parameters for imaging radioactive iodine-125 seed implantation for cancer treatment.

Objective: Using nuclear medicine imaging, we explored suitable acquisition window parameters for assessing the distribution of iodine-125 radioactive seed implantation.

Subjects And Methods: We studied 30 patients with various tumors (21 of which were liver cancers) who had received iodine-125 radioactive seed implantation and had undergone whole-body scintigraphy. Scintigraphy images were acquired at a magnification of 1.

Evaluation of the therapeutic response by (99m)Tc-ECD-SPET in a female with non-organic depression, generalized anxiety and heterophobia.

This is the case of a 33 years old female patient who was diagnosed with depression and heterophobia, which progressed to generalized anxiety according to the International Statistical Classification of Diseases and Health Related Problems, 10th Revision (ICD-10), Version for 2010 diagnostic criteria. The clinical symptoms of the patient were significantly improved after effective treatment. The patient underwent before and after treatment 99mTc-ethyl cysteinate dimmer ((99m)Tc-ECD) brain single-photon emission tomography (SPET).