[F]FDG PET/CT for predicting neoadjuvant PD-L1 blockade monotherapy treatment response in patients with locally advanced esophageal squamous cell carcinoma: a preliminary study.

Purpose: To investigate the predictive value of 2-[18F]-fluoro-2-deoxy-D-glucose ([F]FDG) PET/CT for evaluating primary tumor (PT) and lymph node (LN) responses after neoadjuvant programmed death-ligand 1 (PD-L1) blockade monotherapy in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC).

Methods: In the single-arm phase 1b NATION-1907 trial (NCT04215471), 23 patients with LA-ESCC received two cycles of neoadjuvant PD-L1 blockade Adebrelimab followed by surgery. Among these, 18 patients underwent [F]FDG PET/CT scans both before immunotherapy and prior to surgery.

Relationship between [F]FDG PET/CT findings and claudin 18.2 expression in metastatic gastric cancer.

Aim: Given that claudin 18.2 (CLDN18.2) is a cell surface protein specifically expressed by gastric cancer cells, anti-CLDN18.

Expert consensus on workflow of PET/CT with long axial field-of-view.

Purpose: Positron emission tomography/computed tomography (PET/CT) imaging has been widely used in clinical practice. Long axial field-of-view (LAFOV) systems have enhanced clinical practice by leveraging their technological advantages and have emerged as the new state-of-the-art PET imaging modalities. A consensus was conducted to explore expert views in this emerging field to comprehensively elucidate the proposed workflow in LAFOV PET/CT examinations and highlight the potential challenges inherent in the workflow.

Comparative benefits of Ki and SUV images in lesion detection during PET/CT imaging.

Background: Clinical application of the tracer net influx rate (Ki) imaging in PET/CT remains limited, due to a lack of evidence demonstrating the superiority of Ki images in lesion detection, and guidelines on when to utilize Ki images. This study aims to compare the benefits of Ki and standardized uptake value (SUV) images in lesion detection during PET/CT imaging. By analyzing the performance of both techniques in identifying tumor lesions, the study seeks to provide guidance for the clinical application of Ki images.

A head-to-head comparison of F-FDG PET/CT and F-FDG PET/MR in patients with nasopharyngeal carcinoma under different disease settings.

Objective: Positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) are complementary in staging of nasopharyngeal carcinoma (NPC). The combination of MRI and functional imaging from PET in PET/MR is promising in NPC management. Diagnostic performance of PET/CT and PET/MR was compared in 46 patients with histologically confirmed NPC under different disease scenarios, including primary non-metastatic cases, primary metastatic cases, recurrence and/or metastasis after treatment, and post-treatment follow-up cases.

Total-body dynamic PET/CT imaging reveals kinetic distribution of [N]NH in normal organs.

Purpose: To systematically investigate kinetic metrics and metabolic trapping of [N]NH in organs.

Methods: Eleven participants performed total-body [N]NH dynamic positron emission tomography (PET). Regions of interest were drawn in organs to obtain time-to-activity curves (TACs), which were fitted with an irreversible two-tissue compartment model (2TC) to investigate constant rates K, k and k, and to calculate Ki.

Parametric net influx rate imaging of Ga-DOTATATE in patients with neuroendocrine tumors: assessment of lesion detectability.

Objectives: There has been developed a clinical dynamic total-body Ga-DOTATATE PET/CT imaging protocol that allows quantitative imaging of net influx rate (K). Using qualitative and quantitative analyses of clinical studies, this retrospective study aims to assess whether parametric K images improve lesion detectability.

Methods: Using a 194-cm axial field-of-view PET/CT scanner, 52 patients with neuroendocrine tumors underwent a 60-min dynamic total-body Ga-DOTATATE scan.

Phantom study and clinical application of total-body F-FDG PET/CT imaging: How to use small voxel imaging better?

Background: Conventional PET/CT imaging reconstruction is typically performed using voxel size of 3.0-4.0 mm in three axes.

The earliest optimal timing for total-body Ga-fibroblast activation protein inhibitor-04 PET scans: an evidence-based single-centre study.

Objectives: To investigate the earliest optimal timing for positron emission tomography (PET) scans after Ga-fibroblast activation protein inhibitor-04 ([Ga]Ga-FAPI-04) injection.

Methods: This prospective study enrolled patients who underwent 60-min dynamic Ga-FAPI-04 total-body PET/CT scans; the images were reconstructed at 10-min intervals (G0-10, G10-20, G20-30, G30-40, G40-50, and G50-60), and the [Ga]Ga-FAPI-04 uptake patterns were evaluated. The standardised uptake value (SUV), liver signal-to-noise ratio (SNR), and lesion-to-background ratios (LBRs) for different time windows were calculated to evaluate image quality and lesion detectability.

A single-center, multi-factor, retrospective study to improve the diagnostic accuracy of primary prostate cancer using [Ga]Ga-PSMA-11 total-body PET/CT imaging.

Purpose: To improve the diagnostic accuracy of initial detection in patients with suspected primary prostate cancer (PCa).

Methods: Eighty-four patients who underwent Gallium-68-labeled prostate-specific membrane antigen ([Ga]Ga-PSMA-11) total-body positron emission tomography/computed tomography (PET/CT) imaging before treatment in our department were enrolled. The maximum standard uptake value (SUVmax) of the prostate (SUVmax-PSMA), liver (SUVmax-PSMA-L), and mediastinal blood pool (SUVmax-PSMA-M) was measured using [Ga]Ga-PSMA-11 total-body PET/CT imaging.

Development and Validation of PET/CT-Based Nomogram for Preoperative Prediction of Lymph Node Status in Esophageal Squamous Cell Carcinoma.

Purpose: This study was conducted to predict the lymph node status and survival of esophageal squamous cell carcinoma before treatment by PET-CT-related parameters.

Methods: From January 2013 to July 2018, patients with pathologically diagnosed ESCC at our hospital were retrospectively enrolled. Completed esophagectomy and two- or three-field lymph node dissections were conducted.

Head-to-head intra-individual comparison of total-body 2-[F]FDG PET/CT and digital PET/CT in patients with malignant tumor: how sensitive could it be?

Objectives: To comparatively evaluate the lesion-detecting ability of 2-[F]FDG total-body PET/CT (TB PET/CT) and conventional digital PET/CT.

Methods: This study enrolled 67 patients (median age, 65 years; 24 female and 43 male patients) who underwent a TB PET/CT scan and a conventional digital PET/CT scan after a single 2-[F]FDG injection (3.7 MBq/kg).

Comparison of F-FDG PET/MR and PET/CT for pretreatment TNM staging of hilar cholangiocarcinoma.

Purpose: F-FDG PET/MR has been applied to the diagnosis and preoperative staging in various tumor types; however, reports using PET/MR in hilar cholangiocarcinoma (HCCA) are rare. We investigated the value of PET/MR for preoperative staging and compared it with PET/CT in HCCA.

Methods: Fifty-eight patients with HCCA confirmed by pathology were retrospectively analyzed.

The added value of F-FDG PET/MRI multimodal imaging in hepatocellular carcinoma for identifying cytokeratin 19 status.

Purpose: In hepatocellular carcinoma (HCC), cytokeratin 19(CK19) has been proven to be associated with clinical aggressiveness. Therefore, this study aimed to explore the added value of F-FDG PET/MRI in predicting CK19 status in HCC.

Methods: Sixty-six patients who underwent whole-body or abdominal F-FDG PET/MRI after conventional PET/CT for HCC were retrospectively enrolled.

One-stop [F]FDG and [Ga]Ga-DOTA-FAPI-04 total-body PET/CT examination with dual-low activity: a feasibility study.

Purpose: Positron emission tomography/computed tomography (PET/CT) based on fibroblast activation protein inhibitors (FAPI) has shown complementary values to 2-[F]-fluoro-2-deoxy-D-glucose ([F]FDG) in cancer imaging. This study aimed to investigate the feasibility of a one-stop FDG-FAPI dual-tracer imaging protocol with dual-low activity for oncological imaging.

Methods: Nineteen patients with malignancies underwent one-stop [F]FDG (0.

Quantitative flow ratio derived pullback pressure gradient and CZT-SPECT measured longitudinal flow gradient for hemodynamically significant coronary artery disease.

Background: Whether physiological coronary diffuseness assessed by quantitative flow reserve (QFR) pullback pressure gradient (PPG) correlates with longitudinal myocardial blood flow (MBF) gradient and improves diagnostic performances for myocardial ischemia remains unknown.

Methods And Results: MBF was measured in mL g min with Tc-MIBI CZT-SPECT at rest and stress, corresponding myocardial flow reserve (MFR = MBF stress/MBF rest) and relative flow reserve (RFR = MBF stenotic area/MBF reference) were calculated. Longitudinal MBF gradient was defined as apical and basal left ventricle MBF gradient.

An exploration of the feasibility and clinical value of half-dose 5-h total-body F-FDG PET/CT scan in patients with Takayasu arteritis.

Purpose: To explore the feasibility and clinical value of 5-h delayed F-fluorodeoxyglucose (F-FDG) total-body (TB) positron emission tomography/computed tomography (PET/CT) in patients with Takayasu arteritis (TA).

Methods: This study included nine healthy volunteers who underwent 1-, 2.5-, and 5-h triple-time TB PET/CT scans and 55 patients with TA who underwent 2- and 5-h dual-time TB PET/CT scans with 1.

Ultralow-dose [F]FDG PET/CT imaging: demonstration of feasibility in dynamic and static images.

Objectives: Validation of [F]FDG PET/CT at ultralow-dose (0.37 MBq/kg) and compared to imaging at half-dose (1.85 MBq/kg).

Ultra-low-dose CT reconstructed with the artificial intelligence iterative reconstruction algorithm (AIIR) in F-FDG total-body PET/CT examination: a preliminary study.

Purpose: To investigate the feasibility of ultra-low-dose CT (ULDCT) reconstructed with the artificial intelligence iterative reconstruction (AIIR) algorithm in total-body PET/CT imaging.

Methods: The study included both the phantom and clinical parts. An anthropomorphic phantom underwent CT imaging with ULDCT (10mAs) and standard-dose CT (SDCT) (120mAs), respectively.

A personal acquisition time regimen of Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study.

Background: The injection activity of tracer, acquisition time, patient-specific photon attenuation, and large body mass, can influence on image quality. Fixed acquisition time and body mass related injection activity in clinical practice results in a large difference in image quality. Thus, this study proposes a patient-specific acquisition time regimen of  Ga-DOTATATE total-body positron emission tomography-computed tomography (PET/CT) to counteract the influence of body mass (BM, kg) on image quality, and acquire an acceptable and constant image of patients with neuroendocrine tumors (NETs).