1 results match your criteria: "China. panjy1231@wzhospital.cn.[Affiliation]"
Effects of immune cells in mediating the relationship between inflammatory bowel disease and pyoderma gangrenosum: a two-sample, two-step mendelian randomization study.
Arch Dermatol Res
January 2025
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Article Synopsis
- The study investigates the link between pyoderma gangrenosum (PG) and inflammatory bowel disease (IBD), highlighting that while the exact cause of their co-occurrence is unclear, there is evidence suggesting IBD increases the risk of PG.
- Researchers utilized genome-wide association study data to analyze the genetic relationship and potential mediating role of immune cells between the two conditions, employing various statistical techniques.
- The results indicated that IBD significantly raises the risk of PG, with specific types of IBD (ulcerative colitis and Crohn's disease) strongly correlating with this risk, and CD4 regulatory T cells playing a key mediating role in this interaction.