1 results match your criteria: "China. cl_xie1987@wzhospital.cn.[Affiliation]"
NAD-boosting agent nicotinamide mononucleotide potently improves mitochondria stress response in Alzheimer's disease via ATF4-dependent mitochondrial UPR.
Cell Death Dis
October 2024
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Article Synopsis
- Mitochondrial dysfunction plays a crucial role in the development of Alzheimer's disease (AD), and boosting the mitochondrial stress response (MSR) may help slow neurodegeneration, although research in this area is limited.* -
- The study investigates how nicotinamide mononucleotide (NMN), a NAD-boosting agent, enhances MSR in AD models by restoring NAD levels and activating the ATF4-dependent unfolded protein response (UPR). * -
- NMN supplementation in mouse models of AD shows promising results, including reduced mitochondrial damage, improved hippocampal function, and enhanced overall healthspan, indicating that targeting MSR could be a viable therapeutic strategy for AD.*