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Causal pathways in Lymphoma: The role of serum metabolites and immune cells determined by Mendelian randomization.

Int Immunopharmacol

January 2025

Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Background: Prior research has demonstrated significant roles of metabolites and immune cells in the progression of lymphoma. Mendelian randomization studies have been conducted to assess the causal relationships among serum metabolites, immune cells, and lymphoma, further exploring the mediating role of serum metabolites.

Methods: Using summary-level data from genome-wide association studies (GWAS), we applied two-sample Mendelian randomization (TSMR) techniques, including Inverse Variance Weighted (IVW), Weighted Median, MR-Egger, Simple Mode, and Weighted Mode.

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