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Bioorg Chem
July 2024
Department of Hematology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address:
Thrombosis leads to elevated mortality rates and substantial medical expenses worldwide. Human factor IXa (HFIXa) protease is pivotal in tissue factor (TF)-mediated thrombin generation, and represents a promising target for anticoagulant therapy. We herein isolated novel DNA aptamers that specifically bind to HFIXa through systematic evolution of ligands by exponential enrichment (SELEX) method.
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