1 results match your criteria: "China. Collarative Innovation Center of Systems Biomedicine[Affiliation]"
CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer.
Cancer Res
October 2015
State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. Collarative Innovation Center of Systems Biomedicine, Sanghai, China.
The tumor-promoting chemokine CCL5 has been implicated in malignant transformation of breast epithelial cells, with studies to date focusing mainly on basal-type breast cancers. In this study, we investigated the consequences of CCL5 deletion in the MMTV-PyMT transgenic mouse model of luminal breast cancer. In this model, primary tumor burden and pulmonary metastases were reduced significantly in CCL5-deficient subjects, an effect found to be associated with a deficit of Th2 (IL4⁺CD4⁺ T) cells.
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