3 results match your criteria: "China. 304237@hospital.cqmu.edu.cn.[Affiliation]"
Neutrophil Extracellular Traps Induce Brain Edema Around Intracerebral Hematoma via ERK-Mediated Regulation of MMP9 and AQP4.
Transl Stroke Res
December 2024
Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Perihematomal edema (PHE) significantly aggravates secondary brain injury in patients with intracerebral hemorrhage (ICH), yet its detailed mechanisms remain elusive. Neutrophil extracellular traps (NETs) are known to exacerbate neurological deficits and worsen outcomes after stroke. This study explores the potential role of NETs in the pathogenesis of brain edema following ICH.
View Article and Find Full Text PDFNPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8T lymphocyte cuproptosis in glioma.
Cell Mol Life Sci
October 2024
Department of Neurosurgery, The Second Affiliated Hospital of Chongqing, Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Article Synopsis
- NPRL2, a tumor suppressor, is often downregulated in glioma, leading to aggressive tumor growth and unclear interactions with immune cells.
- The study investigates how NPRL2 influences the degradation of Galectin-3 (Gal-3) via TRIM16, affecting immune cell functions and copper uptake in CD8T lymphocytes.
- Results show that NPRL2 enhances TRIM16 expression and reduces Gal-3 levels, which improves CD8T cell recruitment and protects them from Gal-3-related damage, suggesting a potential therapeutic target for restoring immune function in glioma.
Comparison of outcomes between intracapsular resection and pseudocapsule-based extracapsular resection for pituitary adenoma: a systematic review and meta-analysis.
BMC Neurol
February 2022
Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Article Synopsis
- Transsphenoidal surgery is the primary treatment for pituitary adenomas, with intracapsular resection (IR) being the conventional approach, while extracapsular resection (ER) has emerged as an alternative that removes tissue outside the pseudocapsule.
- A systematic review of 7 studies involving 1,768 cases found that ER showed better biochemical remission and, in some analyses, a higher rate of complete tumor resection compared to IR, but there was no major difference in complication rates between the two techniques.
- Although ER was associated with some advantages, IR appeared to lower the risk of intraoperative cerebrospinal fluid (CSF) leakage; further well