2 results match your criteria: "China. 2h4841@hospital.cqmu.edu.cn.[Affiliation]"
PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research.
Diagn Pathol
March 2024
Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Article Synopsis
- This research looked at a protein called PKM2 to see how it affects a type of throat cancer known as hypopharyngeal carcinoma (HPC) and its ability to spread to lymph nodes.
- They found that higher levels of PKM2 are linked to worse outcomes for patients with this cancer.
- The studies showed that PKM2 helps cancer cells move and grow and might be useful for finding new treatments in the future.
Background: Lymphatic metastasis was an independent prognostic risk factor for hypopharyngeal carcinoma and was the main cause of treatment failure. The purpose of this study was to screen the differential genes and investigate the mechanism of lymphatic metastasis in hypopharyngeal carcinoma.
Methods: Transcriptome sequencing was performed on primary tumors of patients, and differential genes were screened by bioinformatics analysis.