3 results match your criteria: "China-Japan Union Hospital of Jinlin University[Affiliation]"
Recaticimab Monotherapy for Nonfamilial Hypercholesterolemia and Mixed Hyperlipemia: The Phase 3 REMAIN-1 Randomized Trial.
J Am Coll Cardiol
November 2024
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:
Article Synopsis
- Monoclonal antibodies like recaticimab target PCSK9 to effectively lower LDL cholesterol levels, offering an alternative to more frequent treatments due to its long-acting nature.
- The study evaluated recaticimab's effectiveness and safety in patients with nonfamilial hypercholesterolemia and low-to-moderate atherosclerotic cardiovascular disease risk, comparing various dosing strategies.
- Results showed significant LDL-C reductions (up to 52.8%) compared to placebo, with safety profiles similar to that of placebo, suggesting recaticimab may provide a flexible treatment option for patients.
M1 macrophage-derived exosome-encapsulated cisplatin can enhance its anti-lung cancer effect.
Minerva Med
October 2023
Department of Respiratory Medicine, China-Japan Union Hospital of Jinlin University, Changchun, China -
Background: The aim of this study was to study the efficacy of cisplatin-loaded M1 macrophage secreted-exosomes (DDP-M1-Exos) in enhancing DDP antitumor effect.
Methods: M1-Exos were first extracted using density gradient centrifugation, and the DDP-M1-Exos system was established via electroporation. Then, the morphology, particle size and maker proteins of the DDP-M1-Exos system were assessed using transmission electron microscope, DLS and Western blotting (WB), respectively.
Long noncoding RNA promotes proliferation and invasion by targeting miR-141 in papillary thyroid carcinoma.
Onco Targets Ther
August 2018
College of Bioengineering, Jilin Agricultural Science and Technology University, Jilin City 132101, People's Republic of China,
Background: The long noncoding RNA X-inactive specific transcript () was reported to play vital roles in tumor progression. In the present study, we determined the regulatory function of in papillary thyroid carcinoma (PTC).
Materials And Methods: expression was determined in PTC tissues and cell lines by quantitative real-time polymerase chain reaction (PCR) (qRT-PCR).