Intratumoral TIGIT CD8 T-cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer.

Background: T-cell immunoglobulin and ITIM domain (TIGIT) is identified as a novel checkpoint receptor that can facilitate immune escape via mediating T-cell exhaustion in tumors. However, the clinical significance and immune contexture correlation of intratumoral TIGIT CD8 T-cells remain to be further explored in muscle-invasive bladder cancer (MIBC).

Methods: 259 patients with MIBC from two clinical centers (Zhongshan Hospital, n=141; Shanghai Cancer Center, n=118) were analyzed to evaluate the prognostic value and immune contexture association of TIGIT CD8 T-cells through immunohistochemistry.