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Blood pressure reduction in acute ischemic stroke according to time to treatment: a subgroup analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial.

J Hypertens

June 2017

aSchool of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China bTulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA cAffiliated Hospital of Hebei United University, Shijiazhuang, Hebei dFirst Affiliated Hospital of China Medical University, Shenyang, Liaoning eYutian County Hospital, Tangshan, Hebei fKerqin District First People's Hospital of Tongliao City, Tongliao, Inner Mongolia gAffiliated Hospital of Nantong University, Nantong, Jiangsu hSchool of Public Health, Taishan Medical College, Tai'an, Shandong iAffiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu jThe 88th Hospital of PLA kFeicheng City People's Hospital, Tai'an, Shandong lTongliao Municipal Hospital, Tongliao, Inner Mongolia mSiping Central Hospital, Siping nJilin Central Hospital, Jilin City oGeneral Hospital of First Automobile Works, Changchun, Jilin pTangshan Worker's Hospital, Tangshan, Hebei qFirst Affiliated Hospital of Jilin University, Changchun, Jilin rDongping County People's Hospital, Tai'an, Shandong sSecond People's Hospital of Huaian City, Huai'an, Jiangsu tAffiliated Hospital of Chengde Medical College, Chengde, Hebei uKailuan General Hospital, Tangshan, Hebei, China vTulane University School of Medicine, New Orleans, Louisiana, USA.

Objective: The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment.

Methods: We randomly assigned 4071 acute ischemic stroke patients with elevated SBP to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization.

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