2 results match your criteria: "China Xinjiang Key Laboratory of Clinical Drug Research[Affiliation]"
[Expression and clinical significance of PIKFYVE gene in hepatocellular carcinoma analyzed based on TCGA database and experimental validation].
Zhonghua Gan Zang Bing Za Zhi
November 2024
Pharmaceutical Department of the First Affiliated Hospital of Xinjiang Medical University, Urumqi830054, China Xinjiang Key Laboratory of Clinical Drug Research, Urumqi830011, China.
To investigate the expression and clinical significance of human FYVE finger-containing phosphoinositide kinase (PIKFYVE) in hepatocellular carcinoma (HCC) on the basis of cancer genome atlas (The cancer genome atlas, TCGA) database analysis and clinical samples experimental validation. Based on the data information of 424 clinical samples (including 374 cases of HCC tissues and 50 cases of nontumorous liver tissues) in the TCGA database, Cox regression analysis and Kaplan-Meier method were used to analyse the relationship between the PIKFYVE mRNA expression and the clinical characteristics, prognosis for survival of HCC patients. The relationship between the PIKFYVE gene and immune cell infiltration was examined by correlation analysis between the PIKFYVE gene and 24 immune cells.
View Article and Find Full Text PDF[Mechanism of Panax notoginseng saponins in treating diabetic kidney disease based on network pharmacology and experimental verification].
Zhongguo Zhong Yao Za Zhi
September 2024
State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Pharmaceutical Department of the First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, China.
Article Synopsis
- This study investigates the effects of Panax notoginseng saponins (PNS) on diabetic kidney disease (DKD) using network pharmacology, molecular docking, and animal experiments.
- Key targets identified for PNS include AKT1, STAT3, and others, with relevant pathways related to cancer and signaling highlighted in the analysis.
- Animal trials showed that PNS significantly lowered blood glucose levels and improved kidney damage in diabetic mice, indicating its potential therapeutic effect on DKD.