Study of the spatial strength distribution patterns and microstructure characteristics of ultra-fine tailings cemented paste backfill.

In this study, the spatial distribution of the mechanical strength of ultra-fine tailings cemented paste backfill (UCPB) in underground stopes was examined, and the micro-mechanism responsible for differences in spatial strength performance via changes in particle deposition was elucidated. To better understand this phenomenon, we constructed a similar backfilling stope model using the ultra-fine tailings of a gold mine. We manufactured specimens at different spatial locations and conducted a novel series of tests, including uniaxial compressive strength, shear strength, and conventional triaxial tests, to obtain the strength parameters in different spatial distributions.

Data mining and analysis of adverse events of Vedolizumab based on the FAERS database.

This study aims to mine and analyze adverse events (AEs) of Vedolizumab based on the FAERS database to better understand its safety and potential risks in the real world. Data from the second quarter of 2014 to the third quarter of 2023 were collected, employing various signal mining methods such as Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM). The study gathered 14,753,012 reports of AEs, of which 46,726 were related to Vedolizumab.

Universal, untargeted detection of bacteria in tissues using metabolomics workflows.

Fast and reliable identification of bacteria directly in clinical samples is a critical factor in clinical microbiological diagnostics. Current approaches require time-consuming bacterial isolation and enrichment procedures, delaying stratified treatment. Here, we describe a biomarker-based strategy that utilises bacterial small molecular metabolites and lipids for direct detection of bacteria in complex samples using mass spectrometry (MS).

The fully bio-based bilayered flame retardant treatment for paper via natural bio-materials.

In this paper, we report a novel method for enhancing the flame retardancy of wood-based paper by utilizing natural biomaterials. The research constructed a bilayered structure coating on paper fiber surfaces, incorporating mixed starch (MS), adenosine triphosphate (ATP), and phytic acid (PA) as natural bio-based flame retardants. The structural configuration of the coating comprises MS/ATP and MS/PA, which were sequentially assembled as bottom and top parts, respectively, through pneumatic spraying.

Technical and Biological Biases in Bulk Transcriptomic Data Mining for Cancer Research.

Cancer research has been significantly advanced by the integration of transcriptomic data through high-throughput sequencing technologies like RNA sequencing (RNA-seq). This paper reviews the transformative impact of transcriptomics on understanding cancer biology, focusing on the use of extensive datasets such as The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx). While transcriptomic data provides crucial insights into gene expression patterns and disease mechanisms, the analysis is fraught with technical and biological biases.

Untargeted metabolomics combined with lipidomics revealed the effects of myocardial infarction and exercise rehabilitation on blood circulation metabolism of patients based on liquid chromatography-mass spectrometry.

Myocardial infarction (MI) is a major cause of death worldwide. Exercise rehabilitation (ER) is a powerful tool to improve life quality and prognosis of MI patients. Herein, we developed an untargeted metabolomics combined with lipidomics method to qualitatively and quantitatively detect metabolites in plasma.

Ancestral Nitrilase Mining and Semi-Rational Engineering for Enhanced Thermal Stability in Rapeseed Meals-Derived Nitriles Degradation.

Rapeseed meal (RSM), a protein-rich byproduct, holds potential as a high-quality animal feed, but nitrile compounds derived from glucosinolates (GSLs) in RSM pose a toxicity risk. Nitrilases, enzymes that hydrolyze toxic nitriles to carboxylic acids, offer a potential solution for detoxification. However, the low thermal stability of nitrilases restricts their industrial applicability.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

The crop mined phosphorus nutrition via modifying root traits and rhizosphere micro-food web to meet the increased growth demand under elevated CO.

Elevated CO (eCO) stimulates productivity and nutrient demand of crops. Thus, comprehensively understanding the crop phosphorus (P) acquisition strategy is critical for sustaining agriculture to combat climate changes. Here, wheat ( L) was planted in field in the eCO (550 µmol mol) and ambient CO (aCO, 415 µmol mol) environments.

Progressive Evolution of Flow and Heat Transfer Channels in Hot Dry Rock Stimulated by Liquid Nitrogen Cold Shock.

Hot dry rock (HDR) is a novel green, low-carbon energy. Its development requires the creation of fracture channels in deep thermal reservoirs. Traditional methods such as hydraulic fracturing have limited effectiveness in reservoir stimulation, so a method of liquid nitrogen cold shock was proposed.

Study on Fluidity and Deposition Characteristics of Air-Containing Filling Slurry.

With the continuous exploitation of global mineral resources, backfill technology for gob areas has become a crucial aspect of mine safety and sustainable development. As a primary method of gob area backfill, slurry backfill directly relates its flow properties and filling height to the efficiency and safety of mine extraction. To enhance the flow properties of the slurry and increase its filling height, a research study on the flow and deposition characteristics of a gas-containing filling slurry was conducted using a combination of theoretical analysis, laboratory experiments, and field tests.

Experimental Investigation of the Effect of Microstructure on Coalbed Methane Adsorption Characteristics Affected by Chemical Solvents.

Coalbed methane (CBM) reservoir modification based on chemical solvent treatment could change the coal microstructure, which further affects the adsorption capacity and flow characteristics of this clean energy. Coal samples were extracted by tetrahydrofuran (THF), carbon disulfide (CS), and hydrochloric acid (HCl). Low-pressure nitrogen adsorption, carbon dioxide adsorption, Fourier transform infrared spectroscopy, and methane isothermal adsorption test were adopted.

Understanding the coupled relationship between regional longevity and physical geographical environment in Hechi, Guangxi, China.

Healthy ageing plays an important role in ageing societies in many countries, and centenarians are a sign of longevity. Longevity and its determinants have become issues of global concern and also a focus of research. Although many disciplines have conducted out a series of studies on longevity phenomena, few studies have systematically considered the impact of geographical environmental factors.

Insertional mutagenesis of AIDA or CYP720B1 in the green alga Chlamydomonas reinhardtii confers copper(II) tolerance and increased biomass.

The widespread use of copper (Cu) in industrial and agricultural settings leads to the accumulation of excess Cu within aquatic ecosystems, posing a threat to organism health. Microalgal bioremediation has emerged as a popular and promising solution to mitigate the risks. Nevertheless, the genetic underpinnings and engineering tactics involved in heavy metal bioremediation by microalgae remain inadequately elucidated.

Salvianic acid A ameliorates atherosclerosis through metabolic-dependent anti-EndMT pathway and repression of TGF-β/ALK5 signaling.

Background: Endothelial-to-mesenchymal transition (EndMT) has been identified as a key factor to the initiation and progression of the pathogenesis of atherosclerosis (AS). Salvianic acid A (SAAS) is the primary water-soluble bioactive ingredient found in Salvia miltiorrhiza, is renowned for its therapeutic effects on cardiovascular diseases. However, the efficacy and mechanisms of SAAS in treating EndMT-induced AS remain underexplored.

The dynamic characteristics of the shearer cable drag system.

Based on the 5615 working face of Beisu Coal Mine, a virtual prototype of the shearer cable drag system was developed using the MG2×70/325-BWD electric traction shearer as the carrier, in combination with CERO and ADAMS software. The shearer cable was equivalently modeled using the discrete rigid body method to study the dynamic characteristics of the drag system. This research provides a foundation for the design and optimization of both the cable and cable clamps.

Data mining of adverse drug event signals with Nirmatrelvir/Ritonavir from FAERS.

Nirmatrelvir/Ritonavir, acting as an effective agent against COVID-19, has achieved considerable results in clinical studies in terms of drug efficacy. However, there is little research about its medication safety. Based on the FDA adverse event reporting system (FAERS) database, this study aims to mine the adverse reaction signals of the latest major recommended drug Nirmatrelvir/Ritonavir for the antiviral treatment of COVID-19, so as to provide a basis for safe and rational drug use.

Assessment of grazing livestock balance on the Eastern Mongolian Plateau based on remote sensing monitoring and grassland carrying capacity evaluation.

Rational utilization of natural resources is crucial in arid and semi-arid areas due to their vulnerable ecosystems and low resource resilience. Achieving a balance between grassland production and livestock grazing, known as the pasture-livestock balance, is essential for the sustainable development of grassland resources on the Mongolian Plateau (MP). This study focuses on the grassland regions of 8 provinces in eastern Mongolia (MNG) and 7 leagues in Inner Mongolia (IMNG), China, during the period from 2018 to 2022.