Ultrabroadband integrated electro-optic frequency comb in lithium tantalate.

The integrated frequency comb generator based on Kerr parametric oscillation has led to chip-scale, gigahertz-spaced combs with new applications spanning hyperscale telecommunications, low-noise microwave synthesis, light detection and ranging, and astrophysical spectrometer calibration. Recent progress in lithium niobate (LiNbO) photonic integrated circuits (PICs) has resulted in chip-scale, electro-optic (EO) frequency combs, offering precise comb-line positioning and simple operation without relying on the formation of dissipative Kerr solitons. However, current integrated EO combs face limited spectral coverage due to the large microwave power required to drive the non-resonant capacitive electrodes and the strong intrinsic birefringence of LiNbO.

A method for monitoring three dimensional surface deformation in mining areas combining SBAS-InSAR, GNSS and probability integral method.

In the process of mineral resource extraction, monitoring surface deformation is crucial for ensuring the safety of engineering and ground infrastructure. Monitoring complete three-dimensional surface deformation is particularly significant. Traditional synthetic aperture radar (InSAR) technology provides deformation components only along the line of sight (LOS) and often lacks sufficient effective data in vegetation-covered mining areas and mining subsidence centers.

An Integrated Strategy for Deciphering the Action Mechanism of Emplastrum: Prescription Analysis- Component Identification- Virtual Screening and Affinity Testing in the Case of Yaoshen Gao.

Ethnopharmacological Relevance: Emplastrum has a long history of use in the clinical practice of traditional Chinese medicine (TCM), valued for its convenient external application and pronounced therapeutic effects. Traditionally, the emplastrum was composed of numerous herbal medicines. The elucidation of their mechanisms of action are of great importance.

Graph anomaly detection based on hybrid node representation learning.

Anomaly detection on graph data has garnered significant interest from both the academia and industry. In recent years, fueled by the rapid development of Graph Neural Networks (GNNs), various GNNs-based anomaly detection methods have been proposed and achieved good results. However, GNNs-based methods assume that connected nodes have similar classes and features, leading to issues of class inconsistency and semantic inconsistency in graph anomaly detection.

A novel method of species-specific molecular target mining and accurate discrimination of Bacillus cereus sensu lato.

Bacillus cereus, a member of the Bacillus cereus sensu lato (B. cereus s.l.

Optimizing multi label student performance prediction with GNN-TINet: A contextual multidimensional deep learning framework.

As education increasingly relies on data-driven methodologies, accurately predicting student performance is essential for implementing timely and effective interventions. The California Student Performance Dataset offers a distinctive basis for analyzing complex elements that affect educational results, such as student demographics, academic behaviours, and emotional health. This study presents the GNN-Transformer-InceptionNet (GNN-TINet) model to overcome the constraints of prior models that fail to effectively capture intricate interactions in multi-label contexts, where students may display numerous performance categories concurrently.

Identification of KRT16 and ANXA10 as cell cycle regulation genes for lung adenocarcinoma based on self-transcriptome sequencing of surgical samples and TCGA public data mining.

Aim: This study aimed to identify the genes associated with the development of lung adenocarcinoma (LUAD) and potential therapeutic targets.

Methods: Differentially expressed genes (DEGs) were identified by self-transcriptome sequencing of tumor tissues and paracancerous tissues resected during surgery and combined with The Cancer Genome Atlas (TCGA) data to screen for the genes associated with LUAD prognosis. The expression was validated at mRNA and protein levels, and the gene knockdown was used to examine the impact and underlying mechanisms on lung cancer cells.

Broad-spectrum applications of plant growth-promoting rhizobacteria (PGPR) across diverse crops and intricate planting systems.

Multifunctional plant growth-promoting rhizobacteria (PGPR) have garnered significant attention in agricultural applications; however, a few have applied them in crop rotation or intercropping fields. To identify PGPR with strong colonization ability and broad spectrum benefit, we screened strains from the local tobacco rhizosphere and evaluated their growth-promoting effects across various crops and farming systems. In this study, strain L8, identified as , was selected as a multifunctional PGPR capable of producing indole-3-acetic acid (IAA), solubilizing potassium, and mobilizing both organic and inorganic phosphorus.

Measuring high-efficiency perfect composite vortex beams with reflective metasurfaces in microwave band.

Optical vortex beams carrying orbit angular momentum have attracted significant attention recently. Perfect vortex beams, characterized by their topological charge-independent intensity profile, have important applications in enhancing communication capacity and optimizing particle manipulation. In this paper, metal-insulator-metal copper-coin type reflective metasurfaces are proposed to generate perfect composite vortex beams in X-band.

Genetically-modified activation strategy facilitates the discovery of sesquiterpene-derived metabolites from .

Genome mining has revealed that spp. possess numerous down-regulated or cryptic biosynthetic gene clusters (BGCs). This finding hinted that our investigation of fungal secondary metabolomes is limited.

Hepatotoxicity of statins: a real-world study based on the US Food and Drug Administration Adverse Event Reporting System database.

Background: Statins, as an important class of lipid-lowering drugs, play a key role in the prevention and treatment of cardiovascular diseases. However, with their widespread use in clinical practice, some adverse events have gradually emerged. In particular, the hepatotoxicity associated with statins use has become one of the clinical concerns that require sufficient attention.

A study on the exploration of mild cognitive impairment in Parkinson's disease based on decision-making cognitive computing.

Mild cognitive impairment in Parkinson's disease (PD-MCI) as an independent risk factor for dementia in Parkinson's disease has prognostic value in predicting dementia in PD patients. It was found that the calculation of cognitive function decision-making could better evaluate the cognitive function of PD-MCI. Therefore, this study explored deficits in decision-making cognitive function in PD-MCI population, and mined novel digital biomarkers for recognizing early cognitive decline in PD-MCI through an independently designed maze decision-making digital assessment paradigm.

An orphan viral genome with unclear evolutionary status sheds light on a distinct lineage of flavi-like viruses infecting plants.

Advancements in high-throughput sequencing and associated bioinformatics methods have significantly expanded the RNA virus repertoire, including novel viruses with highly divergent genomes encoding "orphan" proteins that apparently lack homologous sequences. This absence of homologs in routine sequence similarity search complicates their taxonomic classification and raises a fundamental question: Do these orphan viral genomes represent viruses? In 2022, an orphan viral genome encoding a large polyprotein was identified in alfalfa () and thrips (), and named Snake River alfalfa virus (SRAV). SRAV was initially proposed as an uncommon flavi-like virus identified in a plant host distantly related to family .

Analysis report on trends in public infectious disease control in China.

Background: The prevention and control of public infectious diseases is a significant issue in the global health sector. Controlling infectious diseases is crucial for maintaining public health. As the most populous country in the world, China still faces a series of new challenges in the control of public infectious diseases.

Genome mining of albocandins A-E from sp. YINM00030.

The natural products of 2,5-diketopiperazines have attracted considerable attention due to their potent pharmacological activities. Guided by genome mining techniques, five albonoursin analogues, designated as albocandins A-E (1-5), were isolated from sp. YINM00030, an actinomycete sourced from the rhizosphere soil of medicinal plants.

Tolerance and accumulation characteristics of Brassica chinensis L. under the interactive treatments of lanthanum, cerium, and fluorine in soil.

The extensive mining of bastnasite (CeFCO) has caused severe pollution of lanthanum (La), cerium (Ce), and fluorine (F) in the surrounding farmland soil, threatening the safety of the soil-plant system. However, the stress effects of the interaction among these three elements on the tolerance and accumulation traits of Brassica chinensis L. (B.

Prediction model for spontaneous combustion temperature of coal based on PSO-XGBoost algorithm.

The construction of a predictive model that accurately reflects the spontaneous combustion temperature of coal in goaf is fundamental to monitoring and early warning systems for thermodynamic disasters, including coal spontaneous combustion and gas explosions. In this paper, on the basis of programming temperature experiment and industrial analysis, 381 data sets of 9 coal types are established, and feature selection was executed through the utilization of the Pearson correlation coefficient, ultimately identifying O, CO, CO, CH, CH, CH/CH, CH/CH, CH/CH, CO/CO, and CO/O as input indicators for the prediction model. The chosen indicator data were divided into training and testing sets in a 4:1 ratio, the Particle Swarm Optimization (PSO) methodology was applied to optimize the parameters of the XGBoost regressor, and a universal PSO-XGBoost prediction model is proposed.

Study on transportation and stress distribution of the overburden rock of gob side entry with cutting top and unloading pressure.

In order to solve the problems of serious deformation and difficult support of roadway surrounding rock in the process of gob-side entry driving, taking 230,708 working face of Huopu Mine as the engineering background, the migration characteristics of overburden rock and the stress distribution of surrounding rock before and after roof cutting in the process of gob-side entry driving were studied by means of theoretical analysis, similar simulation test and field measurement. The results show that: ① the establishment of lateral suspension mechanical model analysis found that, with the increase of coal seam dip angle, the reduction of the coal pillar bearing capacity before and after cutting the top gradually decreases, the dip angle of coal seam is 30°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2164 KN; with the increase of the overburden rock caving angle, the reduction of the coal pillar bearing capacity before and after cutting the top increases continuously, the caving angle of overburden rock is 63°, Compared with the reduction of coal pillar bearing capacity before roof cutting is 2218 KN. ② After the implementation of roof cutting and cutting off the overhanging roof structure, the stress of the surrounding rock of the coal pillar gang in the roadway has significantly decreased by 18.

Using roof borehole electrical resistivity tomography to monitor roof water infiltration in a mine work face.

Roof water inrush in coal mining is a significant type of water-related disaster that usually results from the interconnection of water-bearing geological formations formed by cracks during and after work face mining. Therefore, monitoring roof water infiltration is of paramount importance in preventing or mitigating water inrush in the mine work face. This study employed the roof borehole electrical resistivity tomography method to conduct physical experiments for monitoring water seepage in roof cracks generated during coal model mining.

Study on the evolution law of the 'Butterfly-type' plastic zone in the surrounding rock of deep dynamic pressure roadway.

The formation and development of plastic zone in the surrounding rock is the essence of large deformation damage to the surrounding rock in deep, highly stressed roadway. The -850 m roadway of the Qujiang mine is laid flat longitudinally under the 805 working face and coal pillar, and under the influence of the mining movement of the upper working face and the pre-stressing pressure of the coal pillar, the periphery of the roadway is no longer a pure non-uniform stress field, but a non-uniform stress field with both vertical and horizontal dynamic pressure. Based on the Hoek-Brown strength criterion, the unified strength theory is modified and the nonlinear unified strength theory of rock is established by comprehensively considering the intermediate principal stress, rock properties and rock structure.

The influences of social support expressed from doctors and disclosed from peers on patient decision-making: an analysis from the online health community.

Patients are turning to OHCs to deal with the stresses and complications of infertility. As a stigmatized disease, infertile patients may value informational support and emotional support differently, which is ignored in existing studies. Based on social support theory, this study aims to reveal the role of informational support and emotional support of doctors in infertile patient decision-making.

Numerical investigation of coal pillar damage mechanisms for various width-to-height ratios.

Pillar stability has garnered significant attention owing to the effects of pillars on coal resource recovery rate, coal pillar stability, and coal bump risk. This study examined the roadway stability control principles of conventional and yield coal pillars. The conventional coal pillars were designed as load-bearing structures with a high load-bearing capacity to carry most of the abutment load, while yield coal pillars were designed as buffer structures for transferring rapidly increasing abutment loads to adjacent solid coal ribs by progressive deformation.

Sustainable application of waste gangue mortar in coal mine tunnel support.

With the increase in coal mining depths, soft and fractured roadway surrounding rocks require grouting and a sprayed protective layer for maintenance. Simultaneously, extensive accumulation of coal gangue causes diverse environmental issues. To enhance on-site coal gangue utilization, this study replaced river sand and cement with coal gangue to develop a novel cement-based mortar for supporting coal mine roadways.

Integrated GWAS, BSA-seq, and RNA-seq analyses to identify candidate genes associated with male fertility trait in peach.

Male sterility in peach (Prunus persica L.), characterized by the absence of fertile pollen grains in the anther, is determined by a recessive allele in homozygosis of the major gene located on chromosome 6. Developing tightly linked molecular markers can help identify appropriate peach parents or male-sterile plants for early culling in segregating progenies, thereby increasing breeding efficiency.

An observed "sandwich" framework mediated via sulfate ions as electron shuttle for efficient electro-oxidation of organic pollutants.

"Electro-oxidation processes are effective in treating sulfate-rich organic wastewater. However, this technology development has been hindered by the poor understanding of the role of sulfate ions. This paper reports that high concentration of sulfate ions significantly enhanced the electro-oxidation of organic pollutants.