Antibacterial activity of the structurally novel C-2 amine-substituted analogues based on quinoxaline.

In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from -phenylenediamine. Among them, compounds 5m-5p displayed good to moderate antibacterial activity with MICs of 4-16 μg mL against , 8-32 μg mL against , 8-32 μg mL against MRSA and 4-32 μg mL against , respectively. Compound 5p, identified as a potent broad-spectrum antibacterial agent, demonstrated the strongest inhibitory effects against a range of bacterial strains and low cytotoxicity, thereby warranting further investigation.