Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy.

A synthetic method for preparing a Pluronic F127 (F127)-stabilized graphene (GO) supramolecular hydrogel as a safe nanovehicle for combination treatment has been studied. Doxorubicin (DOX) as a model drug is non-covalently bound on the great surface area of GO due to strong π-π interaction, hydrophobic interaction, and the strongest hydrogen bonding. drug release experiments revealed that this F127-stabilized GO supramolecular hydrogel has a sustained drug release characteristic.