3 results match your criteria: "China National Rodent Laboratory Animal Resources Center[Affiliation]"
Multiplex Detection of SNPs for Genetic Monitoring in Laboratory Mice by Luminex xTAG Assay.
Genes (Basel)
December 2024
China National Rodent Laboratory Animal Resources Center, Beijing 102629, China.
The genetic quality of laboratory mice may have a direct impact on the results of research. Therefore, it is essential to improve genetic monitoring methods to guarantee research quality. However, few current methods boast high efficiency, high throughput, low cost, and general applicability at the same time.
View Article and Find Full Text PDFComparison of TLR4 Genotype and TLR4 Pathway-Related Cytokines in Different Strains of Mice in Response to Pertussis Toxin Challenge.
Genes (Basel)
November 2024
Division of Laboratory Animal Monitoring, National Institutes for Food and Drug Control, Beijing 102629, China.
Article Synopsis
- The study investigates how genetic variations in the TLR4 gene affect immune responses to pertussis toxin in different mouse strains (ICR, NIH, BALB/c).
- Researchers discovered three specific mutations in the TLR4 gene and noted how these variations influence cytokine production in response to stimulation.
- The findings aim to improve the consistency of vaccine evaluations across different mouse models, potentially enhancing vaccine development by standardizing immune response assessments.
Evaluation of acellular pertussis vaccine: comparisons among different strains of mice.
Emerg Microbes Infect
December 2023
Division of Laboratory Animal Monitoring, National Institutes for Food and Drug Control, Beijing, People's Republic of China.
The current study was designed to comparatively analyse the reactions of different mouse strains in response to vaccine, with attempt to further provide a reference for aP vaccine evaluation. NIH mice, ICR mice, and BALB/c mice adopted from different pharmacopoeias and studies were utilized to measure the immune protection and immunogenicity of the same batch of aP vaccine according to the from some Asian pharmacopoeias and the method from European Pharmacopoeia. Based on our results, the aP vaccine detected by NIH mice had the best potency.
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