1,221 results match your criteria: "China National Center for Food Safety Risk Assessment.[Affiliation]"

Association of autosomal mosaic chromosomal alterations with risk of bladder cancer in Chinese adults: a prospective cohort study.

Cell Death Dis

September 2024

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.

Article Synopsis
  • The study explores the link between autosomal mosaic chromosomal alterations (mCAs) and bladder cancer using data from nearly 100,000 participants in the China Kadoorie Biobank who were cancer-free at the start.
  • Researchers found that individuals with autosomal mCAs had a significantly higher risk of developing bladder cancer, with the highest risk associated with mosaic loss events.
  • The results also indicated that lower levels of physical activity increased the cancer risk for those with mCAs, suggesting that physical activity might be a beneficial factor for mCAs carriers to reduce their risk.
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Microbial interactions shaping host attractiveness: insights into dynamic behavioral relationships.

Curr Opin Insect Sci

December 2024

New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China; Institute of Pathogenic Organisms, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China; Southwest United Graduate School, Kunming 650092, China. Electronic address:

Insects discern the presence of hosts (host plants) by integrating chemosensory, gustatory, and visual cues, with olfaction playing a pivotal role in this process. Among these factors, volatile signals produced by host-associated microbial communities significantly affect insect attraction. Microorganisms are widely and abundantly found on the surfaces of humans, plants, and insects.

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Article Synopsis
  • * A new material, MIL-101-SONa, was developed to effectively extract NNIs from environmental samples, utilizing modifications to improve interaction and electrostatic attraction.
  • * The method using MIL-101-SONa demonstrated impressive detection capabilities with low thresholds and high accuracy, successfully identifying NNI levels in various beverages, indicating its potential for practical use in monitoring NNI contamination.
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DNA Methylation Age Mediates Effect of Metabolic Profile on Cardiovascular and General Aging.

Circ Res

October 2024

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (Y.M., C.Y., D.S., Y.P., L. Li, J.L.).

Background: Alterations in lipid metabolism and DNA methylation are 2 hallmarks of aging. Connecting metabolomic, epigenomic, and aging outcomes help unravel the complex mechanisms underlying aging. We aimed to assess whether DNA methylation clocks mediate the association of circulating metabolites with incident atherosclerotic cardiovascular disease (ASCVD) and frailty.

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Food and medicinal substances(FAMS) with both edible and medicinal uses have a long history in China, being an important part of China's excellent traditional culture and traditional Chinese medicine(TCM). The legal management of FAMS is in the form of catalogue, which has a history of nearly 40 years. More than 100 substances have been included in the China's FAMS catalogue.

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The potential contamination, including microbial and mycotoxin infection, may escape from the naked eye, posing great threats to food products. Recently, photodynamic inactivation (PDI)-based technology particular has received particular attention because of their high safety. Herein, food-derived hesperetin (Hst) was innovatively introduced as an esculent photosensitizer, engineering with food-grade TiO nanoparticles (NPs) to form an organic-inorganic heterojunction structure.

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Exposure assessment to areca alkaloids in the Chinese populations through areca nut chewing.

J Food Sci Technol

October 2024

College of Food Science and Nutritional Engineering, National Engineering Research Centre for Fruits and Vegetables Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing, 100083 People's Republic of China.

Article Synopsis
  • Chewing areca nuts is common in China, but the major toxic compounds, areca alkaloids, raise health concerns. !*
  • A study analyzed four areca alkaloids in 119 samples and collected 3030 questionnaires to assess exposure levels among the Chinese population. !*
  • Results showed significant variations in alkaloid content and estimated daily intake, particularly for young males, highlighting the need for public education on the health risks associated with areca nut consumption. !*
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Article Synopsis
  • - Titanium dioxide (TiO) is widely used as a food additive in China, but detailed data on its particle size and dietary exposure is limited.
  • - A study found that 37.7% of TiO particles in food additives are nanoparticles (NPs), with candies (excluding gum) having the highest TiO content; the average dietary exposure for the population was found to be 34.84 μg/kg bw/day for TiO and 3.44 μg/kg bw/day for TiO NPs.
  • - Dietary exposure to TiO NPs varies by age and region, with children and residents of Inner Mongolia showing the highest intake; however, the risk associated with TiO NP exposure is considered acceptable
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Effect of Chlorella pyrenoidosa and Spirulina platensis powder on the physicochemical, structural, and rheological properties of rice starch: A comparative study.

Food Chem

January 2025

College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430048, China; Key Laboratory of the Deep Processing of Bulk Grain and Oil Authorized by Ministry of Education, Wuhan 430000, Hubei, PR China. Electronic address:

The effect of Chlorella pyrenoidosa (CP) and Spirulina platensis (SP) at concentrations of 0 %-12 % on the properties of rice starch (RS) was investigated. Compared with pure RS, the addition of CP and SP powder decreased the viscosity, increased the gelatinization temperature, and promoted the retrogradation of RS gel. However, when CP was added at 12 % and SP at 8 %, retrogradation inhibition was reduced.

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Comprehensive dietary exposure assessment of the Chinese population to organophosphate esters (OPEs): Results of the sixth China total diet study.

Chemosphere

September 2024

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address:

Organophosphate esters (OPEs) are emerging pollutants, while data on their occurrence in foods and human dietary intake are limited. Based on the 6th China total diet study conducted in 2016-2019, this study implemented a comprehensive survey of OPEs in plant-derived foods of cereals, potatoes, legumes, fruits, vegetables, and further assessed dietary exposure from both plant- and animal-derived food. The sum concentrations of 15 OPEs in the plant-derived samples ranged from 0.

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Heterocyclic aromatic amines (HAAs) are harmful byproducts in food heating. Therefore, exploring the prediction and generation patterns of HAAs is of great significance. In this study, genetic algorithm (GA) and support vector regression (SVR) are used to establish a prediction model of HAAs based on heating conditions, reveal the influence of heating temperature and time on the precursor and formation of HAAs in roast beef, and study the formation rules of HAAs under different processing conditions.

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Bioaccessibility and bioavailability assessment of cadmium in rice: In vitro simulators with/without gut microbiota and validation through in vivo mouse and human data.

Sci Total Environ

November 2024

Food Safety and Health Research Center, NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, Guangdong-Hongkong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Public Health, Southern Medical University, Guangzhou 510515, PR China. Electronic address:

Assessing the bioaccessibility and bioavailability of cadmium (Cd) is crucial for effective evaluation of the exposure risk associated with intake of Cd-contaminated rice. However, limited studies have investigated the influence of gut microbiota on these two significant factors. In this study, we utilized in vitro gastrointestinal simulators, specifically the RIVM-M (with human gut microbial communities) and the RIVM model (without gut microbial communities), to determine the bioaccessibility of Cd in rice.

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Aromatic amino acid oxidation products (AAAOPs) are newly discovered risk substances of thermal processes. Due to its significant polarity and trace level in food matrices, there are no efficient pre-treatment methods available to enrich AAAOPs. Herein, we proposed a magnetic cationic covalent organic framework (FeO@EB-iCOF) as an adsorbent for dispersive magnetic solid-phase extraction (DMSPE).

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The Role of Active and Passive Smoking in Chronic Obstructive Pulmonary Disease and Systemic Inflammation: A 12-year Prospective Study in China.

J Epidemiol Glob Health

September 2024

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.

Background: There is no consensus on the cause and effect of systemic chronic inflammation (SCI) regarding chronic obstructive pulmonary disease (COPD). The impact of second-hand smoke (SHS) on COPD has reached inconsistent conclusions.

Methods: The China Kadoorie Biobank cohort was followed up from the 2004-08 baseline survey to 31 December 2018.

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The occurrence and exposure of microplastics in bivalves from Qingdao, China.

Mar Pollut Bull

October 2024

Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou 510515, China; Research Unit of Food Safety, Chinese Academy of Medical Sciences (No. 2019RU014), NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:

This study investigated the regional, seasonal, and species abundance and characteristics of microplastics (MPs) in bivalves from Qingdao, China and assessed the dietary exposure of MPs through bivalve consumption. The average abundance was 1.17 ± 1.

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A Versatile Visual Molecular Imprinting-Driven Switchable Nanozyme Activity-Based Trimodal Assay and Logic Gate Circuits of Ethyl Carbamate.

Anal Chem

September 2024

School of Food & Biological Engineering, Anhui Province Key Laboratory of Agricultural Products Modern Processing, Hefei University of Technology, Hefei 230009, China.

Concerns regarding the hazard of the carcinogenic ethyl carbamate (EC) have driven attempts to exploit efficient, timely, straightforward, and economic assays for warning early food safety. Here, we proposed a novel molecularly imprinted polymer Co@MOF-MIP, with a high peroxidase (POD)-like activity and a bright blue fluorescence emission, to develop a versatile visual assay for colorimetric, fluorescent, and photothermal trimodal detection and logic gate outputting of EC. Briefly, the POD-like activity of Co@MOF-MIP made it to decompose HO into OH for oxidizing colorless 3,3',5,5'-tetramethylbenzidine (TMB) into a blue oxTMB, resulting in a 660 nm irradiated photothermal effect and bursting the blue fluorescence of Co@MOF-MIP via inner filter effect, observing a decreased fluorescence signal together with an increased colorimetric and 660 nm irradiated photothermal signals.

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Article Synopsis
  • * Advances in genomics have revealed the significant role of gut microbiota in jaundice, influencing bilirubin excretion in different ways, with some bacteria enhancing and others impeding bilirubin metabolism.
  • * Understanding the interaction between gut bacteria and bilirubin could lead to better strategies for managing breast milk jaundice and developing new therapeutic approaches to mitigate its effects.
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Background: Whether adherence to a healthy lifestyle is associated with a lower risk of developing pneumonia and a better long-term prognosis remains unclear. This study aimed to investigate associations of individual and combined lifestyle factors (LFs) with the incidence risk and long-term prognosis of pneumonia hospitalization.

Methods: Using data from the China Kadoorie Biobank study, we used the multistate models to investigate the role of five high-risk LFs, including smoking, excessive alcohol drinking, unhealthy dietary habits, physical inactivity, and unhealthy body shape, alone or in combination in the transitions from a generally healthy state at baseline to pneumonia hospitalization or cardiovascular disease (CVD, regarded as a reference outcome), and subsequently to mortality.

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Serum trace elements show association with thyroperoxidase autoantibodies in Thyroid Imaging Reporting and Data System (TI-RADS) 4 nodules.

Sci Rep

August 2024

Healthcare-Associated Infection Control Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 32 West Section 2, 1st Ring Road, Chengdu, 610072, China.

Thyroid nodule (TN) has been becoming a great concern worldwide due to its high incidence. Although some studies have reported associations between trace elements exposure and the risk of TNs, the linkage was not inconclusive. The present study aimed to identify the association of selected serum trace elements (Ca, Mg, V, Fe, Co, Cu, Zn, Se, Mn and Mo) with TNs among general adults.

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Impact of enniatins and beauvericin on lipid metabolism: Insights from a 3D HepaRG spheroid model.

Environ Int

September 2024

Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, Hubei, China; NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100021, China.

Article Synopsis
  • Emerging mycotoxins enniatins (ENNs) and beauvericin (BEA) are potentially harmful to human health through diet, yet there is limited research on their toxicity mechanisms.
  • This study creates a reliable 3D model using HepaRG hepatocytes to analyze how ENNs and BEA affect liver lipid metabolism.
  • Findings show that ENNs and BEA alter lipid metabolism pathways, particularly glycerophospholipids and sphingolipids, and bind strongly to key enzymes, suggesting potential liver toxicity and health risks.
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Article Synopsis
  • Calcium β-hydroxy-β-methylbutyrate (CaHMB) is a nutritional supplement known for promoting muscle growth, preventing muscle loss, and enhancing immunity, frequently used in medical and sports nutrition foods.
  • A new method for accurately detecting CaHMB in these food products has been developed, utilizing solid-phase extraction (SPE) and high-performance liquid chromatography (HPLC) to achieve precise results.
  • The method demonstrated excellent calibration linearity and allowed for successful detection of CaHMB in real products, with results aligning closely to labeled values, showcasing its effectiveness for monitoring CaHMB levels.
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Occurrence and health risk assessment of toxic metals and rare earth elements in microalgae: Insight into potential risk factors in new sustainable food resources.

Food Chem X

October 2024

Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, Hubei, China.

Microalgae are a promising sustainable food source with high nutritional value and environmental benefits. This study investigated the presence of toxic metals and rare earth elements (REEs) in 68 microalgal-based food products and conducted a probabilistic risk assessment to evaluate potential health risks. The findings revealed high detection rates of REEs (80.

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Improving physical stability of microalgae protein-based emulsions under acidic and neutral conditions via carboxymethyl chitosan complexation.

Food Chem X

October 2024

Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, Hubei, China.

The emulsification stability of microalgae protein (MP) is limited to strongly alkaline conditions, restricting its applications in food processing. This study aims to investigate the capability of carboxymethyl chitosan (CMCS) to improve MP's emulsification stability over a wider pH range. Results indicated soluble MP-CMCS complexes formed at pH 2, 4, and 7, while aggregation of the complexes occurred at pH 8.

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Distribution and safety evaluation of deoxynivalenol and its derivatives throughout the wheat product processing chain.

Food Res Int

September 2024

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, China. Electronic address:

Article Synopsis
  • The study examined the distribution of deoxynivalenol (DON) and its derivatives in the wheat processing chain, focusing on how they change from wheat grain to finished products using liquid chromatography-mass spectrometry (LC-MS/MS).
  • Results showed that processing wheat significantly reduced DON levels by 52.7%-68.2%, with biscuit making achieving the highest reduction of 70.6%.
  • Additionally, the research assessed health risks associated with DON exposure in the Chinese population, finding that while there is an acceptable risk overall, infants and young children are the most exposed, suggesting a need for better management of DON levels in wheat products.
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