Simulation analysis of 35 MeV high-power electron accelerator driven white neutron source target.

The white neutron source driven by an electron accelerator utilizes a pulsed electron beam to bombard a target, producing neutrons through photoneutron reactions. The white neutron source of photoneutron reaction has advantages such as compact structure, low cost, capability of generating ultra-short pulse, and wide applications in the resonance energy region, effectively complementing reactor neutron sources and spallation neutron sources. The development of high-current, high-power electron accelerator-driven white neutron sources is of significant importance for neutron science research and nuclear technology applications.

Spatial and temporal distribution and ecological risk assessment of typical antibiotics in natural and wastewater of Jinjiang River Basin.

Antibiotics are widely used in human medical, livestock, and aquaculture fields. Most antibiotics are water-soluble and cannot be fully absorbed by humans or animals. If feces or wastewater containing antibiotics are improperly treated or discharged directly into surface water or groundwater, it will undoubtedly have an impact on aquatic organisms.

Geochemical Evidence of Ore-Forming Processes in the Shuiyindong Gold Deposit of Southwest Guizhou Province, China.

The Shuiyindong deposit is one of the ultralarge Carlin-type gold deposits in Southwest Guizhou Province, China. Gold mineralization mainly occurs in the Permian Longtan Formation and the early Triassic Yelang Formation. It is controlled by both strata and faults.

Development of sequential online extraction electrospray ionization mass spectrometry for accurate authentication of highly-similar Atractylodis Macrocephalae.

The accurate and rapid authentication techniques and strategies for highly-similar foods are still lacking. Herein, a novel sequential online extraction electrospray ionization mass spectrometry (S-oEESI-MS) was developed to achieve spatio-temporally resolved ionization and comprehensive characterization of complex foods with multi-components (high, medium, and low polarity substances). Meanwhile, a characteristic marker screening method and an integrated research strategy based on MS fingerprinting, characteristic marker and chemometrics modeling were established, which are especially suitable for the accurate and rapid authentication of highly-similar foods that are difficult to be authenticated by traditional techniques (e.

First-Principle Studies on Local Lattice Distortions and Thermodynamic Properties in Non-Stoichiometric Thorium Monocarbide.

Thorium monocarbide (ThC) is interesting as an alternative fertile material to be used in nuclear breeder systems and thorium molten salt reactors because of its high thermal conductivity, good irradiation performance, and wide homogeneous composition range. Here, the influence of carbon vacancy site and concentration on lattice distortions in non-stoichiometric ThC ( = 0, 0.03125, 0.

Sensitive quantitation of ultra-trace toxic aconitines in complex matrices by perfusion nano-electrospray ionization mass spectrometry combined with gas-liquid microextraction.

The accurate analysis of ultra-trace (e.g. <10 ng/mL) substances in complex matrices is a burdensome but vital problem in pharmaceutical analysis, with important implications for precise quality control of drugs, discovery of innovative medicines and elucidation of pharmacological mechanisms.

Synthesis and fabrication of segregative and durable MnO@chitosan composite aerogel beads for uranium(VI) removal from wastewater.

To address the imperative need for efficient removal of uranium-containing wastewater and mitigate radioactive contamination risks associated with nuclear energy, the development of materials with high removal efficiency and facile separation is crucial. This study designed and synthesised MnO@chitosan (CTS) composite aerogel beads by in-situ growing δ-MnO on porous CTS aerogel beads. This approach not only mitigates the agglomeration of MnO nanospheres but also significantly enhances the porous structure and surface area of MnO@CTS.

Flexible self-supporting NaMnTi(PO)@C fibers for uranium extraction from seawater by electro sorption.

As an eco-friendly technique with the superior adsorption performance, electroadsorption has shown great potential for application in uranium (U(VI)) recovery in recent years. However, the electrodes used in the electrosorption generally suffer the adsorbent to be loaded on the conductors, which greatly limited the adsorption performance of the electrodes for uranyl ions. In present study, a flexible self-supporting NaMnTi(PO)@C fibers (NMTP@C fibers) electrode material was rationally designed and prepared by electrostatic spinning method and annealing technique, and its ability to capture U(VI) efficiently was preliminarily demonstrated by batch adsorption and electro sorption.

Rapid authentication of different herbal medicines by heating online extraction electrospray ionization mass spectrometry.

The rapid and accurate authentication of traditional Chinese medicines (TCMs) has always been a key scientific and technical problem in the field of pharmaceutical analysis. Herein, a novel heating online extraction electrospray ionization mass spectrometry (H-oEESI-MS) was developed for the rapid and direct analysis of extremely complex substances without the requirement for any sample pretreatment or pre-separation steps. The overall molecular profile and fragment structure features of various herbal medicines could be completely captured within 10-15 s, with minimal sample (<0.

Electrosorption performance on graphene-based materials: a review.

Due to its unique advantages such as flexible planar structure, ultrahigh specific surface area, superior electrical conductivity and electrical double-layer capacitance in theory, graphene has unparalleled virtues compared with other carbon materials. This review summarizes the recent research progress of various graphene-based electrodes on ion electrosorption fields, especially for water desalination utilizing capacitive deionization (CDI) technology. We present the latest advances of graphene-based electrodes, such as 3D graphene, graphene/metal oxide (MO) composites, graphene/carbon composites, heteroatom-doped graphene and graphene/polymer composites.

Online discovery of the molecular mechanism for directionally detoxification of Fuzi using real-time extractive electrospray ionization mass spectrometry.

Ethnopharmacological Relevance: Aconitum carmichaelii Debeaux, a famous traditional medicinal herb for collapse, rheumatic fever, and painful joints, always raises global concerns about its fatal toxicity from toxic alkaloids when improperly processed. Therefore, it is urgent to clarify the internal molecular mechanism of processing detoxification on Aconitum and develop simple and reliable approaches for clinical application, which is also of great significance to the rational medicinal use of Aconitum.

Aim Of The Study: The study aimed at developing a complete molecular mechanism exploration strategy in complex medicinal herb decocting system, clarifying the internal molecular mechanism of processing detoxification on Aconitum, and exploring valid approaches for detoxification.

Quality tracing evaluation strategies of compatible materials in Aconitum proprietary Chinese medicines.

The proprietary Chinese medicine (PCM) has become a significant supplement of modern medicine. Nevertheless, the absence of quality control standard of compatible materials in PCM has led to serious adulteration, which has an extremely bad effect on safety of drug use and clinical efficacy. Here, a quality tracing evaluation strategy of compatible materials in 32 Aconitum proprietary Chinese medicines (APCMs) was established, including data normalization, model development, model verification, and unknown prescription cracking.

Limitation standard of toxic aconitines in proprietary Chinese medicines using on-line extraction electrospray ionization mass spectrometry.

Development of rapid analytical methods and establishment of toxic component limitation standards are of great importance in quality control of traditional Chinese medicine. Herein, an on-line extraction electrospray ionization mass spectrometry (oEESI-MS) coupled with a novel whole process integral quantification strategy was developed and applied to direct determination of nine key aconitine-type alkaloids in 20 proprietary Chinese medicines (APCMs). Multi-type dosage forms (, tablets, capsules, pills, granules, and liquid preparation) of APCM could be determined directly with excellent versatility.

Magnetotelluric evidence for the multi-microcontinental composition of eastern South China and its tectonic evolution.

The tectonic boundaries and geodynamic evolution of the South China Block are widely debated. While the community largely agrees on the occurrence of the collision between the Yangtze and Cathaysia Blocks, the lack of ultrahigh-pressure metamorphic rocks and obscurity of the boundary lead to inconsistencies among the abundant geological and geophysical data. We present three profiles that reveal the geoelectrical structure of eastern South China.

[Evaluation and analysis of high-quality products of Liuwei Dihuang Pills].

Liuwei Dihuang Pills is a typical traditional Chinese medicine with "the same product made by many manufacturers". The quality and price of products made in various factories was different obviously. In this study, the quality differences of Liuwei Dihuang Pills were evaluated over multi-dimensions and throughout the whole production cycle involving raw materials, production process, quality control and post-marketing re-studies based on the "Chinese patent medicine evaluation standard with quality at the core" established earlier by our research group.

Rare Three-Dimensional Uranyl-Biphenyl-3,3'-disulfonyl-4,4'-dicarboxylate Frameworks: Crystal Structures, Proton Conductivity, and Luminescence.

Due to the intrinsic coordination preference of the linear uranyl unit, uranyl-organic frameworks (UOFs) are generally prone to exhibiting low-dimensional structures. Reactions of uranyl nitrate with biphenyl-3,3'-disulfonyl-4,4'-dicarboxylic acid dipotassium salt (KHBPDSDC) under different conditions led to three UOFs, namely, {(MeNH)[K(UO)(μ-O)(μ-OH)(μ-OH)(BPDSDC)(HO)]·4DMF} (), {[K(UO)(μ-O)(BPDSDC)(HO)]} (), and {(MeNH)[K(UO)(BPDSDC)(HO)]} (). Compounds and contain one-dimensional (1D) ribbon structures formed from UO units bridged by μ-O atoms and carboxylate groups.

Rhodamine B derivative-modified up-conversion nanoparticle probes based on fluorescence resonance energy transfer (FRET) for the solid-based detection of copper ions.

Herein, a novel solid-based up-conversion fluorescence resonance energy transfer (FRET) sensor was developed using rhodamine B hydrazide, which provided a selective fluorescence response and suitable affinity towards Cu ions over other biologically relevant metal ions because the Cu ion could promote the hydrolysis of α-amino acid esters of rhodamine B hydrazide and yield the Cu·α-amino acid chelate. This solid-based detection system is more convenient for the detection of Cu based on color change and emission spectra instead of the complicated and tedious measurements than other up-conversion sensors and up-conversion luminescent nanoparticles used as an excitation source; moreover, the proposed system shows high selectivity, minimum photo-damage to living organisms, and high chemical stability.

Profiles of volatile indole emitted by Escherichia coli based on CDI-MS.

Escherichia coli is an important pathogen of nosocomial infection in clinical research, Thus, exploring new methods for the rapid detection of this pathogen is urgent. We reported the early release of molecular volatile indole vapour of E. coli cultures and blood cultures analyzed by direct atmospheric corona discharge ionization mass spectrometry (CDI-MS).

Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates.

Flavonoids represent an important class of natural products with a central role in plant physiology and human health. Their accurate annotation using untargeted mass spectrometry analysis still relies on differentiating similar chemical scaffolds through spectral matching to reference library spectra. In this work, we combined molecular network analysis with rules for fragment reactions and chemotaxonomy to enhance the annotation of similar flavonoid glyconjugates.

An ingenious one-dimensional zirconium phosphonate with efficient strontium exchange capability and moderate proton conductivity.

A new 1-D zirconium phosphonate [(CH3)2NH2]2[Zr(CH2(HPO3)(PO3))2] (SZ-5) was synthesized via a solvothermal reaction and its single crystal structure was elucidated. SZ-5 exhibits efficient strontium exchange capability with high uptake capacity and selectivity, as further demonstrated by the radioactive Sr-90 removal from a real contaminated seawater sample with an extremely high ionic strength. In addition, the measured proton conductivity at 90 °C and 90% relative humidity (RH) is 5.

The peptide lycosin-I attenuates TNF-α-induced inflammation in human umbilical vein endothelial cells via IκB/NF-κB signaling pathway.

Objective: The peptide lycosin-I has anti-bacterial and anti-cancer capacities. However, the anti-inflammatory activity of lycosin-I remains unknown. We investigated whether lycosin-I could attenuate inflammation.

Fate of estrogens in a pilot-scale step-feed anoxic/oxic wastewater treatment system controlling by nitrogen and phosphorus removal.

The control measures for estrogens in the aquatic environment are topics of growing concern. It is a meaningful issue to finding optimal process parameters for efficient removal of estrogens with the purpose of efficient total nitrogen (TN) or total phosphorus (TP) removal in sewage treatment plants. The present paper is concerned with the relationships between the estrogen removal and TN or TP removal in a pilot-scale three-stage anoxic/oxic (A/O) system treating real municipal wastewater.

Vasodilator and hypotensive effects of the spider peptide Lycosin-I in vitro and in vivo.

Lycosin-I, a spider peptide isolated from the venom of the spider Lycosa singoriensis, has anti-bacteria and anti-cancer properties in organisms. However, cardiovascular effects of Lycosin-I have not been studied. In this study, we investigated for the first time the vasodilator and hypotensive effects of Lycosin-I and the possible mechanisms, in order to develop a promising treatment for hypertension-related diseases.