Predicting the risk of malaria importation into Jiangsu Province, China: a modeling study.

Background: The World Health Organization certified China malaria-free in 2021. Consequently, preventing the risk of malaria re-introduction caused by imported malaria has now become a major challenge. This study aims to characterize the dynamics and predict the risk of malaria importation in Jiangsu Province, where the number of imported malaria cases ranks among the highest in China.

Biomimetic Materials to Fabricate Artificial Cells.

As the foundation of life, a cell is generally considered an advanced microreactor with a complicated structure and function. Undeniably, this fascinating complexity motivates scientists to try to extricate themselves from natural living matter and work toward rebuilding artificial cells . Driven by synthetic biology and bionic technology, the research of artificial cells has gradually become a subclass.

A Comprehensive Evaluation of the HPV Neutralizing Antibodies in Guangzhou, China: A Comparative Study on Various HPV Vaccines.

Background: The evaluation of HPV vaccine effectiveness is essential for informing public health strategies, yet there remains a gap in understanding humoral immune responses generated by different HPV vaccine formulations in regional populations. This study addresses this gap by evaluating the immunogenicity of the newly developed HPV vaccine Cecolin (Wantai), alongside various imported vaccines, including bivalent, quadrivalent, and nonavalent options available in China.

Methods: From March 2023 to June 2024, a total of 352 participants were enrolled, including 87 females aged 9-14 years who received two doses of the bivalent HPV vaccine (Cecolin), 215 females aged 15-45 years who were fully vaccinated with various HPV vaccines, and 50 non-recipients.

Impact on Ant Communities by Chemical Pesticides Applied in Controlling the Red Imported Fire Ant ( Buren) in the Field.

The red imported fire ant (RIFA, Buren) represents a significant invasive pest in China, exerting extensive negative impacts on ecosystems. The invasion of RIFA not only poses a severe threat to biodiversity within the environment; inappropriate controlling measures can also adversely affect community dynamics. Therefore, while implementing effective management strategies to control the proliferation of RIFA populations, it is imperative to evaluate the potential effects of these measures on the structure of local biological communities to safeguard native biodiversity.

Microbubble-based fabrication of resilient porous ionogels for high-sensitivity pressure sensors.

High-sensitivity flexible pressure sensors have obtained extensive attention because of their expanding applications in e-skins and wearable medical devices for various disease diagnoses. As the representative candidate for these sensors, the iontronic microstructure has been widely proven to enhance sensation behaviors such as the sensitivity and limits of detection. However, the fast and tunable fabrication of ionic-porous sensing elastomers remains challenging because of the current template-dissolved or 3D printing methods.

Iron and Inflammatory Cytokines Synergistically Induce Colonic Epithelial Cell Ferroptosis in Colitis.

Inflammatory bowel disease (IBD) is an inflammatory disease that occurs to the intestinal tract. Many patients with IBD often develop anemia and often receive oral iron supplementation. Many of them develop non-compliance with oral iron therapy, but the mechanisms are not well understood.

Virome of red imported fire ants by metagenomic analysis in Guangdong, southern China.

The red imported fire ant (RIFA) has made China its habitat for approximately 25 years, but few reports have described the species and amount of virus circulating in it. Researchers are currently exploring viruses associated with RIFAs as potential biological control agents against invasive ants. The present meta-transcriptome analysis revealed the virome of red imported fire ants in Guangdong, southern China, which included 17 viruses, including virus 4-GD (SINV-4) and Guangdong Polycipiviridae ant virus 1 (GPAV1) in the family; virus 1-GD (SINV-1), and Guangdong Dicistroviridae ant virus 2-3 (GDAV2-3) in the family; Guangdong Iflaviridae ant virus 4-9 (GIAV4-9) in the family; Guangdong Parvoviridae ant virus 10 (GPAV10) in the family; and Guangdong ant virus 11-15 (GAV11-15).

Orbital computed tomography imaging characteristics of thyroid-associated ophthalmopathy.

This study aims to investigate the distribution characteristics and correlations of orbital soft tissue volume expansion in patients with thyroid-associated ophthalmopathy (TAO) by analyzing orbital computed tomography (CT) data and to determine the most appropriate parameters and corresponding cut-off values for imaging classification. Patients with TAO who met the inclusion and exclusion criteria, along with those with lacrimal duct obstruction requiring orbital CT examination, were included in the study. Raw CT data were imported into Mimics and RadiAnt software for analysis, and measurements of orbital volume, orbital fat volume, extraocular muscle volume, optic nerve volume, and exophthalmos were obtained.

A Binational Sample-Initiated Retrospective Outbreak Investigation of Listeria monocytogenes Infections in the United States and Canada Linked to Enoki Mushrooms Imported from China 2022-2023.

In 2022, the U.S. Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), U.

Comparative effectiveness and safety of imported and domestic immune checkpoint inhibitors in China: A systematic review and pairwise and network meta-analyses.

Background: Multiple brands of immune checkpoint inhibitors (ICIs), including domestic and imported agents, have been approved as front-line therapy in China. However, little is known about the difference in efficacy and safety of these agents of different origins. This study aims to systematically compare the difference between National Medical Products Administration (NMPA) approved domestic and imported ICIs regarding their efficacy, safety, and price.

Real-Time Gait Intention Recognition for Active Control of Unilateral Knee Exoskeleton.

Real-time gait estimation is important for the synchrony control of robotic exoskeleton to provide walking assistance. However, for stroke patients with hemiplegic paralysis, the gait pattern is very complex. Accurate and timely gait intention recognition is therefore difficult.

TMCO1 regulates energy metabolism and mitochondrial function of hepatocellular carcinoma cells through TOMM20, affecting the growth of subcutaneous graft tumors and infiltration of CAFs.

This study mainly shows the role of endoplasmic reticulum transmembrane and coiled coil domains 1 (TMCO1) in the regulatory mechanism of hepatocellular carcinoma (HCC). Invasion and migration capacity were detected by Transwell and wound healing after TMCO1 and TOMM20 overexpression and knockdown, and mitochondrial function was detected through reactive oxygen species (ROS), mitochondrial permeability transition pore (mPTP), mitochondrial membrane potential (MMP), and ATP production. A model of subcutaneous tumor formation in nude mice was established to detect the effect of TMCO1 on tumor formation.

Exploring the potential anti-diabetic peripheral neuropathy mechanisms of Huangqi Guizhi Wuwu Decoction by network pharmacology and molecular docking.

Diabetic peripheral neuropathy (DPN) is the most prevalent microvascular complication of diabetes and Huangqi Guizhi Wuwu Decoction (HGWD) is frequently employed in classical Chinese medicine for treating DPN. This study aims to investigate the potential therapeutic targets and mechanisms of HGWD for treating DPN using network pharmacology and molecular docking methodologies. The intersection targets of DPN and HGWD were retrieved from the databases, with the resulting intersection targets being imported into the STRING database to construct the protein-protein interaction (PPI) network.

LDC000067, a CDK9 inhibitor, unveils promising results in suppressing influenza virus infections and .

Influenza virus infections continue to pose a significant threat to public health. Current anti-influenza drugs target viral proteins; however, the emergence of resistant strains has hampered their effectiveness. Fortunately, as with most viruses, influenza virus depends on various host factors during its replication cycle and in pathogenicity.

The 100 most-cited articles in hypothermic brain protection journals: a bibliometric and visualized analysis.

Introduction: A bibliometric analysis is used to assess the impact of research in a particular field. However, a specialized bibliometric analysis focused on hypothermic brain protection has not yet been conducted. This study aimed to identify the 100 most-cited articles published in the field of hypothermic brain protection and analyze their bibliometric characteristics.

History and genetic diversity of African sheep: Contrasting phenotypic and genomic diversity.

Domesticated sheep have adapted to contrasting and extreme environments and continue to play important roles in local community-based economies throughout Africa. Here we review the Neolithic migrations of thin-tailed sheep and the later introductions of fat-tailed sheep into eastern Africa. According to contemporary pictorial evidence, the latter occurred in Egypt not before the Ptolemaic period (305-25 BCE).

A Proposed Coupling Framework of Biological Invasions: Quantifying the Management Prioritization in Mealybugs Invasion.

Prioritizing potential invasive alien species, introduction pathways, and likely places susceptible to biological invasions is collectively critical for developing the targeting of management strategies at pre-border, border, and post-border. A framework for prioritizing the invasion management that considered all these elements in combination is lacking, particularly in the context of potential coinvasion scenarios of multispecies. Here, for the first time, we have constructed a coupling framework of biological invasions to evaluate and prioritize multiple invasion risks of 35 invasive alien mealybugs (IAMs) that posed a significant threat to the agri-horticultural crops in China.

Factors affecting carbon dioxide emissions for sustainable development goals - New insights into six asian developed countries.

The worldwide economic scene faces the dual challenges of rising sea levels and escalating carbon dioxide (CO2) emissions. Environmental contamination impedes sustainable growth, increasing the demand for sustainable energy resources as a fundamental aspect of sustainable economies. The present research uses an analytical model to examine the elements influencing carbon dioxide output in six economically developed Asian nations, intending to assist in realizing the UNSDG- United Nations' Sustainable Development Goals.

Application of an Integrated Risk Matrix and the Borda Count Method on Lassa Fever in Assessing the Importation Risk of EID - 9 African Countries, 1996-2023.

Introduction: Common methods for assessing and responding to outbreaks of emerging infectious diseases (EIDs) are usually applied in isolation and have limitations. This study aimed to integrate the risk matrix and Borda count methods to assess the importation risk of EIDs to China, using Lassa fever (LF) as an example.

Methods: This study used a mixed-methods approach combining multi-source data with an integrated risk matrix and Borda count method.

A novel method to judge the safe position of C2 lamina screw with double holes.

Background: To evaluate the feasibility of C2 laminar screw (C2LS) fixation assisted by double holes and to explore a novel method for judging its safe positioning.

Methods: The Digital Imaging in Communications format data of 25 C2 vertebrae specimens were obtained by computed tomography thin-slice scanning, and the data were imported into Mimics software for three-dimensional reconstruction. The bone cortex was removed at the starting and terminal midpoints of the lamina as the observation holes.

Effect of Nutrition Education During Pregnancy on Iron-Folic Acid Supplementation Compliance and Anemia in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.

Context: Stakeholders implement nutrition education to prevent and control anemia during pregnancy. Nutrition education during pregnancy can increase the consumption of iron-folic acid (IFA) supplements and encourage behavioral changes. However, there is no comprehensive meta-analysis to determine the effectiveness of this intervention.