Optimization for container truck routing in container terminal with multi quay cranes considering emissions policy.

In container terminal, the container trucks should go by a "quay crane - container trucks -import and export block" routing, and the optimization of this routing has become the focus of this paper. This study divided the problem of routing optimization into two levels: one is a routing optimization model of single container truck which takes the lowest total cost as the target, without considering the distribution of overall transportation task; the other is a routing optimization model concerning the allocation of no-load trucks, aiming at the lowest cost of transportation task. We designed an improved Particle Swarm Optimization (PSO) algorithm to solve the two-level optimization model, and the influence of emission policy on the two-level optimization model and the influence of the number of container trucks on the transportation distance of level II in optimization model are analyzed.

Network Pharmacology and Experimental Verification: SanQi-DanShen Treats Coronary Heart Disease by Inhibiting the PI3K/AKT Signaling Pathway.

Objective: To employee network pharmacology to predict the components and pathways of SanQi-DanShen (SQDS) in treating coronary heart disease, followed by in vitro experiments to validate the molecular mechanism of SQDS in treating coronary heart disease.

Methods: We sourced the active ingredients and targets of Panax notoginseng and Danshen from the Traditional Chinese Medicine Systems Pharmacology database. Coronary heart disease related genes were retrieved from the OMIM, Genecards, and Therapeutic Target databases.

Foreign waste ban and green development of Chinese manufacturing industry: Comprehensive evidence based on provincial data.

Since the reform and opening up, imported solid wastes have pushed China's economic growth while also bringing about serious environmental problems. In this context, China has introduced a ban on "foreign waste" for imported solid waste. Based on the provincial panel data from 2010 to 2020, this paper calculates the Green Total Factor Productivity (GTFP) of the manufacturing industry to measure the level of green development of the manufacturing sector, and evaluates the comprehensive impact of the "foreign waste" ban on the green development of the manufacturing industry by using the continuous Difference-in-Differences method.

Enhanced remediation of real agricultural runoff in surface-flow constructed wetlands by coupling composite substrate-packed bio-balls, submerged plants and functional bacteria: Performance and mechanisms.

Import of agricultural runoff containing nutrients considerably contributes to eutrophication of receiving water bodies. Surface-flow constructed wetlands (SFCWs) are commonly applied for agricultural runoff purification, but the performance is usually unsatisfactory. In this study, suspended bio-balls filled with zeolite and iron-carbon (Fe-C) composite substrates, submerged macrophyte (Ceratophyllum demersum) and functional denitrifying bacteria were collectively added into SFCW microcosms to enhance the remediation efficiency for real agricultural runoff with high nutrient concentrations and low content of bioavailable organic matter.

Bipartite nuclear localization sequence is indispensable for nuclear import and stability of self-dimerization of ADARa in Bombyx mori.

The conservative post-transcriptional modification in mammals and Drosophila is adenosine-to-inosine (A-to-I) deamination in double-stranded RNA, catalyzed by RNA-editing enzymes known as adenosine deaminases acting on RNA (ADARs). The traditional nuclear import pathway for ADARs involves the recognition of a putative classical nuclear localization sequence (NLS) by importin α4 and α5. In our previous research, ADAR in silkworm, Bombyx mori (BmADARa) was confirmed predominantly located in the nucleus.

Improving the growth and intestinal colonization of Escherichia coli Nissle 1917 by strengthening its oligopeptides importation ability.

Escherichia coli Nissle 1917 (EcN), the probiotic featured with well-established safety in different host, is emerging as a favored chassis for the construction of engineered probiotics for disease treatment. However, limited by the low intestinal colonization ability of EcN, repeated administration is required to maximize the health benefits of the EcN-derived engineered probiotics. Here, using fecal metabolites as "metabolites pool", we developed a metabolomic strategy to characterize the comprehensive metabolic profile of EcN.

Enhancement of single-atom catalytic activity by the synergistic effect of interlayer charge transfer and magnetic coupling in an electride-based heterostructure.

2D material-based single-atom catalysts have rapidly emerged and flourished in recent years due to their exceptional atomic utilization efficiency, adjustable catalytic activity, and remarkably high selectivity. The interface matching mechanism of 2D materials, influenced by van der Waals (vdW) interactions, presents a novel opportunity for constructing a heterostructure, further augmenting catalytic efficiency. In this work, the mechanism of performance regulation of magnetic transition-metal decorated MoS single-atom catalysis by importing a GdC electride substrate is investigated using first-principles calculations.

Office-Based Digital Workflow for Managing Old Mandibular Fracture Malunion: Use of Short-Segment Drilling and Osteotomy Guides With Predictive Holes.

Treating old mandibular fractures with malunion is challenging due to the need for osteotomy and interference between bone segments, complicating occlusal restoration. This technical note introduces a novel office-based digital workflow utilizing surgical guides. Preoperative computed tomography (CT) data were imported into MIMICS software for virtual surgical planning to precisely realign bone fragments based on anatomical and occlusal relationships.

ATP-binding cassette transporter TaABCG2 contributes to Fusarium head blight resistance by mediating salicylic acid transport in wheat.

ATP-binding cassette (ABC) transporters hydrolyse ATP to transport various substrates. Previous studies have shown that ABC transporters are responsible for transporting plant hormones and heavy metals, thus contributing to plant immunity. Herein, we identified a wheat G-type ABC transporter, TaABCG2-5B, that responds to salicylic acid (SA) treatment and is induced by Fusarium graminearum, the primary pathogen causing Fusarium head blight (FHB).

The optimal spatially-dependent control measures to effectively and economically eliminate emerging infectious diseases.

Non-pharmaceutical interventions (NPIs) are effective in mitigating infections during the early stages of an infectious disease outbreak. However, these measures incur significant economic and livelihood costs. To address this, we developed an optimal control framework aimed at identifying strategies that minimize such costs while ensuring full control of a cross-regional outbreak of emerging infectious diseases.

Targeted opportunities to mitigate water scarcity, inequality, and inequity embedded in international food trade for vulnerable countries.

International food trade reshapes regional water scarcity through virtual water transfers (VWT), influencing water use equality and equity. This study examines eight populous yet impoverished countries in Africa and Asia, representing 30 % of the global poor population and contributing 20 % to agricultural VWT. Despite their significant role, these countries have been understudied due to a lack of data or attention.

Mechanisms and therapeutic potential of disulphidptosis in cancer.

SLC7A11 plays a pivotal role in tumour development by facilitating cystine import to enhance glutathione synthesis and counteract oxidative stress. Disulphidptosis, an emerging form of cell death observed in cells with high expression of SLC7A11 under glucose deprivation, is regulated through reduction-oxidation reactions and disulphide bond formation. This process leads to contraction and collapse of the F-actin cytoskeleton from the plasma membrane, ultimately resulting in cellular demise.

Mitigating harmful cyanobacterial blooms in drinking water reservoirs through in-situ sediment resuspension.

Mitigating harmful cyanobacterial blooms is a global challenge, particularly crucial for safeguarding source water. Given the limitations of current technologies for application in drinking water reservoirs, we propose an innovative strategy based on in-situ sediment resuspension (SR). This method's effectiveness in cyanobacterial control and its potential impacts on water quality were assessed through laboratory culture experiments and further validated via field applications in five drinking water reservoirs.