A UAV path planning method based on the framework of multi-objective jellyfish search algorithm.

Multi-constraint UAV path planning problems can be viewed as many-objective optimization problems that can be solved by meta-heuristic algorithms with good self-organizing optimization capabilities. However, such algorithms mostly use random initializing methods, resulting in low-quality initial paths that reduce the efficiency of subsequent algorithmic searches. Moreover, as the number of objective functions increases, meta-heuristic algorithms face inadequate selection pressure and convergence capability, which lead to poor solution.

Exploring the mechanism of tetramethylpyrazine in the treatment of osteoarthritis based on network pharmacology.

Background: Osteoarthritis (OA) is the most common joint disease, which mainly damages articular cartilage and involves the whole joint tissue. It has the characteristics of long course, repeated symptoms and high disability rate, and the incidence trend is gradually increasing. Tetramethylpyrazine (TMP) is the main alkaloid active substance in Ligusticum wallichii, a traditional Chinese medicine, which has the effect of promoting blood circulation and dredging collaterals, and has a good effect on the treatment of early OA, but its molecular mechanism has not been fully clarified so far.

Does import trade liberalization worsen residents' health? Evidence from China.

Health is important to human capital and national sustainable development. Based on the latest Chinese Family Panel Studies (CFPS), this paper uses the IVprobit model to test the impact of import trade liberalization on residents' health from the micro-individual perspective and further explores its mechanism. The results indicate that import trade liberalization brings hidden health costs, and that the negative effects on the health of people in eastern China or rural areas, people with a low education background, people under 60 years of age, and women are more significant.

Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies.

Targeting cellular senescence, one of the hallmarks of aging and aging-related pathologies emerges as an effective strategy for anti-aging and cancer chemotherapy. Here, a switch from TBK1-OPTN axis to TBK1-ATAD3A axis to promote cellular senescence is shown. Mechanically, TBK1 protein is abnormally activated and localized to the mitochondria during senescence, which directly phosphorylates ATAD3A at Ser321.

Effects of Postharvest SO Treatment on Longan Aril Flavor and Glucosinolate Metabolites.

SO fumigation treatment (commonly known as sulfur treatment, ST) is a key method in the postharvest preservation of imported and exported fresh longan fruits, effectively reducing pericarp browning and enhancing color. Nonetheless, distinctive aromas, often referred to as "sulfur flavor", may develop in the aril during the extended preservation period. This study employed "Caopu" longan as the test material and patented SO-releasing paper (ZL201610227848.

China's International Trade of Parrots from 1981 to 2022 Based on the CITES Trade Database.

Parrots are popular with pet consumers and are one of the most traded groups of live birds around the world. China has been considered as an important country in bird trades, but we know little about China's import and export of parrots. Using the latest data available from the CITES Trade Database, we analyzed China's import and export of CITES-listed live parrots from 1981-2022 to better understand the patterns and dynamics of these trades.

Agricultural trade liberalization, governance quality, and technical efficiency in the agricultural sector of Southeast Asia.

International trade has been regarded as an essential factor in enhancing a country's productivity and efficiency. Nevertheless, developing countries squander money and resources as a result of their deficient institutional quality, impeding their ability to profit from specialization and trade. Therefore, this study intends to investigate the impact of agricultural trade liberalization and governance quality on technical efficiency in Southeast Asia's agricultural sector using balanced panel data spanning from 2002 to 2021.

The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.

RNA-binding proteins (RBPs) play critical roles in tumor progression by participating in the posttranscriptional regulation of RNA. However, the levels and function of RBPs in nasopharyngeal carcinoma (NPC) remain elusive. Here we identified a noncanonical RBP RAN that has the most significant role in NPC progression by a small siRNA pool screening.

Simulation study on heavy metals, phthalate esters, and organic halogens: Content and distribution characteristics during waste paper recycling.

Imported waste paper and recycled pulp may contain pollutants, posing potential environmental risks to the ecosystem of China. This study examined the presence and distribution patterns of heavy metals, phthalate esters (PAEs), and adsorbable organic halogens (AOX) in recycled pulp and production wastewater after various recycling processes of three typical restricted types of imported waste paper. The results indicated that the concentration ranges of heavy metals, PAEs, and AOX in the three types of imported recycled waste paper were 21.

Pulmonary coccidioidomycosis in China: Case reports and literature review.

Coccidioidomycosis is a fungal infection commonly found in the tropical regions of southwestern United States, such as Arizona, the Central Valley of California, parts of New Mexico, and western Texas. The endemic regions also extend into northern Mexico and include focal endemic areas in sections of Central America and Argentina. Coccidioides species have also been reported in central and southern Utah, Nevada, and the central part of Washington State.

Comparative study on slaughter performance, meat quality, and rumen microbiota of Hainan Dong goat and its hybrid with Nubian goat.

Introduction: The Hainan Dong goat (DG) is a local meat breed widely raised in Hainan, China because of its good adaptability to local hot and humid weather. However, the growth rate of these DG is much slower than that of commercialised breeds improved in European countries, resulting in poor carcase characteristics, including smaller slaughter weight and carcase weight, which have become increasingly prominent. In recent decades, Nubian goats have been continuously imported into China to improve the production performance of local breeds.

Analysis of mitochondrial protein translocation by disulfide bond formation and cysteine specific crosslinking.

Protein translocation is a highly dynamic process and, in addition, mitochondrial protein import is especially complicated as the majority of nuclear encoded precursor proteins must engage with multiple translocases before they are assembled in the correct mitochondrial subcompartment. In this chapter, we describe assays for engineered disulfide bond formation and cysteine specific crosslinking to analyze the rearrangement of translocase subunits or to probe protein-protein interactions between precursor proteins and translocase subunits. Such assays were used to characterize the translocase of the outer membrane, the presequence translocase of the inner membrane and the sorting and assembly machinery for the biogenesis of β-Barrel proteins.

Determination of sulfonamide antibiotics in forage grasses by an improved QuEChERS and multi-plug filtration cleanup method combined with UHPLC-MS/MS.

An improved QuEChERS method combined with Multi-Plug Filtration Cleanup (m-PFC) clean-up procedure was developed for the simultaneous determination of 16 different sulfonamides in forage grasses using ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). The forage grass sample was extracted with 0.1 mol L NaEDTA-Mcllvaine buffer and acetonitrile solution, purified by the Navo U-QuE column tube, separated by Agilent ZORBAX Eclipse Plus C column, and analyzed by MRM (multiple reaction monitoring) mode and the internal standard method was utilized for quantification.

Accuracy of Tooth Segmentation in the Digital Kesling Setup of Two Different Software Programs: A Retrospective Study.

Introduction Precise virtual setup creation and orthodontic appliance fabrication depend on accurate teeth segmentation from intraoral scans. This accuracy is also fundamental for successful orthodontic treatment, as it ensures correct diagnosis and optimal treatment planning. A number of software packages that facilitate the building of virtual setups have been made available in recent years.

Exploring the potential mechanisms of Mahuang Fuzi Xixin decoction in treating elderly bronchial asthma through network pharmacology, molecular docking, and molecular dynamics simulations.

Modern medical practice has confirmed the efficacy of Mahuang Fuzi Xixin Decoction (MHFZXXD) in treating elderly bronchial asthma, but its specific mechanisms of action remain to be clarified. Therefore, this study utilizes network pharmacology, molecular docking techniques, and molecular dynamics simulations to explore the key active components, core target genes, and potential mechanisms of MHFZXXD in the treatment of elderly bronchial asthma. Active components and related targets of MHFZXXD were identified through the retrieval and screening of the TCMSP, Swiss Targets Prediction, and Uniprot databases.