Ocular inoculation of toad venom: toxic cataract and proteomic profiling.

Purpose: To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen.

Methods: A young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of toad venom inoculation. He was diagnosed with a toxic cataract, and underwent phacoemulsification cataract surgery.

Structural basis for human NKCC1 inhibition by loop diuretic drugs.

Na-K-Cl cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are first-line medicines for the treatment of edema and hypertension. NKCC1 activation by the molecular crowding sensing WNK kinases is critical if cells are to combat shrinkage during hypertonic stress; however, how phosphorylation accelerates NKCC1 ion transport remains unclear.

Numerical analysis of sodium diffusion in aluminum electrolysis cathode carbon blocks based on a microstructure multi-factor corrected model.

Current researches on sodium penetration in electrolytic aluminum cathode carbon blocks primarily measure cathode expansion curves, showing mostly macroscopic characteristics. However, the microscopic structure is often underexplored. As a porous medium, the diffusion performance of cathode carbon blocks is closely tied to their internal pore structure.

Identification of drivers of global trade in plastic waste based on GCA and ISM-MICMAC model: Taking China, USA and South Africa as cases.

Plastic waste's dual characteristics of "resource" and "pollution" led to the prevalence of trade. The Global Plastic Waste Trade Network (GPWTN) is heterogeneous, and its structure is susceptible to the influence of key countries within it. However, there is a shortage of research on the key countries and trade drivers influencing GPWTN evolution.

Evolutionary dynamics of SARS-CoV-2 variants under strict non-pharmaceutical interventions - a population-based study.

Introduction: China implemented a dynamic zero-COVID strategy to curb viral transmission in response to the coronavirus disease 2019 (COVID-19) pandemic. This strategy was designed to inhibit mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19. This study explores the dynamics of viral evolution under stringent non-pharmaceutical interventions (NPIs) through real-world observations.

SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.

Zinc homeostasis plays an essential role in maintaining immune function and is tightly regulated by zinc transporters. We previously reported that the zinc transporter SLC39A10, located in the cell membrane, critically regulates the susceptibility of macrophages to inflammatory stimuli; however, the functional role of SLC39A10 in T cells is currently unknown. Here, we identified two SNPs in SLC39A10 that are associated with inflammatory bowel disease (IBD).

Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China.

Mpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European and American countries and subsequently spread to over 100 countries and regions worldwide. The rapid evolution of MPXV, coupled with increased international interactions, has led to a gradual rise in mpox cases in certain regions of Asia, mostly involving MPXV clade II and its branch strains.

Modeling and Simulation of Dynamic Recrystallization Microstructure Evolution for GCr15 Steel Using the Level Set Method.

The microstructure of metallic materials plays a crucial role in determining their performance. In order to accurately predict the dynamic recrystallization (DRX) behavior and microstructural evolution during the hot deformation process of GCr15 bearing steel, a microstructural evolution model for the DRX process of GCr15 steel was established by combining the level set (LS) method with the Yoshie-Laasraoui-Jonas dislocation dynamics model. Firstly, hot compression tests were conducted on GCr15 steel using the Gleeble-1500D thermal simulator, and the hardening coefficient and dynamic recovery coefficient of the Yoshie-Laasraoui-Jonas model were derived from the experimental flow stress data.

High Antennal Expression of and Participate in the Recognition of Alarm Pheromones by Buren.

Insects have highly developed olfactory systems in which cytochrome P450s (CYPs) were involved as odor-degrading enzymes throughout the olfactory recognition of odor compounds by insects to avoid continuous stimulation of signaling molecules and thus damage to the olfactory nervous. To understand whether the highly expressed CYPs in the antennae play an olfactory function in worker, in this study, we find six highly expressed antennal CYPs from the transcriptome of . Multiple sequence alignment and phylogenetic analysis divided them into two families: the CYP3 family (, ) and the CYP4 family (, , , ).

Current Status, Challenges, and Perspectives in the Conservation of Native Honeybees and Beekeeping in Cambodia.

The four honeybee species native to Cambodia-, , , -play a vital role in ecosystem health and agricultural productivity through their pollination activities. Beekeeping in Cambodia has primarily developed around the introduced species . However, it remains underdeveloped compared to neighboring countries, with wild honey collection continuing to play a significant role.

Effect of Gene Polymorphisms on Fatty Acid Composition, Chemical Composition, and Carcass Traits in Sonid Sheep.

Fatty acids (FAs) are a group of organic compounds that are regulated by polygenic and environmental factors and affect the taste, nutritional value, and quality of meat. Lamb meat is rich in FAs required by the human body, which has directed more attention to sheep research and meat production. The fatty acid-binding protein 4 () gene is considered a candidate gene that can affect FA composition in livestock.

What are the problems and suggestions related to cancer health education in Sichuan, China? A qualitative study of community health workers (CHWs).

Background: Health education conducted by community health workers (CHWs) is an evidence-based strategy for promoting cancer prevention, cancer screening, and adherence to medical guidance from doctors. However, CHWs are confronted with some problems related to cancer health education in China. This study aimed to clarify CHWs' awareness of problems in cancer health education in China and the solutions that they were considering to improve the quality and efficiency of cancer health education.

[Hydrodynamic finite element analysis of biological scaffolds with different pore sizes for cell growth and osteogenic differentiation].

Objective: The triply periodic minimal surface (TPMS) Gyroid porous scaffolds were built with identical porosity while varying pore sizes were used by fluid mechanics finite element analysis (FEA) to simulate the microenvironment. The effects of scaffolds with different pore sizes on cell adhesion, proliferation, and osteogenic differentiation were evaluated through calculating fluid velocity, wall shear stress, and permeability in the scaffolds.

Methods: Three types of gyroid porous scaffolds, with pore sizes of 400, 600 and 800 μm, were established by nTopology software.

[Regulatory roles of and genes in plant oil synthesis].

There is a large gap between production and demand of plant oil in China, which leads to the heavy reliance on imports. Diacylglycerol acyltransferase (DGAT) and phospholipid: diacylglycerol acyltransferase (PDAT) are two key enzymes responsible for the synthesis of triacylglycerol, thereby affecting the yield and quality of plant oil. This paper comprehensively reviews the research progress in and in terms of their biological functions in plant oil synthesis, the molecular mechanisms of regulating plant lipid metabolism, growth, and development under stress, and their roles in driving oil synthesis under the background of synthetic biology.

The status of China's international division of labour from Marx's theory of international value.

Based on Marx's theory of international value, this paper analyzes the carrier of unequal exchange and the path of international transfer of surplus value, constructs an international division of labour status index by comprehensively observing the organic composition of capital in the export and import sectors, and tries to accurately grasp the characteristics of the current international division of labour pattern coexisting between horizontal products and vertical products. At the same time, based on the data of all available HS92 six-digit code categories in various countries in the world from 1993 to 2016, the level of international division of labour in China is empirically analysed. The results show that: (1) there is no breakthrough in the situation of China's low status of international division of labour; (2) the high capital-organic composition of the import sector is the main reason for the low status of international division of labour; (3) the continuous decline in the absolute value of captured surplus is a global phenomenon; (4) WTO accession has not significantly improved the status of international division of labour.

[Preliminary application of human-computer interaction CT imaging AI recognition and positioning technology in the treatment of type C1 distal radius fractures].

Objective: To explore the accuracy of human-computer interaction software in identifying and locating type C1 distal radius fractures.

Methods: Based on relevant inclusion and exclusion criteria, 14 cases of type C1 distal radius fractures between September 2023 and March 2024 were retrospectively analyzed, comprising 3 males and 11 females(aged from 27 to 82 years). The data were assigned randomized identifiers.

[Relationship between knee meniscus and posterior tibial slope in healthy adults and patients with anteromedial osteoarthritis in Heilongjiang province].

Objective: To measure and analyze the relationships among the posterior tibial slope (PTS), meniscal slope (MS), and meniscus posterior horn thickness (MPHT) of the medial and lateral tibial plateau in healthy people and patients with anteromedial osteoarthritis (AMOA) in Heilongjiang province, so as to provide reference basis for appropriate tibial osteotomy and prosthesis placement angles in knee joint surgeries.

Methods: A retrospective collection of imaging data from knee joint MRI examinations conducted prior to AMOA for various reasons was performed. A total of 103 healthy individuals (healthy group) and 30 AMOA patients (AMOA group) were included.

Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta.

Perfluorononanoic acid (PFNA), widely employed in surfactants, coatings, plastics, corrosion inhibitors, and fire-extinguishing agents, is less regulated than PFOS or PFOA but displays higher bioaccumulation and potential toxicity. Most toxicity assessments have focused on mammals, fish, and algae, with limited research on ground-dwelling arthropods, especially ants. Here, we examined PFNA's toxic effects on red imported fire ants (RIFAs), a prevalent ground-dwelling species in South China.

A retrospective study of the effects of different surgical procedures on the mandibular nerve canal involved by odontogenic keratocyst.

Objectives: This study aims to evaluate the changes in the mandibular canal following the treatment of large odontogenic keratocysts through decompression and curettage, providing a theoretical basis for sequential treatment.

Methods: Twenty patients were selected for each decompression and curettage treatment of large odontogenic keratocysts in the mandible. Postoperative follow-up with was conducted every three months, during which cone beam computed tomography (CBCT) scans were performed.

Comprehensive analysis of adverse events associated with onasemnogene abeparvovec (Zolgensma) in spinal muscular atrophy patients: insights from FAERS database.

Onasemnogene Abeparvovec (Zolgensma) is a gene therapy for the treatment of Spinal Muscular Atrophy (SMA) with improved motor neuron function and the potential for a singular treatment. Information on its adverse drug reactions is mainly from clinical trials and real-world studies with extensive sample sizes are lacking. In this study, we analyzed the U.

[Plasma exchange combined with continuous renal replacement therapy for imported severe malaria: a case report].

The article presents the diagnosis and treatment of an imported case with severe malaria, and the effect of plasma exchange combined with continuous renal replacement therapy. Severe malaria is characterized by complex clinical symptoms and multiple complications, and plasma exchange combined with continuous renal replacement therapy has a satisfactory therapeutic efficacy for severe malaria.

Epidemiological and cluster characteristics of dengue fever in Yunnan Province, Southwestern China, 2013-2023.

Background: Yunnan Province, located in the southwestern part of China and neighboring endemic dengue regions of Southeast Asia, has experienced annual autochthonous outbreaks of dengue fever from 2013 to 2023. This study examines the epidemiological and spatiotemporal clustering characteristics of dengue within the province.

Methods: Descriptive epidemiological methods were used to analyse outbreak characteristics.

Predicting dengue incidence in high-risk areas of China through the integration of Southeast Asian and local meteorological factors.

Dengue, a climate-sensitive mosquito-borne viral disease, is endemic in many tropical and subtropical areas, with Southeast Asia bearing the highest burden. In China, dengue epidemics are primarily influenced by imported cases from Southeast Asia. By integrating monthly maximum temperature and precipitation from Southeast Asia and local provinces in China, we aim to build models to predict dengue incidence in high-risk areas of China.

Comparative study regarding the stability of a proximal ulnar stump with or without distal oblique bundle reconstruction during the Sauvé‒Kapandji procedure: a finite-element analysis.

Background: The most common postoperative complication of the Sauvé‒Kapandji (S-K) procedure is proximal ulnar stump instability. The distal oblique bundle (DOB) is a stable tissue used to stabilize the distal radioulnar joint. This study created finite-element models of the distal oblique bundle (DOB) to determine its effect on the proximal ulnar stump instability encountered during the Sauvé‒Kapandji procedure.