950 results match your criteria: "China Guangxi Institute of Traditional Chinese Medicine & Pharmaceutical Science Nanning China.[Affiliation]"

Transferrin-modified carboxymethyl chitosan-chitosan nanoparticles as an efficient delivery carrier for targeted therapy of depression.

Int J Biol Macromol

January 2025

School of Chemistry and Chemical Engineering, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China. Electronic address:

Limitations of the blood-brain barrier (BBB) are responsible for the low efficacy and high toxicity of many antidepressants. However, strategies to enhance BBB targeting to improve the efficacy and safety of antidepressants remain challenging. In this study, we prepared transferrin (Tf)-functionalized chitosan (CS)-N,O-carboxymethy chitosan (NOCMS) nanosystems (NPs) (NOCMS-CS-Tf NPs), which can enhance BBB targeting in the depressive environment and allow more NPs to enter the brain.

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LAT1 transporter as a target for breast cancer diagnosis and therapy.

Eur J Med Chem

February 2025

Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, 530200, China; Guang Xi Zhuang Yao Medicine Center of Engineering and Technology, Wuhe Rode, Nanning, 530200, China. Electronic address:

Article Synopsis
  • - Breast cancer is the leading cause of cancer-related deaths among women in China, highlighting the urgent need for new biomarkers for diagnosis and treatment as current cellular molecules are ineffective.
  • - LAT1 (SLC7A5) is significantly involved in the uptake of amino acids in breast cancer cells and is linked to several cancer behaviors like growth and drug resistance, varying in expression among different breast cancer types.
  • - The article reviews LAT1's structure, function, and its emerging role as a potential diagnostic and therapeutic target, especially given advancements in small molecular inhibitors and nanotechnology aimed at treating breast cancer.
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Juvenile toxicity of atropine sulfate eye drops in young rats.

Cutan Ocul Toxicol

December 2024

Guangdong Provincial Center for Ophthalmic Drug Creation and Evaluation Engineering Technology, Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong, China.

Objectives: This study was to investigate the effects of atropine sulphate eye drops (ASED)on the development of partial systems in young rats and their toxic reactions following repeated eye-drop administration over a period of 40 days.

Methods: SD rats of 20 days old were randomly assigned to control group, 0.01, 0.

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Article Synopsis
  • Lumbar disc herniation (LDH) is a prevalent source of lower back pain and sciatica, with posterior lumbar interbody fusion (PLIF) being a standard treatment method, prompting a study on predicting blood transfusion needs during surgery.
  • This study involved 6,241 patients across 22 medical centers in China and utilized various machine learning techniques to create an optimal predictive model for intraoperative blood transfusion using robust evaluation methods.
  • The best-performing model, a simulated annealing support vector machine recursive + stacking model, achieved an area under the curve of 0.884, leading to the creation of a publicly accessible web calculator to aid clinicians in decision-making and improve patient management.
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The genus is renowned for its remarkably diverse floral morphology, exhibiting a high level of disparity compared to most genera within Gesneriaceae. In this study, we present a detailed description and illustration of T. Ding & B.

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Background: Lour., a genus in the subfamily Cercidoideae of the family Leguminosae, is characterized by woody liana habit, tendrils, and distinctive bilobate or bifoliolate leaves. The genus holds important medicinal value and constitutes a complex group characterized by morphological diversity and unstable taxonomic boundaries.

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Background: Alcohol is linked to various cancers. While many studies have focused on developed countries, the burden of alcohol-related cancers in developing countries remains underexplored.

Methods: We analyzed data from the Global Burden of Disease Study (2000-2019) to assess mortality and disability-adjusted life years (DALYs) from alcohol-related cancers in low and low-to-middle sociodemographic index (SDI) countries.

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Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors.

Glob Med Genet

December 2024

Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.

Article Synopsis
  • FGFR is a vital receptor involved in growth and tissue repair, but its gene mutations can lead to cancer by disrupting essential processes.
  • Small molecule drugs and antibodies targeting FGFR mutations, like erdafitinib and pemigatinib, have shown clinical efficacy in treating certain cancer types.
  • Effective screening methods for FGFR variants are essential for utilizing FGFR inhibitors in treatment, and a consensus has been developed to standardize diagnosis and treatment processes.
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Background: YOXINTINE contains >98 % of 20(S)-protopanaxadial (PPD), a metabolic product of ginsenosides with pre-clinical neuroprotective activity. Animal experiments and previous studies have shown that PPD has good antidepressant effect and safety.

Purpose: To evaluate YOXINTINE in treating depression compared with a placebo in Chinese patients.

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Background: Electrolyte imbalances are commonly observed in individuals diagnosed with myocardial infarction (MI). The levels of serum sodium have been linked to unfavorable outcomes in relation to MI. Additionally, there exists a correlation between serum sodium and serum chloride, although the combined influence of these electrolytes on the prognosis of MI patients has not been extensively studied.

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Article Synopsis
  • - The guideline aims to assist in choosing biomarkers for diagnosing and evaluating patients with axial spondyloarthritis (axSpA) through a collaboration of experts and evidence-based strategies.
  • - A total of 20 recommendations were made, including strong suggestions for HLA-B27 testing and regular monitoring of CRP/ESR, while others focused on potential biomarkers for various clinical purposes.
  • - The guideline emphasizes that healthcare professionals should consider costs, accessibility, and patient preferences when selecting tests, and it provides a toolkit of endorsed biomarkers for better clinical decision-making.
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Background: The application of traditional Chinese medicine (TCM) therapy to acute leukemia has been intensively investigated. However, the bibliometric analysis in this field has not been performed. This bibliometric study aimed to comprehensively analyze the research trends and active areas of TCM therapy for acute leukemia from 2000 to 2023.

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Expert consensus on the diagnosis and treatment of solid tumors with BRAF mutations.

Innovation (Camb)

November 2024

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital & Institute, Beijing 100142, P.R. China.

Article Synopsis
  • * BRAF mutations are common in various cancers, and targeted therapies, especially BRAF inhibitors like dabrafenib and trametinib, are developed for treating solid tumors with these mutations.
  • * An expert consensus has been established to improve the diagnosis and treatment of solid tumors with BRAF mutations, focusing on summarizing their clinical features, recommending genetic testing methods, and creating a systematic approach for patient care.
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A deep learning-based method for assessing tricuspid regurgitation using continuous wave Doppler spectra.

Sci Rep

November 2024

Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cardiovascular Disease, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Transthoracic echocardiography (TTE) is widely recognized as one of the principal modalities for diagnosing tricuspid regurgitation (TR). The diagnostic procedures associated with conventional methods are intricate and labor-intensive, with human errors leading to measurement variability, with outcomes critically dependent on the operators' diagnostic expertise. In this study, we present an innovative assessment methodology for evaluating TR severity utilizing an end-to-end deep learning system.

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The Metabolic Characteristics and Bioavailability of Resveratrol Based on Metabolic Enzymes.

Nutr Rev

November 2024

Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, Jiangsu Province 225009, China.

The natural polyphenol resveratrol (RV) has garnered fame for its extensive pharmacological properties. Although clinical studies have shown some positive results, many contradictory outcomes remain. An important obstacle to the development of therapeutic applications for RV is its low bioavailability in vivo.

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Phylotranscriptomics reveals the phylogeny of Asparagales and the evolution of allium flavor biosynthesis.

Nat Commun

November 2024

Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 211198, Nanjing, China.

Asparagales, the largest monocot order, is renowned for its ecological, economic, and medicinal significance. Here, we leverage transcriptome data from 455 Asparagales species to explore the phylogeny of Asparagales. Moreover, we investigate the evolutionary patterns of the genes involved in allium flavor formation.

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Cerebral biomimetic nano-drug delivery systems: A frontier strategy for immunotherapy.

J Control Release

December 2024

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address:

Brain diseases are a significant threat to human health, especially in the elderly, and this problem is growing as the aging population increases. Efficient brain-targeted drug delivery has been the greatest challenge in treating brain disorders due to the unique immune environment of the brain, including the blood-brain barrier (BBB). Recently, cerebral biomimetic nano-drug delivery systems (CBNDSs) have provided a promising strategy for brain targeting by mimicking natural biological materials.

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Objective: To investigate the current status of elderly health services in medical institutions at all levels within Guangxi Province, China.

Methods: Using a purposeful sampling method, a questionnaire survey was conducted from July 24, 2023 to October 24, 2023 on the general situation, human resources, rehabilitation medicine, nursing services, and the development of hospice care at 1305 medical institutions in Guangxi.

Results: Among the surveyed 1305 medical institutions in Guangxi, 172 (13.

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Wireless matrix metalloproteinase-9 sensing by smart wound dressing with controlled antibacterial nanoparticles release toward chronic wound management.

Biosens Bioelectron

January 2025

Taizhou Key Laboratory of Medical Devices and Advanced Materials, Research Institute of Zhejiang University, Taizhou, 318000, PR China; Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, PR China. Electronic address:

Chronic wounds cause serious health and economic burdens on patients and society. Herein, a wireless and flexible smart wound dressing was developed for matrix metalloproteinase-9 (MMP-9) monitoring and antimicrobial treatment toward chronic wound management. The highly sensitive radio frequency MMP-9 sensor was realized based on a bioresponsive hydrogel with the bioactive peptide sequences.

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CT imaging analysis of the C7 pedicle and lateral mass in children aged 0-14 years.

Ann Anat

January 2025

Key Laboratory of Molecular Pathology in Tumors of GuangxiHigher Education Institutions, Baise, Guangxi 533000, PR China; Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, PR China. Electronic address:

Article Synopsis
  • - The study investigates the anatomy of the C7 pedicle and lateral mass in children aged 0-14, focusing on growth patterns to improve pediatric lower cervical spine surgeries and design of C7 screws.
  • - Researchers measured 12 parameters, analyzing size and angle data, finding that most parameters increased with age while some angles fluctuated; gender differences were noted primarily in length measurements.
  • - The findings offer detailed CT imaging anatomy for the C7 region, emphasizing the importance of preoperative CT scans and precise measurements for future pediatric surgeries.
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Structurally diverse triterpenoids with antibacterial activities from Euphorbia humifusa.

Bioorg Chem

December 2024

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address:

An exploration of antibacterial components from the whole plant of Euphorbia humifusa led to the isolation of 14 new triterpenoids, euphohumifusoids A-N (1-7 and 9-15), as well as four known analogues (8 and 16-18). Their structures were elucidated by extensively analysis of the spectroscopic data and X-ray crystallography using Cu Kα radiation. Among them, euphohumifusoid A (1) bears an unique 6(7 → 8)abeo scaffold originated from a D:C-friedo-oleanane skeleton for the first time, euphohumifusoids H and I (9 and 10) possess a rare α,β-unsaturated-γ-lactone chain originated from 25,26,27-trinordammaranes, and euphohumifusoid L (13) is a highly modified 3,4-seco-25,26,27-trinorcycloartane.

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Laoxianghuang polysaccharide promotes the anti-inflammatory cytokine interleukin-10 in colitis via gut microbial linoleic acid.

Phytomedicine

December 2024

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China. Electronic address:

Background: Our previous study found that the polysaccharide from Laoxianghuang (LP), fermented fruit of bergamot (traditional Chinese medicine and food), can alter gut microbiota and regulate short-chain fatty acids (SCFAs) in vitro. Nevertheless, there is a paucity of reports on the impact of LP on gut microbiota in vivo.

Purpose: To analyze the structures of LP, investigate the influence of LP on the damaged intestinal barrier in DSS-induced colitis mice, and further explore its potential mechanisms.

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Inhibiting lncRNA NEAT1 Increases Glioblastoma Response to TMZ by Reducing Connexin 43 Expression.

Cancer Rep (Hoboken)

October 2024

Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Research Center of Traditional Chinese Medicine and Ethnic Medicine, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning, China.

Objectives: Glioblastoma multiforme (GBM) is considered the most assailant subtype of gliomas, presenting a formidable obstacle because of its inherent resistance to temozolomide (TMZ). This study aimed to characterize the function of lncRNA NEAT1 in facilitating the advancement of gliomas.

Methods: The expression level of NEAT1 in glioma tissues and cells was detected by qRT-PCR.

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 (Rubiaceae), a new species from Guangxi, China.

PhytoKeys

October 2024

College of Forestry, Central South University of Forestry and Technology, Changsha, Hunan, China Central South University of Forestry and Technology Changsha China.

Y.Nong & L.Wu (Rubiaceae), a new species from Guangxi, China, is described and illustrated.

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