27 results match your criteria: "China Astronaut Research and Training Centre[Affiliation]"
Inhibition of autophagy recovers cardiac dysfunction and atrophy in response to tail-suspension.
Life Sci
January 2015
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Centre, 26# Beiqing Road, Beijing 100094, PR China. Electronic address:
Aims: Physical inactivity during space flight or prolonged bed rest may cause cardiac dysfunction and atrophy, but the exact mechanism that governs the regulation of myocardial dysfunction and cardiac atrophy remains poorly understood. Autophagy, a protein degradation pathway, has recently been shown to be involved in the regulation of cardiac dysfunction and atrophy. In this study, we investigated the relationships between dysfunction and inactivity-induced atrophy and autophagy in rat cardiac tissue.
View Article and Find Full Text PDF[Stimulating Toll-like receptor 2 promotes the cell apoptosis through augmenting the expression of NIPK in lung epithelial cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
August 2014
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Centre, Beijing 100094, China.
Objective: To investigate if stimulating Toll-like receptor 2 (TLR2) specifically induces the cell apoptosis in mouse lung epithelial cells (MLE-12) and related potential mechanism.
Methods: TLR2 was stimulated by 0, 1, 3.3, 10, 33 ng/mL PAM3CYS4 for 24 hours, or 33 ng/mL PAM3CYS4 for 0, 8, 16, 24, 36, 48 hours, respectively.