2 results match your criteria: "China Anhui Provincial Engineering Technology Research Center of Biopreservation and Artificial Organs[Affiliation]"
Association of genetic variants in SOHLH1 and SOHLH2 with non-obstructive azoospermia risk in the Chinese population.
Eur J Obstet Gynecol Reprod Biol
January 2015
Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Institute of Reproductive Medicine, Anhui Medical University, Hefei, China; Anhui Provincial Engineering Technology Research Center of Biopreservation and Artificial Organs, Hefei, China. Electronic address:
Objective: Spermatogenesis and oogenesis specific basic helix-loop-helix 1 (SOHLH1) and spermatogenesis and oogenesis specific basic helix-loop-helix 2 (SOHLH2) play essential roles for both spermatogenesis and oogenesis. The aim of this study was to evaluate the association of SOHLH1 and SOHLH2 single nucleotide polymorphisms (SNPs) with non-obstructive azoospermia (NOA) in the Chinese population.
Study Design: In this study, we assessed 7 single nucleotide polymorphisms (SNPs) of SOHLH1 and SOHLH2 with Sequenom iplex technology in 361 NOA cases and 368 fertile controls.
CREM variants rs4934540 and rs2295415 conferred susceptibility to nonobstructive azoospermia risk in the Chinese population.
Biol Reprod
August 2014
Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei, China Institute of Reproductive Medicine, Anhui Medical University, Hefei, China Anhui Provincial Engineering Technology Research Center of Biopreservation and Artificial Organs, Hefei, China.
To evaluate the association of variants related to spermatogenesis with susceptibility to Chinese idiopathic nonobstructive azoospermia (NOA), seventeen tag single-nucleotide polymorphisms (SNPs) in CREM, ACT, KIF17b, and SPAG8 were analyzed in 361 NOA patients and 368 controls by Sequenom iplex technology. The results showed that two CREM SNPs, rs4934540 and rs22954152, were significantly associated with NOA and played protective roles against the disease (P value with Bonferroni correction = 0.00017, odds ratio [OR] = 0.
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