CeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water.

The overuse of antibiotics has led to the severe contamination of water bodies, posing a considerable hazard to human health. Therefore, the development of an accurate and rapid point-of-care testing (POCT) platform for the quantitative detection of antibiotics is necessary. In this study, Cerium oxide (CeO) and Ferrosoferric oxide (FeO) nanoparticles were simultaneously encapsulated into N-doped nanofibrous carbon microspheres to form of a novel nanozyme (CeFe-NCMzyme) with a porous structure, high surface area, and N-doped carbon material properties, leading to a considerable enhancement of the peroxidase (POD)-like activity compared with that of the CeO or FeO nanoparticles alone.

Epigenetic regulation of targeted ferroptosis: A new strategy for drug development.

Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation. Epigenetic regulation plays a crucial role in the development and progression of diseases, making it essential to understand these mechanisms in order to identify potential targets for drug development and clinical treatment. The intersection of ferroptosis and epigenetics has opened up new avenues for research in drug development, offering innovative strategies for combating diseases.

Software-aided efficient identification of the components of compound formulae and their metabolites in rats by UHPLC/IM-QTOF-MS and an in-house high-definition MS library: Sishen formula as a case.

Identifying the compound formulae-related xenobiotics in bio-samples is full of challenges. Conventional strategies always exhibit the insufficiencies in overall coverage, analytical efficiency, and degree of automation, and the results highly rely on the personal knowledge and experience. The goal of this work was to establish a software-aided approach, by integrating ultra-high performance liquid chromatography/ion-mobility quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS) and in-house high-definition MS library, to enhance the identification of prototypes and metabolites of the compound formulae , taking Sishen formula (SSF) as a template.

Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.

Tetrandrine (TET), a natural bisbenzyl isoquinoline alkaloid extracted from S. Moore, has diverse pharmacological effects. However, its effects on melanoma remain unclear.

Prediction of the potentially suitable areas of in China based on Maxent and Marxan models.

Pall. () is an important medicinal plant in China with high ornamental value. Predicting the potential habitat of is crucial for identifying its geographic distribution characteristics and ensuring its ecological and economic importance.

Effects of salt stress on plant and rhizosphere bacterial communities, interaction patterns, and functions.

Introduction: Salt stress significantly affects plant growth, and Na has gained attention for its potential to enhance plant adaptability to saline conditions. However, the interactions between Na, plants, and rhizosphere bacterial communities remain unclear, hindering a deeper understanding of how Na contributes to plant resilience under salt stress.

Methods: This study aimed to investigate the mechanisms through which Na promotes alfalfa's adaptation to salt stress by modifying rhizosphere bacterial communities.

LiDAR point cloud denoising for individual tree extraction based on the Noise4Denoise.

The processing of LiDAR point cloud data is of critical importance in the context of forest resource surveys, as well as representing a pivotal element in the realm of forest physiological and ecological studies.Nonetheless, conventional denoising algorithms frequently exhibit deficiencies with regard to adaptability and denoising efficacy, particularly when employed in relation to disparate datasets.To address these issues, this study introduces DEN4, an unsupervised, deep learning-based point cloud denoising algorithm designed to improve the accuracy of single tree segmentation in LiDAR point clouds.

Effect of operational parameters on droplet deposition characteristics using an unmanned aerial vehicle for banana canopy.

In recent years, as an important part of precision agricultural aviation, the plant protection unmanned aerial vehicle (UAV) has been widely studied and applied worldwide, especially in East Asia. Banana, as a typical large broad-leaved crop, has high requirements for pests and diseases control. The mechanization degree of plant protection management in banana orchard is low.

Advancing precision agriculture with deep learning enhanced SIS-YOLOv8 for Solanaceae crop monitoring.

Introduction: Potatoes and tomatoes are important Solanaceae crops that require effective disease monitoring for optimal agricultural production. Traditional disease monitoring methods rely on manual visual inspection, which is inefficient and prone to subjective bias. The application of deep learning in image recognition has led to object detection models such as YOLO (You Only Look Once), which have shown high efficiency in disease identification.

Iterative optimization annotation pipeline and ALSS-YOLO-Seg for efficient banana plantation segmentation in UAV imagery.

Precise segmentation of unmanned aerial vehicle (UAV)-captured images plays a vital role in tasks such as crop yield estimation and plant health assessment in banana plantations. By identifying and classifying planted areas, crop areas can be calculated, which is indispensable for accurate yield predictions. However, segmenting banana plantation scenes requires a substantial amount of annotated data, and manual labeling of these images is both timeconsuming and labor-intensive, limiting the development of large-scale datasets.

Application and development of CRISPR technology in the secondary metabolic pathway of the active ingredients of phytopharmaceuticals.

As an efficient gene editing tool, the CRISPR/Cas9 system has been widely employed to investigate and regulate the biosynthetic pathways of active ingredients in medicinal plants. CRISPR technology holds significant potential for enhancing both the yield and quality of active ingredients in medicinal plants. By precisely regulating the expression of key enzymes and transcription factors, CRISPR technology not only deepens our understanding of secondary metabolic pathways in medicinal plants but also opens new avenues for drug development and the modernization of traditional Chinese medicine.

Development of a vegetation canopy reflectance sensor and its diurnal applicability under clear sky conditions.

The spectral reflectance provides valuable information regarding vegetation growth and plays an important role in agriculture, forestry, and grassland management. In this study, a small, portable vegetation canopy reflectance (VCR) sensor that can operate throughout the day was developed. The sensor includes two optical bands at 710 nm and 870 nm, with the light separated by filters, and has a field of view of 28°.

Monitoring of agricultural progress in rice-wheat rotation area based on UAV RGB images.

Real-time monitoring of rice-wheat rotation areas is crucial for improving agricultural productivity and ensuring the overall yield of rice and wheat. However, the current monitoring methods mainly rely on manual recording and observation, leading to low monitoring efficiency. This study addresses the challenges of monitoring agricultural progress and the time-consuming and labor-intensive nature of the monitoring process.

Genome-wide analysis of sugar transporter gene family in and , expression profiling and identification of transcription factors.

Sugar, the primary product of photosynthesis, is a vital requirement for cell activities. Allocation of sugar from source to sink tissues is facilitated by sugar transporters (ST). These STs belong to the Major Facilitator Superfamily (MFS), the largest family of STs in plants.

Comparative response mechanisms of two cultivars of to f.sp. infection.

With the aim of enhancing plants' ability to respond to pathogenic fungi, this study focuses on disease resistance genes. We commenced a series of investigations by capitalizing on the pronounced differences in resistance to Fusarium wilt between resistant and susceptible varieties. Through an in-depth exploration of the metabolic pathways that bolster this defense, we identified genes associated with resistance to f.

Infantile epileptic spasms syndrome: an etiologic study of 361 patients with infantile epileptic spasms syndrome.

Introduction: Infantile Epileptic Spasms Syndrome (IESS) typically has a profound impact on the neurodevelopment of patients. The study on IESS indicates possible geographical variation in etiology and a lack of data from China. Our study intends to summarize the etiology of IESS and analyze its characteristics.

A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation.

Objective: To establish a prediction nomogram for early prediction of neonatal acute respiratory distress syndrome (NARDS).

Methods: This is a retrospective cross-sectional study conducted between January 2021 and December 2023. Clinical characteristics and laboratory results of cases with neonatal pneumonia were compared in terms of presence of NARDS diagnosis based on the Montreux Definition.

Bioceramic Surface Topography Regulating Immune Osteogenesis.

This study aims to clarify the effects of bioceramic interface cues on macrophages. Recently, there have been many researches exploring the effects of interface topography cues on macrophage polarization and cytokine secretion. However, the effects and underlying mechanisms of bioceramic interface cues on macrophages still need exploring.

Revolutionizing Tissue Clearing and 3-Dimensional Imaging: Transparent Embedding Solvent System for Uniform High-Resolution Imaging.

Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional (3D) imaging. A newly published transparent embedding system, TESOS (Transparent Embedding Solvent System), ensures consistent submicron resolution imaging throughout the entire sample, and can be compatible with different microscopy systems. This method shows great potential in connectome mapping, and might be an optimal option for future 3D multiplex immunofluorescence and RNA in situ hybridization imaging.

CT-based intratumoral and peritumoral radiomics nomogram to predict spread through air spaces in lung adenocarcinoma with diameter ≤ 3 cm: A multicenter study.

Purpose: The aim of this study was to explore and develop a preoperative and noninvasive model for predicting spread through air spaces (STAS) status in lung adenocarcinoma (LUAD) with diameter ≤ 3 cm.

Methods: This multicenter retrospective study included 640 LUAD patients. Center I included 525 patients (368 in the training cohort and 157 in the validation cohort); center II included 115 patients (the test cohort).

Prevalence and characterization of IncQ1α-mediated multi-drug resistance in Isolated from pigs in Kunming, Yunnan, China.

Background: is a conditionally pathogenic bacterium that is inherently resistant to polymyxin and tigecycline, largely due to antibiotic resistance genes (ARGs). These ARGs can be horizontally transferred to other bacteria, raising concerns about the Inc plasmid-mediated ARG transmission from , which poses a serious public health threat. This study aims to investigate the presence of Inc plasmid types in pig-derived in Kunming, Yunnan, China.

Long-term adoption of plow tillage and green manure improves soil physicochemical properties and optimizes microbial communities under a continuous peanut monoculture system.

Continuous monocropping of peanuts (.) often results in yield decline and soil degradation. The combination of green manure (GM) with tillage practices has been proposed as a sustainable strategy to maintain high crop productivity and improve soil quality.

Phylogeography and biological characterization of H12N2 virus isolated from whooper swan in Central China.

Wild birds and waterfowl serve as the natural reservoirs of avian influenza viruses (AIVs). When AIVs originating from wild birds cross species barriers to infect mammals or humans, they pose a significant threat to public health. The H12 subtype of AIVs primarily circulates in wild birds, with relatively few isolates reported worldwide, and the evolutionary and biological characteristics of H12 subtype AIVs remain largely unknown.

Electroacupuncture may protect pulmonary dysplasia in offspring with perinatal nicotine exposure by altering maternal gut microbiota and metabolites.

Background: Perinatal nicotine exposure (PNE) induces pulmonary dysplasia in offspring and it increases the risk of respiratory diseases both in offspring and across generations. The maternal gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), can regulate fetal lung development and are susceptible to nicotine exposure. Therefore, modulation of PNE-induced changes in maternal gut microbiota and SCFAs may prevent the occurrence of pulmonary dysplasia in offspring.

Screening and identification of two novel phosphate-solubilizing strains and their role in enhancing phosphorus uptake in rice.

Low phosphorus (P) use efficiency significantly impacts rice yields. An environmentally friendly approach to increase phosphorus absorption and utilization in rice involves the exploration of phosphorus-solubilizing fungal resources. This study aimed to isolate and characterize fungal strains from the rice rhizosphere and assess their phosphate solubilization capabilities, plant-growth-promoting (PGP) traits, and mechanisms involved.